On Sat, Dec 17, 2022 at 8:38 PM Brent Meeker <meekerbr...@gmail.com> wrote:
> > Why would you want the vaccine to stay in your left bicep? Does someone > suppose that a pertussis, or measles or polio vaccine just stayed in one > tissue? And the word "nanoparticle" is misleading. I believe the mRNA > molecules are in a fluid droplet; not some solid particle. > Why, because the way vaccines have worked pre-mRNA is that dendretic cells in the local injection area take up the antigen and present it to T-cells in the lymphatic system. At that point the immune system is primed. The question of tissue distribution becomes much more important with mRNA vaccines because any cell that takes it up is going to produce the spike protein and be attacked by the immune system, meaning for example that if a large number of heart cells took it up and expressed spike protein, they are going to be attacked by the immune system as infected potentially leading to inflammation and other undesired side effects. The makers of mRNA vaccines would certainly hope that the mRNA stays localized to the injection site; you will certainly not find them trumpeting the idea that it is a good thing for them to go all over the body. You are risking inflammation and damage in any tissue they get into with a high level of distribution (more on possible mechanisms of action regarding myocarditis here https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8607534/). Nanoparticle is not misleading. It is industry standard verbiage. The mRNA is encapsulated in lipid nanoparticles which allows for protecting the naked mRNA and facilitating merging with the lipid cell membrane: https://www.nature.com/articles/s41578-021-00358-0 > > Why would tissue distribution be any different in a human than a rat or a > dog? Has that been shown to be case with other vaccines? > I'm not arguing it's different. It's likely the same; that's the point. Widespread tissue distribution of spike protein mRNA is NOT a good thing, and completely unnecessary to facilitate a robust immune reaction. Again, Pfizer and Moderna do not want to see this distribution. In their ideal scenario, the only cells producing spike protein are in the localized injection site. -- You received this message because you are subscribed to the Google Groups "Everything List" group. To unsubscribe from this group and stop receiving emails from it, send an email to everything-list+unsubscr...@googlegroups.com. To view this discussion on the web visit https://groups.google.com/d/msgid/everything-list/CAJrqPH-KPXSKRG902Rg8vokZ6rq_%3DR9_jCtWXC3OYb3FL%3DEdMw%40mail.gmail.com.
