Hello all – I’m following Nori’s progress and please know, I’m keeping her in 
my thoughts and prayers too, hoping the Stanizolol/Doxy/Prednisolone combo 
works for her. She has chosen her owners well, thank you for taking such good 
care of her. And thanks Amani for the good advice as always.

Ardy

 

 

From: Felvtalk <felvtalk-boun...@felineleukemia.org> On Behalf Of Amani Oakley
Sent: Saturday, June 8, 2019 9:23 PM
To: felvtalk@felineleukemia.org
Subject: Re: [Felvtalk] Rescued kitten felv +

 

One option is to ask your vet to show you how to give her subcutaneous fluids, 
which I do all the time for my cats if needed. However, for now, it makes sense 
to leave her there I guess. I presume they are warming the IV fluids too, 
because again, with such a small kitten, it wouldn’t take much to chill her if 
the fluids are at room temperature or colder.

 

I guess it’s just me. I am pretty adamant about taking home my cats whenever 
possible, but I understand that Nori sounds like she needs some extra help. I 
just find that the cats respond far better to personal cuddling and love, and 
this makes them feel better, eat more, etc.

 

Hopefully, she will feel better tomorrow. 

 

I’m crossing my fingers for you and Nori. 

 

Amani

 

From: Felvtalk <felvtalk-boun...@felineleukemia.org 
<mailto:felvtalk-boun...@felineleukemia.org> > On Behalf Of Patricia Oliveira
Sent: June 8, 2019 9:53 PM
To: felvtalk@felineleukemia.org <mailto:felvtalk@felineleukemia.org> 
Subject: Re: [Felvtalk] Rescued kitten felv +

 

She has fluids IV all the time and replenishment of potassium. Receives 
external heating too. 

 

They monitor pressure (low sometimes), oxygenation, temperature and heart rate 
several times a day.

I wish she could come home soon but she has been dehydrated even with fluids 
IV. I don´t know if it is safe to bring her now.

 

 

 

Em sáb, 8 de jun de 2019 às 22:03, Amani Oakley <aoak...@oakleylegal.com 
<mailto:aoak...@oakleylegal.com> > escreveu:

Patricia

 

I agree with you that it is too early to tell, but for sure it is good news 
that the haematocrit is moving in the right direction. Very good news on the 
rosy gingiva.

 

Rouleaux is likely only due to the transfusion. She appears to have had a bit 
of transfusion reaction, so the cells may be sticking to one another as a 
result. (Red cells in Rouleaux formation means that the look like a stack of 
coins – one on top of the other. In humans, that presentation is consistent 
with multiple myeloma. I don’t think it means anything right now other than the 
new red cells may be reacting a bit with her own cells).

 

I think she is working through the transfusion reaction, so that is likely why 
she is sleeping because you said that immediately after the transfusion, she 
was active and eating on her own. 

 

Low platelets are consistent with the FeLV presentation and the impact on the 
bone marrow. Hopefully, the Stanozolol will help. I seem to recall that with my 
Zander, I had the red cell numbers recover first, before the platelets 
recovered.

 

I presume they have her on a heating pad to keep her body temperature up.

 

I suspect it might be premature to look at the neurology right now. She is 
working through a lot, and is a tiny kitten. She needs to be given time to 
recover from the transfusion reaction, and to allow the good food and 
medication to start to work. I don’t know how a neurological diagnosis could 
help you now, and one would expect the neurologist will have a difficult time 
seeing a true neurological deficit, with all the rest of the stuff happening.

 

I would also suggest that at some point, it is better for her to be with you at 
home. If they are not giving her anything like fluids, you might consider 
taking her home with you. I know with Zander, he reacted most strongly when I 
was there with him. I could get him to play a little bit and that made him feel 
better, and of course, lots of cuddles and kisses.

 

Amani

 

From: Felvtalk <felvtalk-boun...@felineleukemia.org 
<mailto:felvtalk-boun...@felineleukemia.org> > On Behalf Of Patricia Oliveira
Sent: June 8, 2019 8:52 PM
To: Sandra Wachtstetter <swacht1...@comcast.net <mailto:swacht1...@comcast.net> 
>; felvtalk@felineleukemia.org <mailto:felvtalk@felineleukemia.org> 
Subject: Re: [Felvtalk] Rescued kitten felv +

 

Thank you, Sandra  :)

 

I visited Nori today. The hospital is in another city so I can't go there every 
day. 

 

She is a rosy gingiva, but continues to sleep most of the time and with a low 
temperature. One of the veterinarians there thinks that temperature is lower 
because of malnutrition, she has almost no lean mass and no fat.

 

Nori will go through the evaluation of a neurologist tomorrow. Some hypotheses 
raised for this prostration are neurological, including a possible hypoxia 
before the first transfusion when her hematocrit was really low.

 

Her blood work today is 30% hematocrit, the higher till now! So i think red 
cells aren´t being destroyed anymore, is it right or is it early to know?  

 

Some red cells in Rouleaux. Leukocytes are still high (> 26.000), low platelets 
for the first time (92.000). 

 

Nori had an echocardiogram today too and it is ok.

 

Thank you!

 

Patrícia

 

Em sáb, 8 de jun de 2019 às 11:40, Sandra Wachtstetter <swacht1...@comcast.net 
<mailto:swacht1...@comcast.net> > escreveu:

Hello Patricia, you may already be doing this - but if not, please take a copy 
of Amani's conversations for the vet to read - may help.

Good luck - don't give up!!

Sandt W

 

On June 7, 2019 at 9:55 PM Patricia Oliveira <cinzaeamar...@gmail.com 
<mailto:cinzaeamar...@gmail.com> > wrote: 

Nori did not want to eat by herself so they are syringing food. They started 
another medication for nausea, although she does not vomit, they think that may 
be why she does not eat. 

 

Blood work showed changes in neutrophils (bizarre core?), veternary says it can 
be from leukemia.

 

The result of this transfusion was not as good as the other time :( 

 

i´ll talk to veterinary tomorrow morning again.

 

thank you!

 

Patrícia

 

 

 

Em sex, 7 de jun de 2019 às 16:13, Amani Oakley < aoak...@oakleylegal.com 
<mailto:aoak...@oakleylegal.com> > escreveu: 

Still sounds more like a transfusion reaction than anything with the meds.

 

Hang in there. See what the afternoon labs show. 

 

Amani

 

From: Felvtalk <felvtalk-boun...@felineleukemia.org 
<mailto:felvtalk-boun...@felineleukemia.org> > On Behalf Of Patricia Oliveira
Sent: June 7, 2019 1:44 PM
To: felvtalk@felineleukemia.org <mailto:felvtalk@felineleukemia.org> 
Subject: Re: [Felvtalk] Rescued kitten felv +

 

Hi, Amani

 

Nori is receiving doxy+prenisolone+stanazolol even in the hospital.

 

I know it can be a reaction but i thought higher dose of prednisolone would 
prevent hemolysis.

 

I also know it's normal for part of the red blood cells to be cleared right 
after the transfusion, but i don´t remember if it was icteric plasma on last 
one.

 

I was hopefull she would come back home tomorrow, now i don´t know if it will 
be possible.

 

Today she must have am echocardiogram too because x-ray showed an enlarged 
heart. 

 

Thank you!

 

 

 

Em sex, 7 de jun de 2019 às 14:18, Amani Oakley <aoak...@oakleylegal.com 
<mailto:aoak...@oakleylegal.com> > escreveu:

Hi Patricia

 

The Stanozolol often has a side-effect of elevating liver enzymes, though I 
cannot remember if it also increased bilirubin (which would be what would cause 
the icteric observation of the plasma). However, hang in there. If it is the 
Stanozolol, my experience is that the liver enzymes drop right back to normal, 
shortly after it is discontinued, and there is no lasting damage to the liver. 
For now, what you have described (low temp and slightly lower heart rate) seems 
more likely to be related to the transfusion itself, rather than anything else 
going on. 

 

It is also possible that with the additional transfusion, there is a higher 
than normal red cell destruction going on, which would be another explanation 
for the increased icterus in the blood (which will also show as an increase in 
bilirubin). Elevated bilirubin can often be caused by a reaction to a blood 
transfusion. If the high bilirubin is the indirect or the unconjugated portion, 
it is related to red cell break down. The direct bilirubin (conjugated portion) 
is related to liver function. The lab results are usually broken down to Total 
bilirubin and Direct bilirubin. The indirect portion is obtained by subtracting 
the direct amount from the total amount.

 

I myself went through the pressure of the vets wanting me to discontinue the 
Stanozolol because of abnormal liver enzymes. My logic was that there was 
nothing else. If I discontinued the Stanozolol, my cat would die, period. I 
continued and found that in the end, the liver enzymes normalized on their own, 
even though I had Zander on almost continuous Stanozolol for close to two years.

 

I know that you know that you are only temporarily helping Nori with blood 
transfusions, and the virus is still attacking cells, etc. In my opinion – and 
mine alone – my experience and research leads me to the conclusion that the 
combination of Doxycycline/Prednisone/Stanozolol worked to not only boost the 
red cell production, but I believe that the Doxycyline assisted in keeping the 
viruses from properly reproducing.

 

However, anticipate that when the vet gets back the second set of blood work, 
she may well try to tell you to discontinue the Stanozolol.

 

Amani 

 

 

 

From: Felvtalk <felvtalk-boun...@felineleukemia.org 
<mailto:felvtalk-boun...@felineleukemia.org> > On Behalf Of Patricia Oliveira
Sent: June 7, 2019 12:53 PM
To: felvtalk@felineleukemia.org <mailto:felvtalk@felineleukemia.org> 
Subject: Re: [Felvtalk] Rescued kitten felv +

 

Hi, Amani!

 

Nori got another transfusion last night, hematocrit was 11.9 before it. 

 

Today morning, i talk to the hospital's veterinarian, she said hematocrit went 
to 29 and Nori was fine, all normal parameters and eating by herself again. 

 

But plasma was intensely icteric. I think this means red cells being destroyed, 
isn't it?

 

About one hour ago, veterinarian said Nori was with low temperature and heart 
rate slightly lower than normal. She was waiting the new blood work. In the 
morning, it was done only hematocrit, not complete blood work.

 

i am worried again.

 

Thank you,

 

Patrícia

 

Em ter, 4 de jun de 2019 às 23:46, Amani Oakley <aoak...@oakleylegal.com 
<mailto:aoak...@oakleylegal.com> > escreveu:

I would be leery of the going the route suggested by the vet at this juncture. 
I seriously seriously doubt if the erythropoietin will help. See my earlier 
where I explain why.

 

Amani

 

From: Felvtalk <felvtalk-boun...@felineleukemia.org 
<mailto:felvtalk-boun...@felineleukemia.org> > On Behalf Of Patricia Oliveira
Sent: June 4, 2019 8:53 PM
To: felvtalk@felineleukemia.org <mailto:felvtalk@felineleukemia.org> 
Subject: Re: [Felvtalk] Rescued kitten felv +

 

Hi, Lorraine

 

Veterinary wants to increase prednisolone to immunosuppressive dose and add 
erythropoietin. She thinks it is immune-mediated anemia and not mycoplasma.

 

Nori is receiving  1,2 mg prednisolone, twice a day. She weighs only 1 kg. 

 

We did x-ray today too. No visible tumor but we found a possible cardiopathy 
("Increased globular-looking heart silhouette").

 

:(

 

 

 

Em ter, 4 de jun de 2019 às 20:50, Lorraine Johnston <johnston1...@comcast.net> 
escreveu:

Patricia,

 

I would go with the transfusion and also start erythropoietin.  Stanozolol is 
supposed to stimulate erythropoietin production, but she might need a boost of 
the ready-made drug just to keep her alive until then.

 

- Lorraine

 

"Sometimes it is the people no one can imagine anything of who do the things no 
one can imagine."  - Alan Turing 

 

From: Felvtalk [mailto:felvtalk-boun...@felineleukemia.org 
<mailto:felvtalk-boun...@felineleukemia.org> ] On Behalf Of Patricia Oliveira
Sent: Tuesday, June 4, 2019 6:34 PM
To: felvtalk@felineleukemia.org <mailto:felvtalk@felineleukemia.org> 
Subject: Re: [Felvtalk] Rescued kitten felv +

 

Hi,

 

We did another blood work today, her hematocrit is 13% now :(

 

She is very sleepy but responsive when i talk to her. 

 

I don´t know if i can wait some more days to see if stanozolol is working. Or 
maybe it would be better get another transfusion right now.

 

Today, vet talk about erythropoietin. Do you know if it can be used with 
stanozolol?

 

Thank you,

 

Patrícia

 

Em sáb, 1 de jun de 2019 às 14:44, Amani Oakley <aoak...@oakleylegal.com 
<mailto:aoak...@oakleylegal.com> > escreveu:

Hi Patricia – I gave all the pills together, morning and evening, except for 
the metoclopramide which was given ½ or so before meals. The rest I gave with 
the meals. I didn’t observe a problem with giving them together.

 

You might also try baby food to get Nori to eat. Get the pureed kind (beef or 
chicken with or without vegetables), so it can be sucked up into a syringe. If 
my Zander wasn’t eating (and he wasn’t at the start of the medication regime), 
then I would use a syringe to get the baby food into him. Baby food is easy to 
digest and has good things in it. I would target – say – five 3 cc 
syringe-fulls at each feeding. I would boost the number of syringe-fulls if 
possible. Eventually, Zander started eating the baby food on his own, and then 
I graduated to moist food, and really, anything he wanted until he put the 
weight back on.

 

I had a look at the picture you sent and Nori is adorable. I am crossing my 
fingers for you and for Nori. Keep us updated on her progress.

 

Amani

 

From: Felvtalk <felvtalk-boun...@felineleukemia.org 
<mailto:felvtalk-boun...@felineleukemia.org> > On Behalf Of Patricia Oliveira
Sent: June 1, 2019 12:36 PM
To: felvtalk@felineleukemia.org <mailto:felvtalk@felineleukemia.org> 
Subject: Re: [Felvtalk] Rescued kitten felv +

 

Hi, Amani!

 

Thanky you very much for you email!

 

Nori was discharged from the hospital yesterday night. She is eating baby dry 
food. I tried canned but she didn´t accept so weel. 

 

Today i bought other kinds of canned, i'll try them hoping she likes some one.

 

Compound pharmacy must delivery stanozolol today.

 

Are there any precautions regarding medication schedules? Close or far to doxy, 
for example?

 

This is Nori: https://catsnecropolis.blogspot.com/2019/06/nori-teve-alta.html 
<https://catsnecropolis.blogspot.com/2019/06/nori-teve-alta.html?fbclid=IwAR0cXMedtfi73B81pJI7QiYGwRTJf9VJp-JN7S_Tstb0ANeg0Hm4ObtFH_A>
 

 

 

Thank you!

 

Patrícia

 

Em qui, 30 de mai de 2019 às 20:52, Amani Oakley <aoak...@oakleylegal.com 
<mailto:aoak...@oakleylegal.com> > escreveu:

Sorry Patricia – after going on and on in my last email, I realized I hadn’t 
actually answered your question. I think you can probably use the stanozolol 
with the Doxycycline, without the prednisone, but prednisone itself has 
properties which help to boost red cell production. Try it out, keep close tabs 
on the haematology results and see if you are getting a good response on just 
Doxycycline and the Stanozolol. If not, add the prednisone. You may find that 
this combination assists with the FIP as well, as per my previous email.

 

Amani

 

From: Felvtalk <felvtalk-boun...@felineleukemia.org 
<mailto:felvtalk-boun...@felineleukemia.org> > On Behalf Of Patricia Oliveira
Sent: May 30, 2019 12:56 PM
To: felvtalk@felineleukemia.org <mailto:felvtalk@felineleukemia.org> 
Subject: [Felvtalk] Rescued kitten felv +

 

Hi from Brazil,

 

I rescued a very weak, dehydrated, extremely thin kitten.


She's hospitalized now. Her hematocrit was 8, had blood transfusion which 
raised hematocrit to 22, now it is 19. Low reticulocyte count.

She has difficulty walking, which we can not define if it is just weakness or 
neurological. Already had a seizure. 

She also have changes in her kidneys. It has been tested and is felv +

She is receiving doxy and the hospital vets would like to include prednisolone.

However, as it is not possible yet to rule out PIF, and the medication I could 
use in the case of PIF does not work if the cat received prednisolone, I am 
trying to avoid it.

The veterinarian agreed to prescribe stanozolol.

Can it be used without prednisolone, only with doxy she is already receiving?

Thank you!

 

Patrícia

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