Just, logically from what we know from infectious disease specialists, there 
often is a subset of individuals who react badly to inoculation. Does this 
invalidate the research and development that may have prevented millions of 
deaths? No, but there is no reason to oppose DeSantis or say, some other pol 
from wanting to identify if this is valid or not? Should a tiny fraction go 
about with masks and gloves, and never be inoculated? Or is this foolish from a 
public health perspective? IF big pharma has hidden adverse results, it is 
reasonable to know this. If athletes are keeling over left and right because of 
clots and carditis we oughta know? If this is just exaggeration, let's find 
out. 

-----Original Message-----
From: Stathis Papaioannou <stath...@gmail.com>
To: everything-list@googlegroups.com
Sent: Sat, Dec 17, 2022 10:19 pm
Subject: Re: Death, science, and politics



On Sun, 18 Dec 2022 at 13:09, Dylan Distasio <interz...@gmail.com> wrote:



On Sat, Dec 17, 2022 at 8:38 PM Brent Meeker <meekerbr...@gmail.com> wrote:

  
Why would you want the vaccine to stay in your left bicep?  Does someone 
suppose that a pertussis, or measles or polio vaccine just stayed in one 
tissue?  And the word "nanoparticle" is misleading.  I believe the mRNA 
molecules are in a fluid droplet; not some solid particle.

Why, because the way vaccines have worked pre-mRNA is that dendretic cells in 
the local injection area take up the antigen and present it to T-cells in the 
lymphatic system.   At that point the immune system is primed.   
The question of tissue distribution becomes much more important with mRNA 
vaccines because any cell that takes it up is going to produce the spike 
protein and be attacked by the immune system, meaning for example that if a 
large number of heart cells took it up and expressed spike protein, they are 
going to be attacked by the immune system as infected potentially leading to 
inflammation and other undesired side effects.

The coronavirus infects multiple tisssues in body, and almost every possible 
side-effect of vaccines, including rare ones such as myocarditis, are worse 
with the viral infection. This is what you would expect: viruses are parasites 
than invade the body and take over cells to make them produce more viruses, 
while vaccines are dead or attenuated viruses or a tiny part of the virus.

The makers of mRNA vaccines would certainly hope that the mRNA stays localized 
to the injection site; you will certainly not find them trumpeting the idea 
that it is a good thing for them to go all over the body.    You are risking 
inflammation and damage in any tissue they get into with a high level of 
distribution (more on possible mechanisms of action regarding myocarditis here 
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8607534/).
Nanoparticle is not misleading.   It is industry standard verbiage.   The mRNA 
is encapsulated in lipid nanoparticles which allows for protecting the naked 
mRNA and facilitating merging with the lipid cell 
membrane:https://www.nature.com/articles/s41578-021-00358-0 


   
 Why would tissue distribution be any different in a human than a rat or a dog? 
 Has that been shown to be case with other vaccines?


I'm not arguing it's different.   It's likely the same; that's the point.   
Widespread tissue distribution of spike protein mRNA is NOT a good thing, and 
completely unnecessary to facilitate a robust immune reaction.    Again, Pfizer 
and Moderna do not want to see this distribution.   In their ideal scenario, 
the only cells producing spike protein are in the localized injection site.-- 
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