On Sun, 18 Dec 2022 at 13:09, Dylan Distasio <[email protected]> wrote:
> > > On Sat, Dec 17, 2022 at 8:38 PM Brent Meeker <[email protected]> > wrote: > >> >> Why would you want the vaccine to stay in your left bicep? Does someone >> suppose that a pertussis, or measles or polio vaccine just stayed in one >> tissue? And the word "nanoparticle" is misleading. I believe the mRNA >> molecules are in a fluid droplet; not some solid particle. >> > > Why, because the way vaccines have worked pre-mRNA is that dendretic cells > in the local injection area take up the antigen and present it to T-cells > in the lymphatic system. At that point the immune system is primed. > > The question of tissue distribution becomes much more important with mRNA > vaccines because any cell that takes it up is going to produce the spike > protein and be attacked by the immune system, meaning for example that if a > large number of heart cells took it up and expressed spike protein, they > are going to be attacked by the immune system as infected potentially > leading to inflammation and other undesired side effects. > The coronavirus infects multiple tisssues in body, and almost every possible side-effect of vaccines, including rare ones such as myocarditis, are worse with the viral infection. This is what you would expect: viruses are parasites than invade the body and take over cells to make them produce more viruses, while vaccines are dead or attenuated viruses or a tiny part of the virus. The makers of mRNA vaccines would certainly hope that the mRNA stays > localized to the injection site; you will certainly not find them > trumpeting the idea that it is a good thing for them to go all over the > body. You are risking inflammation and damage in any tissue they get > into with a high level of distribution (more on possible mechanisms of > action regarding myocarditis here > https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8607534/). > > Nanoparticle is not misleading. It is industry standard verbiage. The > mRNA is encapsulated in lipid nanoparticles which allows for protecting the > naked mRNA and facilitating merging with the lipid cell membrane: > https://www.nature.com/articles/s41578-021-00358-0 > > >> >> Why would tissue distribution be any different in a human than a rat or a >> dog? Has that been shown to be case with other vaccines? >> > > I'm not arguing it's different. It's likely the same; that's the point. > Widespread tissue distribution of spike protein mRNA is NOT a good thing, > and completely unnecessary to facilitate a robust immune reaction. > Again, Pfizer and Moderna do not want to see this distribution. In their > ideal scenario, the only cells producing spike protein are in the localized > injection site. > > -- > You received this message because you are subscribed to the Google Groups > "Everything List" group. > To unsubscribe from this group and stop receiving emails from it, send an > email to [email protected]. > To view this discussion on the web visit > https://groups.google.com/d/msgid/everything-list/CAJrqPH-KPXSKRG902Rg8vokZ6rq_%3DR9_jCtWXC3OYb3FL%3DEdMw%40mail.gmail.com > <https://groups.google.com/d/msgid/everything-list/CAJrqPH-KPXSKRG902Rg8vokZ6rq_%3DR9_jCtWXC3OYb3FL%3DEdMw%40mail.gmail.com?utm_medium=email&utm_source=footer> > . > -- Stathis Papaioannou -- You received this message because you are subscribed to the Google Groups "Everything List" group. To unsubscribe from this group and stop receiving emails from it, send an email to [email protected]. To view this discussion on the web visit https://groups.google.com/d/msgid/everything-list/CAH%3D2ypU1W-NDjCECbT13wQwCBBmyMdPGxrkB_y9QXC9PXimdtw%40mail.gmail.com.
