[ccp4bb] 2-year postdoc fellowship (structural biology and biochemistry) available at Lund University

[Herwig Schüler]

We have a funded position available for a highly motivated postdoctoral 
researcher with an interest in X-ray crystallography, cryo-EM and enzymology.
https://portal.research.lu.se/en/persons/herwig-sch%C3%BCler
https://pubmed.ncbi.nlm.nih.gov/?term=Herwig+Sch%C3%BCler=date
https://maps.app.goo.gl/UhEtcE6joxNx5pg78
Please contact 
herwig.schu...@biochemistry.lu.se for 
more information.




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[ccp4bb] 2-year postdoctoral positio IBS Grenoble-France

[Carlos CONTRERAS-MARTEL]

Researcher in structural biology (w/m)

We have a funded 2-year postdoctoral position available in the 
Metalloproteins Unit at "Institut de biologie Structurale" (IBS) in 
Grenoble. The research will focus on the structural study of iron-sulfur 
(Fe-S) cluster biosynthesis in both prokaryotes and eukaryotes.


We are looking for a candidate with a Ph.D. in structural biology 
obtained less than 2 years ago, and proficiency in state-of-the-art 
cryoEM or X-ray crystallography software and techniques. More 
information about the position can be found here:


https://emploi.univ-grenoble-alpes.fr/job-offers/researcher-in-structural-biology-w-m--1396173.kjsp?RH=1681202200872

Don't hesite to contact us for more informations:
Mickaël Cherrier (mickael.cherr...@ibs.fr)
Yvain Nicolet (yvain.nico...@ibs.fr)


--
 Carlos CONTRERAS MARTEL, Ph.D.
 (CRHC CNRS)

 carlos.contreras-mar...@ibs.fr

 "Bacterial Pathogenesis Group"
Institut de Biologie Structurale
 UMR5075 CEA-CNRS-UGA

  IBS (PATBAC)
  Campus EPN
  71, avenue des Martyrs
  CS 10090
  38044 Grenoble CEDEX 9
  FRANCE


 tel : (+33) (0)4 57 42 86 41

http://www.ibs.fr/groupes/groupe-pathogenie-bacterienne/?lang=fr
http://www.ibs.fr/groups/bacterial-pathogenesis-group/?lang=en



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[ccp4bb] 2 fully funded PhD studentships in Newcastle University

[Paula Salgado]

Dear colleagues

Just wanted to highlight 2 fully funded PhD studentships in my lab with strong 
structural biology focus - protein crystallography, cryoEM, cryoET and 
combinatorial approaches, combined with biochemistry and microbiology to study 
antibiotic-resistant pathogen C. difficile.

Would really appreciate it if you can share with potential interested 
candidates in your institutions. I'm happy to chat and provide more details and 
support with applications.


  1.
MRC funded - Deadline 17 Dec, on C. difficile sporulation proteins; 
co-supervisor Dr Jamie Blaza, University of York

https://www.findaphd.com/phds/project/stopping-a-superbug-s-sleeping-cells-molecular-machines-of-sporulation-at-atomic-level/?p163517

  
2.  BBSRC funded - Deadline 15 Jan, on C. difficile S-layer; 
co-supervisor Dr Agnieska Bronowska (NU), Dr Karrera Djoko (Durham) and Prof 
Maria Harkiolaki (DLS)
https://www.findaphd.com/phds/project/bbsrc-nld-doctoral-training-partnership-piercing-the-armour-c-difficile-s-layer-permeability/?p165084

Many thanks!


===

Professor Paula S. Salgado
Chair of Structural Microbiology


Due to my own work/life balance, my reply might be delayed and you might get 
emails outside your normal working hours. In any case, I do not expect a 
response outside those hours. Stay safe.


Newcastle University Biosciences Institute
Faculty of Medical Sciences
2nd Floor Cookson Building
Newcastle University
Newcastle upon Tyne, NE2 4HH, UK

Tel: +44 (0)191 208 7432
Email: paula.salg...@ncl.ac.uk





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[ccp4bb] 2 Postdoctoral positions availibe in Huber group at CMD Oxford

[Lizbé Koekemoer]

The Huber lab at the Centre for Medicines Discovery (CMD) at the Nuffield
Department of Medicine, University of Oxford, is looking for two highly
motivated and enthusiastic postdoctoral researchers to work with us to
investigate the fundamental role of novel RNA and ubiquitin binding
proteins in human disease.

You will investigate the structural and functional properties of individual
proteins as well as associated complexes involved in RNA and ubiquitin
metabolism. In addition, first-in-class chemical ligands will be designed
in collaboration with academic and pharma partners and characterised in
relevant biochemical assays. There are opportunities to gain experience in
fragment-based drug discovery and join a team of interdisciplinary
researchers.

Applicants are expected to have a strong and demonstrable track record in
protein biochemistry and X-ray crystallography; experience with cryoEM is
highly desirable. Both positions are offered full time on a fixed term
contract for 2 years in the first instance.



Additional details about the posts can be found online:

   1. Job Details (corehr.com)
   

   – closing date: 09-Oct-2023 12:00
   2. Job Details (corehr.com)
   

   – closing date: 09-Oct-2023 12:00


Interested candidates are welcome to contact Kilian Huber before applying
in case there are any additional questions.



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[ccp4bb] 2 Postdoc and 1 Research assistant positions, Structural analysis of trypanosome kinetochores, University of Edinburgh, UK

[Bungo Akiyoshi]

We are seeking to appoint two outstanding individuals with PhD training in 
structural biology to reveal the structure and function of unconventional 
kinetochore proteins.
We are also looking for one research assistant who is eager to learn new 
techniques and help to run our group. This 4-year position comes with an 
optional opportunity to obtain a PhD.

For details, please refer to the following adverts.
- Postdoc positions: 
https://elxw.fa.em3.oraclecloud.com/hcmUI/CandidateExperience/en/sites/CX_1001/job/8367
 (application deadline: 25 September 2023)
- Research Assistant position: 
https://elxw.fa.em3.oraclecloud.com/hcmUI/CandidateExperience/en/sites/CX_1001/job/8448
 (deadline: 9 October 2023)

Our group aims to discover fundamental principles and requirements governing 
chromosome segregation machines in eukaryotes. Although it was widely believed 
that all eukaryotes would have a conserved set of kinetochore proteins, we 
identified more than 20 uncharacterized kinetochore proteins (named KKT1–25) in 
Trypanosoma brucei (causative agent of African sleeping sickness) and 
discovered that they constitute unconventional kinetochores specific to 
kinetoplastids, a group of evolutionarily-divergent eukaryotes (Akiyoshi and 
Gull, Cell 2014, Marcianò et al, Journal of Cell Biology 2021, Tromer et al., 
Open Biology 2021, Ludzia et al., Structure 2021). We are currently 
characterizing these KKT proteins using various techniques including cell 
biology, bioinformatics, super-resolution microscopy, biochemistry, biophysics, 
and structural biology (X-ray crystallography, NMR, electron tomography, and 
cryoEM/ET).

Please let me know if you have any query.

Best wishes,
Bungo

-
Bungo Akiyoshi, PhD
Wellcome Trust Senior Research Fellow
Wellcome Centre for Cell Biology
Institute of Cell Biology
School of Biological Sciences
The University of Edinburgh
Michael Swann Building
Max Born Crescent
Edinburgh EH9 3BF
https://www.ed.ac.uk/biology/wcb/research/research-group-leaders/bungo-akiyoshi
The University of Edinburgh is a charitable body, registered in Scotland, with 
registration number SC005336. Is e buidheann carthannais a th’ ann an Oilthigh 
Dhùn Èideann, clàraichte an Alba, àireamh clàraidh SC005336.



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[ccp4bb] 2-years postdoc position on electron crystallography in Vienna

[Tim Gruene]

Dear all,

the Centre for Chemical structure Analysis at the University of Vienna
is offering a 2-years postdoc position. The project is a joint project
with the Detector group at the Paul Scherrer Institut. A JUNGFRAU
detector will be combined with a JEOL Transmission Electron
Microscope for advanced data collection and aims at reaching a new level
of data quality in ED.

Applicants should apply via the job portal
https://jobs.univie.ac.at/job/University-Assistant-postdoctoral/975913901 
before end of September 2023. A detailed job description and
requirements are available there, too.

We aim at starting the project in autumn this year, but are flexible by
a few months.

We look forward to ambitious applicants for an exciting project.

Best regards,
Tim Gruene

P.S.: yes, this is the same position as posted August 7th, with the
updated link to the job portal of the University of Vienna

-- 
--
Tim Gruene
Head of the Centre for X-ray Structure Analysis
Faculty of Chemistry
University of Vienna

Phone: +43-1-4277-70202

GPG Key ID = A46BEE1A



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pgpCVM1UGBWBN.pgp
Description: OpenPGP digital signature

[ccp4bb] 2-years postdoc position on electron crystallography in Vienna

[Tim Gruene]

Dear all,

the Centre for Chemical structure Analysis at the University of Vienna
is offering a 2-years postdoc position. The project is a joint project
with the Detector group at the Paul Scherrer Institut. A JUNGFRAU
detector will be combined with a JEOL Transmission Electron
Microscope for advanced data collection and aims at reaching a new level
of data quality in ED.

The job advertisement will be available at jobs.univie.ac.at with
JOB ID 1030 early September this year. Attached is a job description.

We aim at starting the project in autumn this year.

We look forward to ambitious applicants for an exciting project.

Best regards,
Tim Gruene

sent to the Bruker mailing list and the CCP4BB
-- 
--
Tim Gruene
Head of the Centre for X-ray Structure Analysis
Faculty of Chemistry
University of Vienna

Phone: +43-1-4277-70202

GPG Key ID = A46BEE1A



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Job-Description_ED-Jungfrau.pdf
Description: Adobe PDF document


pgpSMLypJcP_p.pgp
Description: OpenPGP digital signature

[ccp4bb] 2-year postdoctoral position

[Omid Haji-Ghassemi]

Dear 3dEM list,

A position is available for a highly motivated and skilled Post-doctoral Fellow 
(PDF) at the University of Calgary in Calgary, Alberta, Canada. The successful 
candidate will lead X-ray and potentially cryo-EM experiments to understand 
receptor complex biology and drug targeting. The position will be held within 
the Departments of Biological Sciences under the co-supervision of Dr. Matt 
(Mathilakth) Vijayan and Dr. Omid Haji-Ghassemi. 
 
The successful applicant must have a Ph.D. in structural biology or related 
fields. Excellent theoretical knowledge and practical skills in either X-ray 
crystallography or other protein biophysical methods are required. This 
includes familiarity with the expression and purification of proteins.  The 
position forms part of a collaborative, multidisciplinary effort between the 
Vijayan and Haji-Ghassemi laboratories. As such, excellent oral and written 
English communication skills, the proven ability to work and as part of a team, 
and strong individual research productivity are essential.
 
Calgary is one of the sunniest and cleanest cities in North America. and has 
been named as one of the world’s most livable cities. Hence it is a great place 
to do research and build a career while living in an affordable city. Calgary 
is about an hour drive from the majestic Rocky Mountains and Banff.  

Qualified Applicants should submit a cover letter including contact information 
for three professional references, and a curriculum vitae including a list of 
publications. Application materials should be combined into a single PDF 
document and submitted via email to omid.hajighass...@calgary.ca. 

The position is available immediately. The appointment will be at the rank of 
Postdoctoral Fellow with an annual salary of 50,000, plus benefits for two 
years, with a possible 1-year extension. Candidates are encouraged to apply for 
post-doctoral fellowships including  Eyes High program from UCalgary. 

Equity and diversity are essential to academic excellence. An open and diverse 
community fosters the inclusion of voices that have been underrepresented or 
discouraged. We encourage applications from members of groups that have been 
marginalized on any the basis of sex, sexual orientation, gender identity or 
expression, racialization, disability, political belief, religion, marital or 
family status, age, and/or status as a First Nation, Metis, Inuit, or 
Indigenous person.



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[ccp4bb] 2-year post-doc in membrane protein structural biology available at Lund University

[Pontus Gourdon]

Dear all,

We have an open post-doc position in membrane protein structural biology (at 
Lund University, Sweden). Details are available below.

Do not hesitate to contact us if you have questions regarding the position.

Best wishes,

Pontus


Pontus Gourdon, M.Sc., Ph.D., Wallenberg Academy Prolongation Fellow, Lundbeck 
Foundation Ascending Investigator
*
Senior lecturer (lektor) | Dept. of Experimental Medical Science | Lund 
University
Sölvegatan 19 | Office C1320b | SE - 221 84 Lund | Sweden

Associate Professor (lektor) | Dept. of Biomedical Sciences | University of 
Copenhagen
Mærsk Building, Nørre Allé 14 | Office 07-9-75 | DK - 2200 Copenhagen | Denmark

Tel.: +46 739 959856 or +45 5033 9990
Email: pontus.gour...@med.lu.se or pon...@sund.ku.dk
Zoom: https://lu-se.zoom.us/my/pontus.gourdon
Google scholar: rb.gy/tdar1i
Web-LU: rb.gy/y2nkpp
Web-KU: rb.gy/bshuqp
*



Work profile:
The successful applicant will perform experimental research to understand how 
membrane proteins belonging to the TRP-channel family are regulated in normal 
and pathophysiology using single particle cryo-EM. You should be creative, with 
good interpersonal and collaborative skills, power of initiative, and a high 
degree of independence. In particular, it is preferred if you master cloning, 
production, purification and analysis of membrane proteins as well as sample 
preparation, data collection, processing and analysis for determination of 
cryo-EM structures. The research will be supervised by Prof. Peter Zygmunt in 
collaboration with Assoc. Prof. Pontus Gourdon.

Selected publications from 2022 & 2021 from the two groups:
• Zhang et al (2022) Nature Communications 13(1):7483
• Moparthi et al (2022) Nature Communications 13(1):6113
• Salustros et al (2022) Nature Communications 13(1):5121
• Li et al (2022) Nature Communications 13(1):4339
• Wiuf et al (2022) Science Advances 8, eabn4331
• Grønberg et al (2021). Elife 10:e73124
• Li et al (2021) Nature Communications 12(1):3973
• Wang et al (2021) Nature Communications 12(1):2956

Preliminary start date:
As soon as possible

Supervisor/contact person:
Peter Zygmunt, +46 (0)46-222 69 06, peter.zygm...@med.lu.se
Pontus Gourdon, +46 (0)739-95 98 56, pontus.gour...@med.lu.se

(Preferred) qualifications:
• To candidate must hold a PhD degree within a relevant field, and the degree 
cannot be older than three years.
• Experience of cloning, production and purification of membrane proteins.
• Experience of single particle cryo-EM on membrane proteins including the 
preparation and freezing of protein samples.
• Experience of screening samples using “state-of-the-art” electron microscopes 
such as Talos, Glacios and Krios.
• Experience of publication of cryo-EM structure studies.
• Experience of interdisciplinary collaborations.
• Excellent knowledge of written and spoken English.

Written application, including reference number, is to be sent via e-mail to 
the supervisors and must include the following:
• CV
• Personal letter stating the reasons why the study suits the applicant 
(maximum one page)
• List of publications
• References (2)
• Indicate the reference number (V2022/1491) in the email and in the attached 
application





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[ccp4bb] 2 PhD position in Structural Biology, University of Münster, Germany

[Kümmel , Daniel]

Our group at the Institute of Biochemistry, University of Münster, is seeking 
to fill two PhD student position. We are looking for motivated candidates with 
a background in biochemistry and/or structural biology. The fixed-term 
DFG-funded posts are available immediately for a 3 year period.



We are interested in molecular mechanisms of regulatory protein complexes in 
intracellular transport and signaling. The projects involve protein structure 
determination supported by biophysical, biochemical and cell biological 
experiments. For more information, please see our recent publications (Fitzian 
et al., Mol Cell 
2021;
 Klink et al., PNAS 
2022) or visit 
https://www.uni-muenster.de/Chemie.bc/en/forschung/kuemmel/index.html.



Embedded in the vibrant atmosphere of Münster with its high standard of living 
and with a diverse research profile and attractive study programs, the 
University of Münster draws students and researchers throughout Germany and 
from around the world. The newly established cryo-EM facility with a 
state-of-the-art Kiros microscope provides excellent conditions for structural 
biology research.



To apply see official job posting (scroll down for English version): 
https://www.uni-muenster.de/Rektorat/Stellen/ausschreibungen/st_20220912_sk9.html







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[ccp4bb] 2-year post-doc in membrane protein structural biology available at Lund University

[Pontus Gourdon]

Dear all,

We have an open post-doc position in membrane protein structural biology at 
Lund University, Sweden. Full details are available below.

The closing date for applications is the 31st August.

Do not hesitate to contact us if you have questions regarding the position.

Best regards,

Pontus


Pontus Gourdon, M.Sc., Ph.D., Wallenberg Academy Prolongation Fellow, Lundbeck 
Foundation Ascending Investigator
*
Senior lecturer (lektor) | Dept. of Experimental Medical Science | Lund 
University
Sölvegatan 19 | Office C1320b | SE - 221 84 Lund | Sweden

Associate Professor (lektor) | Dept. of Biomedical Sciences | University of 
Copenhagen
Mærsk Building, Nørre Allé 14 | Office 07-9-75 | DK - 2200 Copenhagen | Denmark

Tel.: +46 739 959856 and +45 5033 9990
Email: pontus.gour...@med.lu.se and pon...@sund.ku.dk
Google scholar:  
rb.gy/tdar1i
Web-LU:  
rb.gy/y2nkpp
Web-KU: 

 rb.gy/bshuqp
*




Work profile
The successful applicant will perform experimental research to understand how 
membrane proteins belonging to the TRP-channel family are regulated in normal 
and pathophysiology using single particle cryo-EM. You should be creative, with 
good interpersonal and collaborative skills, power of initiative, and a high 
degree of independence. In particular, you must master cloning, production, 
purification and analysis of membrane proteins as well as sample preparation, 
data collection, processing and analysis for determination of cryo-EM 
structures. In addition, experience of composing and writing manuscripts is 
considered of importance.

Research environment
The research will be supervised by Prof. Peter Zygmunt in collaboration with 
Assoc. Prof. Pontus Gourdon, together providing the necessary academic 
knowledge and laboratory equipment facilities as well as national and 
international academic networks to successfully investigate the 
structure-function relationship of TRP channels, and in particular the 
requirements for ligand gating mechanisms of TRP channels involved in various 
cellular processes. Prof. Peter Zygmunt has over a time period close to 25 
years established an internationally recognized translational research 
environment at Lund University, focusing on both clinical and molecular aspects 
of TRP channel regulation with prime interest in pain signaling and secretory 
cell signaling. Assoc. Prof. Pontus Gourdon offers know-how in membrane protein 
structural biology. The group of Assoc. Prof. Gourdon is located to Lund 
University as well as to University of Copenhagen.

Selected recent publications from the two groups:

  *   Li et al. (2022) Structures of Atm1 provide insight into [2Fe-2S] cluster 
export from mitochondria. Nature Communications 13(1):4339
  *   Wiuf et al. (2022) The two-domain elevator-type mechanism of 
zinc-transporting ZIP proteins. Science Advances 8, eabn4331
  *   Moparthi et al. (2021). The human TRPA1 intrinsic cold and heat 
sensitivity involves separate channel structures beyond the N-ARD domain. 
bioRxiv preprint doi: https://doi.org/10.1101/2021.07.31.454589; 2021
  *   Grønberg et al. (2021). Structure and ion-release mechanism of PIB-4-type 
ATPases. Elife 10:e73124.
  *   Li et al. (2021). Structure and transport mechanism of P5B-ATPases. 
Nature Communications 25(12):3973
  *   Wang et al. (2021). Cryo-EM reveals the architecture of placental malaria 
VAR2CSA and provides molecular insight into chondroitin sulfate binding. Nature 
Communications 12:2956.
  *   Moparthi and Zygmunt PM (2020). Human TRPA1 is an inherently 
mechanosensitive bilayer-gated ion channel. Cell Calcium. 91:102255.


Scholarship period: The scholarship covers a period of maximum 24 months.



Application deadline: August 31st, 2022



Preliminary start date: October 1st, 2022, or according to agreement



Supervisor/contact person:

Peter Zygmunt, +46 (0)46-222 69 06, peter.zygm...@med.lu.se

Pontus Gourdon, +46 (0)739-95 98 56, pontus.gour...@med.lu.se



Qualifications:

  *   To be eligible for a post-doc scholarship at Lund University the 
recipient must hold a PhD degree within a relevant field. The PhD degree must 
not be from Lund University. The PhD degree must not be older than three years, 
unless special reasons may be invoked such as: illness, parental leave, 
commission of trust, military/civil defense service or similar missions. The 
applicant must not have been employed at Lund University in the past two years.
  *   PhD in structural biology, protein chemistry or equivalent research 

[ccp4bb] **2 Days left to register for the CCP-EM Spring Symposium 2022**

[Anna Clark - STFC UKRI]

Dear CCP-EMers,

You have just 2 days left to register for the CCP-EM Spring Symposium 3-5 May 
2022.

You can register at: https://cvent.me/449Ozw

There is accommodation still available for the event so if you have any 
difficulties in booking accommodation through the registration page, please do 
not hesitate to contact me.

Kind regards
Anna Clark

CCP-EM Symposium Organising Committee
Scientific Computing Department
Science and Technology Facilities Council
Email: ccpemeve...@stfc.ac.uk

[cid:image001.png@01D84024.EC42F100]



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[ccp4bb] 2 opened positions at ZoBio, NL

[Inês Justo]

Hi everyone,

ZoBio (www.zobio.com) offers innovative research services 
in the field of small-molecule drug discovery to the pharmaceutical and biotech 
industries. Our international team of over 35 people covers four fields of 
expertise: Protein Engineering and Production, Assay Development and Screening, 
Structural Biology and Medicinal Chemistry.

Currently we have 2 positions opened that might interest the CCP4BB community:


  *   Scientist in NMR-based RNA Drug Discovery (PhD), for a collaborative 
project involving ZoBio and Peter Güntert's and Roland Riek's groups at the ETH 
Zürich (job listing: 
https://zobio.com/careers/scientist-in-nmr-based-rna-drug-discovery-phd/)
  *   Senior Scientist Medicinal Chemistry (PhD) (job listing: 
https://zobio.com/careers/senior-scientist-medicinal-chemistry/)

If you or anyone in your circle would be interested in applying to either 
position, please send your application (CV, motivation letter and names of 
potential referees) to h...@zobio.com, clearly 
mentioning the job you're applying to in the subject line.

Best,
Inês Justo

Inês Justo
Researcher
T +31-71-2040580
ZoBio B.V. •
J.H. Oortweg 19
2333 CH
Leiden •
The Netherlands



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[ccp4bb] 2 Bruker AXS Crystal Farm Imaging System w/ Computer & Software looking for a new home

[Inês Justo]

Hi everyone,

Our lab is going through upgrades and some of our current equipment will lose 
its place in our workflow. Particularly, this is the case of 2 Crystal Farm(tm) 
imaging systems, that are in working condition but can't be integrated with the 
rest of our new equipment. It would be a shame to throw away perfectly 
functioning equipment so we would prefer to find them a new home (preferably by 
the end of March)!

Some general information about Crystals Farms(tm):
"The Crystal Farm (tm) imaging system simplifies and automates protein 
crystallization by integrating incubation at chosen temperatures together with 
optical imaging of the crystal growth plates at predetermined intervals. At the 
core of the Crystal Farm is a high-resolution imaging system that can quickly 
and consistently image hanging, sitting, or micro-batch drops in virtually all 
plate types. System control and image analysis can be directly or remotely 
accessed via Crystal Navigator, Crystal Farm's scalable web-based software."

Each Crystal Farm(tm) comes with its own computer, screen and keyboard. Both 
computers have the Crystal Navigator software already installed.

Don't hesitate to contact me at iju...@zobio.com if 
the Crystal Farms(tm) interest you. I'm happy to provide pictures and further 
information.

Best regards,
Inês Justo


Inês Justo
Researcher
T +31-71-2040580
ZoBio B.V. •
J.H. Oortweg 19
2333 CH
Leiden •
The Netherlands



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[ccp4bb] 2 PhD positions in Structural Mitochondrial Biology at CPR, University of Copenhagen

[Eva Kummer]

Dear colleagues,

2 PhD positions in structural biology of mitochondria will be available in my 
newly established lab at the Novo Nordisk Center for Protein Research (CPR) at 
University Copenhagen. Our group has a deep interest in understanding the 
biology of human mitochondria with a specific focus on how these important 
organelles maintain their DNA and how they produce functional RNA species. The 
candidates will employ single-particle cryo-EM to understand the structure and 
working principles of mitochondrial machines involved in these processes.

We are looking for highly motivated candidates that are eager to acquire new 
methodology and have a genuine interest in understanding molecular mechanisms. 
At CPR, you will join an interdisciplinary, collaborative and supportive 
environment. The institute provides access to state-of-the-art infrastructure 
and instrumentation including a Titan Krios and a Glacios both equipped with 
Falcon III DED, as well as multiple smaller screening instruments. In addition, 
the center entertains a number of core facilities including protein production, 
crystallography, biophysics, high performance computing, mass spectrometry, and 
genomics. So you will find everything that is needed to help you succeed.
For informal inquiries, please contact me directly: 
eva.kum...@cpr.ku.dk. Applications, however, will 
have to be submitted via the online portal: 
https://employment.ku.dk/phd/?show=153662

For further information about the lab, please refer to:
https://www.cpr.ku.dk/research/protein-structure-function-program/kummer/

Application deadline is 11 April 2021!

I would appreciate if you could forward this advertisement also to interested 
candidates that may not be part of the mailing list. Thank you!

All the best,
Eva




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[ccp4bb] 2 PhD positions in Mainz/Germany

[Wolf, Eva]

Dear all,

I am looking for two PhD students to join our research group in Mainz/Germany.

Here is the ad:

2 PhD positions in Structural Biology at JGU/IMB Mainz, Germany

Two PhD positions are available in the group of Eva Wolf at the Johannes 
Gutenberg University (JGU) and

the Institute of Molecular Biology (IMB) in Mainz, Germany. Research in the 
Wolf group is focused on the

structural, biochemical and biophysical analysis of proteins involved in 
circadian (day-time dependent)

regulation and light-synchronization.

To elucidate the molecular mechanisms underlying circadian regulation, the PhD 
student will apply a wide range

of techniques including 3D-structural analyses (e.g. X-ray crystallography, 
Cryo-EM, SAXS, Crosslink-MS),

biochemical and biophysical protein interaction studies as well as UV/VIS 
spectroscopy. To produce highly pure

proteins and protein complexes for these applications, she/he will perform 
cloning, recombinant protein expression

(E.coli, insect cells) and protein purification using FPLC systems. Within 
collaborations, she/he will also analyze

clock protein functions in cell-based approaches and in vivo systems.

Candidates with a strong interest in structural biology, protein biochemistry, 
protein structure-function relationship

and a significant previous exposure to these research areas during their master 
education are encouraged to apply.


Please send your application including your CV, motivation letter, certificates 
and contact details for 2 references in

one pdf-file to Eva Wolf (evawo...@uni-mainz.de). 
The deadline for this application is November 4th 2020.


The prospective PhD student will also be affiliated with IMB’s International 
PhD program (IPP) and must have a

good command of English. PhD candidates must also apply to the International 
PhD Programme

(IPP, https://www.imb.de/students-postdocs/international-phd-programme).

The deadline for registration at the IPP is November 27th 2020.


With best regards,

Eva

Prof. Dr. Eva Wolf
Structural Chronobiology
IMB and University Mainz
Ackermannweg 4
55128 Mainz, Germany
evawo...@uni-mainz.de
https://www.imb.de/research/wolf/research/




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[ccp4bb] 2 days remaining for early bird registration - CCP-EM Spring Symposium VI - 27-29th April 2020

[Tom Burnley - UKRI STFC]

Dear all,

Two more days left for CCP-EM Spring Symposium early bird registration.

Last day for early bird registration is tomorrow - Friday, 21st February.  
After that the registration fee will increase!

Full details are available here:

http://www.cvent.com/d/8hqsdb

CCP-EM are proud to announce the sixth annual 'CCP-EM Spring Symposium'.  The 
conference aims to provide a forum to highlight state of the art developments 
in computational cryoEM and related themes as well as showcasing outstanding 
recent biological applications.  We aim to promote an inclusive, friendly 
atmosphere welcoming both old and new to the community.  Topics include 
instrument technology, sample preparation, image processing, single particle 
reconstruction, tomography and model building.  The schedule will also include 
the Diamond Light Source biological cryo-imaging user meeting for eBIC & B24.

The conference will be held 27-29th April 2020 at Nottingham University East 
Midlands Conference Centre.  Please note the change of venue (and caterers!) 
from last year.  Confirmed speakers include:

Gabriel Lander (Scripps)
Chris Russo (MRC-LMB)

Joe Atherton (KCL)
Chris Booth (Gatan)
Chun-wa Chung (GlaxoSmithKline)
Rouslan Efremov (VIB-VUB Center for Structural Biology)
Vicki Gold (University of Exeter)
Jeroen Keizer (Thermo Fisher Scientific)
Greg McMullan (MRC-LMB)
Alex Noble (NYSBC)
Gaia Pigino (Max Planck Institute of Molecular Cell Biology and Genetics)
Miroslava Schaffer (Max Planck Institute of Biochemistry)
Dimitry Tegunov (Max Planck Institute for Biophysical Chemistry)
Hongyi Xu (Stockholm University)

Plus what’s new at CCP-EM, EBI and eBIC

Scientific organisers:
Helen Saibil (Birkbeck)
Christos Savva (University of Leicester)

Best wishes from CCP-EM,

Tom, Colin, Agnel, Jola, Helen and Martyn





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[ccp4bb] 2 Postdoc positions available

[Guenter Fritz]

On behalf of Huib Ovaa (h.o...@lumc.nl):

We are looking for postdoc candidates with a background in protein 
chemistry/ structural biology.


There are two projects: One project on MHC-T-cell interactions, and 
diagnostics/ immunotherapy using novel sets of protein reagents that we 
are developing.


The other project is on making Ub system probe molecules for various 
targets, requiring assay development, structures in a collaborative 
project with the screening and medicinal chemistry teams in the Ovaa lab 
(http://www.ovaalab.nl )


The candidates should have a strong background in expression and 
purification of proteins and structural biology / X-ray crystallography.


Please direct applications to Huib Ovaa:

Prof. Dr. Huib Ovaa │group leader chemical biology and small molecular 
screening │Oncode Institute & Leiden University Medical Center (LUMC) 
│Department of Cell and Chemical Biology │location T02.03 │


Einthovenweg 20 │2333 ZC Leiden, the Netherlands │email: h.o...@lumc.nl 
 │phone +31 71 5268721 │website lab 
http://www.ovaalab.nl  │website department 
https://ccb.lumc.nl/








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[ccp4bb] 2-year postdoctoral position available - Structural Microbiology, Institut Pasteur

[Marco BELLINZONI]

Dear all,
A 2-year post-doc position is currently available at the Structural 
Microbiology Unit, located at the Institut Pasteur in Paris.
Our team has been working on the molecular mechanisms underlying the metabolic 
plasticity of Actinobacteria, with a special emphasis on the signaling pathways 
involved (for an overview of the topic and our recent work, please see Wagner 
et al., Sci. Signal., 2019; Bellinzoni et al., Genes Immun., 2019). The 
postdoctoral fellow will join an active and multidisciplinary environment, 
working on Corynebacterium glutamicum enzymes and protein complexes involved in 
central metabolism, and applying an integrative structural biology approach in 
which cryo-EM plays a key role. The project is part of a French-German 
initiative funded by the respective national research agencies (ANR and DFG), 
and will be performed in collaboration with the groups led by Profs. Michael 
Bott (Forschungszentrum Jülich) and Bernhard Eikmanns (University of Ulm).
The Structural Microbiology Unit is fully equipped for microbiology and protein 
biochemistry work, and has a well-established network of collaborations. In 
addition, the institute’s campus provides a vibrant scientific life as well as 
access to excellent core facilities. A full range of state-of-the-art equipment 
for structural biology and biophysics is available, including a Titan Krios and 
two Glacios microscopes currently undergoing installation. The unit has also 
regular access to synchrotron beamlines for X-ray crystallography and SAXS.
The position is open from October 2019, although the starting date may be 
arranged. The ideal candidate is an enthusiastic PhD with a good publication 
record and a solid background in protein biochemistry and biophysics. Good team 
spirit and presentation skills in English are essential; experience in dealing 
with large macromolecular complexes, protein-protein interaction studies and/or 
cryo-EM would be an asset. Interested candidates should provide a full CV with 
a summary of previous research experience, a brief statement of interest on the 
position and contacts of a couple of referees to marco (dot) bellinzoni (at) 
pasteur (dot) fr. Please send applications or informal enquiries no later than 
June 5.
Best regards,
Marco

===
Marco Bellinzoni
Unité de Microbiologie Structurale
Institut Pasteur
25, rue du Dr. Roux
75724 Paris Cedex 15
France
Tel: +33 (0)1 45688608
Fax: +33 (0)1 45688604
===






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[ccp4bb] 2 postdoctoral fellowships available to study the structure and evolution of viral proteins at Linköping University, Sweden

[Eleonore von Castelmur]

Dear colleagues,

I have two postdoctoral fellowships available in my group.  Please see below 
for the details and feel free to spread it to anyone you think might be 
interested and suitable for the positions.

All the best,
Eleonore


Postdoctoral fellowships to study structural and functional evolution of viral 
proteins
The von Castelmur lab at the Department of Physics, Chemistry and Biology (IFM) 
and part of the Wallenberg Center for Molecular Medicine at Linköping 
University, Sweden, is looking to recruit up to two postdoctoral fellows 
(2-year projects) to study the evolutionary relationship and functional 
repurposing of human proteins acquired by picornaviruses (through horizontal 
gene transfer).
The overall goals of these particular projects are to continue the structural 
and functional characterisation, already begun in the lab. The projects will 
involve molecular biology, biochemistry and biophysics in combination with 
structural biology techniques (in house access to a variety of techniques 
through ProLinC https://liu.se/en/research/prolinc). Therefore, we seek highly 
motivated individuals with practical experience and expertise in cloning and 
protein production (expression, purification, characterization), structural 
biology (experience in at least one technique is required) and an interest in 
learning new methods and skills.

Qualifications and requirements to applicants:


  *   Scholarship may be granted only to non-Swedish citizens with a PhD or 
equivalent acquired in another country than Sweden. The applicant must not have 
been employed by Linköping University previously.
  *   The applicant must have or be about to receive a doctoral degree in a 
subject relevant to the research project (e.g. structural biology, molecular 
biology, biochemistry, biophysics, chemistry, or a related area) and needs to 
be passionate about research. Problem solving ability and creativity are 
essential.
  *   Documented ability to write scientific manuscripts (one or more first 
author papers from Ph.D. and postdoctoral studies will be highly valued)
  *   Excellent English interpersonal, communication and writing skills
  *   Ability to operate both independently but also as a team player in a 
multi-disciplinary environment

Application
The application should consist of the following:
1. A short (maximum 1 A4 page) cover letter, explaining the motivation to 
apply for the position.
2. The CV of the applicant, including a list of published peer-reviewed 
articles.
3. Statement of Research Interests, max 2 pages
4. Copies of the PhD diploma (or equivalent).
5. Contact details for 2-3 references, one of which should be your PhD 
supervisor.
The duration of the fellowship is 2 years. Your application should be written 
in English and prepared as a package in PDF format, to be submitted to 
eleonore.von.castel...@liu.se. Make sure 
to use the subject line: “application for postdoctoral fellowship 
IFM-2019-00239” in the application email. Submit the application on May 21st, 
2019 at the latest. The top ranked candidates will be contacted within three 
weeks from the closing date for an interview. Starting date according to 
agreement. For more information, contact Dr. Eleonore von Castelmur.
Email: eleonore.von.castel...@liu.se
Webpage: https://liu.se/en/employee/elevo74



Eleonore von Castelmur, PhD
Biträdande lektor
Department of Physics, Chemistry and Biology (IFM)
Linkoping University
SE-581 83 Linköping
phone: +46 13 281966
e-mail: eleonore.von.castel...@liu.se




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[ccp4bb] 2 positions around XChem-related compound design

[Frank von Delft]

Dear all, I have two open to work on fragment/XChem-related methodology 
for structure-based compound design.


Team Leader (applications close next *Weds 1st May*):  full ad here 
, 
summary:


   /We are recruiting an experienced computational chemist or
   scientific programmer, to head the Fragalysis project for automating
   fragment hit progression, part of the XChem collaboration between
   SGC and Diamond...  The //Fragalysis
   //project leader will be tasked
   with converting the existing proof-of-concept tool into a
   production-level system that is routinely usable for analysing XChem
   results and designing and acquiring follow-up compounds. This will
   entail setting the scientific direction and priorities of the
   project through close and continuous interaction with expert and
   novice users; coordinating a growing team of scientific programmers
   and contractors; liaising with and expanding a wide and
   international set of collaborators and contributors; securing
   further funding for the project; helping supervise students; and
   developing specific methodologies of their own./


Postdoc (closing *Weds 15th May*):  full advert here 
, 
this is a summary:


   /This role will be tasked with the design and acquisition of
   follow-up compounds based on fragment screening hits from the Target
   Enabling Package (//www.thesgc.org/tep
   //) and Ultra-DD (//www.ultra-dd.org
   //) programs. The successful candidate will
   coordinate experimental validation of the newly designed compounds
   with collaborating scientists in order to progress them towards
   potent molecules.
   /

Cheers
Frank


--
Prof Frank von Delft
Associate Professor Principal Investigator: Protein Crystallography
Structural Genomics Consortium
Oxford University
+44 1865 617583 (office: W,F)

Principal Beamline Scientist: I04-1
Diamond Light Source
+44 1235 778997 (office: M,T,T)
+44 7471 026103 (mobile)



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[ccp4bb] 2 Postdoctoral Fellowships in Structural Biology and Drug Development at the University of Oslo, Centre for Molecular Medicine Norway (NCMM)

[Luecke, Hartmut]

Structural Biology and Drug Development at the University of Oslo

[cid:45310D88-A655-46CE-828B-07D61B8B9026]

2 Postdoctoral Fellowships

Inhibitor discovery targeting the Helicobacter pylori pH acclimation system (a 
pH-gated urea channel and a cytoplasmic urease)1
1Strugatsky et al. “Structure of the proton-gated urea channel from the gastric 
pathogen Helicobacter pylori” (2013) Nature 493, 255–258.

Online application required, deadline 28 Feb 2019:

https://www.jobbnorge.no/en/available-jobs/job/164159/two-2-postdoctoral-fellowships-in-structural-biology-and-drug-development

--
Prof. Hartmut Luecke
Structural Biology and Drug Discovery Group
Norwegian Centre for Molecular Medicine (NCMM), Nordic EMBL Partnership
and Institute of Clinical Medicine, University of Oslo
Dept. of Medical Biochemistry, Oslo University Hospital
Oslo, Norway




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888-456-7006 immediately if you have received this e-mail in error. E-mail 
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[ccp4bb] 2 postdoctoral fellowships available to study Type 4 Secretion Systems at Umeå University, Sweden

[Ronnie Berntsson]

Dear colleagues,

I have two postdoctoral fellowships available in my group.  Please see below 
for the details and feel free to spread it to anyone you think might be 
interested and suitable for the positions.

Best wishes,
Ronnie


Postdoctoral fellowships to study Type 4 Secretion System

The Berntsson lab at the department of Medical Biochemistry and Biophysics at 
Umeå University, Sweden, is looking to recruit up to two postdoctoral fellows 
(2-year projects) to study the structural and functional aspects of Type 4 
Secretion Systems. These large protein complexes are responsible for horizontal 
gene transfer between bacteria. As such, they facilitate the spread of, among 
other genes, antibiotic resistance between bacteria, both intra- and 
interspecies.
The overall goals of these particular projects are to continue the structural 
and functional characterisation, already begun in the lab, of the i) the 
adhesion proteins and ii) the DNA processing proteins of G+ Type 4 Secretion 
Systems. The projects will involve molecular biology, biochemistry and 
structural biology techniques, with an early emphasis on the functional 
characterization of these proteins and their complexes.
Qualifications
The applicants must possess a PhD, or another diploma deemed equivalent to a 
PhD, within molecular biology, biochemistry, structural biology or a related 
field. Furthermore, the applicant shall have practical experience and expertise 
of cloning and protein production and purification in bacteria. The applicant 
should preferably be experienced with functional studies of (membrane) proteins 
using various molecular biology and biochemical methods, such as ITC, SPR, 
fluorescence spectroscopy and microscopy, as well as having experience with 
protein crystallography. Previous experience of working with membrane proteins 
is an advantage, as is previous experience of fluorescence microscopy and 
electron microscopy. The applicants must have a very good level of English, 
both written and spoken. The applicants are also expected to be good team 
players, but should also be able to work independently.
Application
The application should consist of the following:

1. A short (maximum 1 A4 page) cover letter, explaining the motivation to 
apply for the position.

2. The Curriculum Vitae of the applicant, including a list of published 
peer-reviewed articles.

3. Copies of the PhD diploma (or equivalent).

4. Contact details for three references, of which one should be your PhD 
supervisor.

The duration of the fellowship is 2 years. Your application should be written 
in English and prepared as a package in PDF format, to be submitted to 
ronnie.bernts...@umu.se. Make sure to use the 
subject line: “postdoc application T4SS” in the application email. Submit the 
application on January 15, 2019 at the latest. The top ranked candidates will 
be contacted within three weeks from the closing date for an interview. 
Starting date according to agreement. For more information, contact Dr. Ronnie 
Berntsson.
Email: ronnie.bernts...@umu.se
Webpage: https://www.biostruct.umu.se/principal-investigators/ronnie-berntsson/




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[ccp4bb] 2 postdoctoral positions- structural biology of ubiquitin signaling

[Shaun Olsen]

Dear Colleagues,
 
My laboratory is seeking to fill two postdoctoral positions that are 
immediately available for highly motivated biochemists/structural biologists 
interested in studying molecular mechanisms of signaling by ubiquitin and 
ubiquitin-like proteins.  

Posttranslational modification of proteins by ubiquitin and ubiquitin-like 
modifiers occurs through the sequential activities of a cascade of enzymes and 
a major focus of the laboratory is to understand the structural basis by which 
this enzymatic machinery functions.  We address these issues using a 
multidisciplinary approach that combines X-ray crystallography, 
biochemical/biophysical techniques, and cell-based studies.  Candidates should 
hold a PhD in a relevant field with demonstrated expertise in X-ray 
crystallography and/or the biochemical analysis of protein ubiquitination.

MUSC is well-equipped for all aspects of X-ray crystallography, including 
institutional membership of the SER-CAT facility at the Advanced Photon Source. 
 We have a vibrant and growing program in structural biology and work in a 
highly collaborative environment. The University is located in historic 
Charleston, SC where the weather is beautiful year-round.  There are several 
beaches within minutes of the city and the mountains are only three hours away. 
 In addition to these amenities, the art, history, food, and festivals make 
Charleston a fantastic place to work and live.

Interested candidates should e-mail a cover letter, CV, and the names of three 
references to olse...@musc.edu and apply online at 
http://careers.pageuppeople.com/756/cw/en-us/job/510945/univ-postdoctoral-scholar-biochemistry-molecular-biology.

The positions will remain open until filled.
 
Best Regards,

-Shaun

-
Shaun K. Olsen, PhD
Assistant Professor
Dept. of Biochemistry & Molecular Biology
Medical University of South Carolina
Charleston, SC 29425
olse...@musc.edu

List of Publications-- 
https://www.ncbi.nlm.nih.gov/myncbi/browse/collection/48468424/?sort=date=descending



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Re: [ccp4bb] 2 Scientists (f/m/diverse) at Beamline P11, PETRA III

[Heinrich Zimmermann]

2 Scientists (f/m/diverse) at Beamline P11, PETRA III

We are seeking two highly motivated scientists (f/m/diverse) to enhance
our macromolecular crystallography research team at this state-of-the-art
beamline at DESY in Hamburg, Germany.

DESY is one of the world’s leading research centres for photon science,
particle and astroparticle physics as well as accelerator physics. More
than 2400 employees work at our two locations Hamburg and Zeuthen in
science, technology and administration.

Looking back on a long tradition in research with synchrotron radiation,
DESY is one of the leading centres in the field of photon science
worldwide. With the storage ring PETRA III and the Free-Electron-Laser
FLASH, DESY offers a unique combination of photon sources to the
scientific community. PETRA III, one of the most brilliant hard X-ray
facilities worldwide, currently provides 20 undulator beamlines for
experiments utilizing the extreme source brilliance. The 'Bioimaging and
Diffraction Beamline P11' provides extremely high flux denisities allowing
for ultra-fast 3D structure determination of biological samples.

What we offer:

·   Develop and pursue own independent research projects in the field
of macromolecular and serial crystallography

·   Commissioning of new instrumentation and implementation of new
techniques and software applications at the beamline

·   Work in an interdisciplinary team in very close collaboration with
the user community

·   User support at P11

What we're looking for:

·   PhD in biochemistry, chemistry or a related field

·   Strong background in X-ray crystallography and protein structure
determination using synchrotron radiation and/or free electron lasers are
required

·   Good experimental skills and strong interest in instrumentation
development are beneficial

·   Programming skills in Python or C++ would be an asset

For further information please contact Dr. Anja Burkhardt 040-8998-1775,
 anja.burkha...@desy.de.

The position is limited to 2 years.

We are looking forward to your application (including CV, research
experience, and two names and contact information for references) via our
application system:  
www.desy.de/onlineapplication

Deutsches Elektronen-Synchrotron DESY

Code: FSPO020/2018

Notkestraße 85 | 22607 Hamburg Germany

Phone: +49 40 8998-3392

http://www.desy.de/career

Deadline for applications: 2018/12/11

With best regards

Heinrich Zimmermann

--

Heinrich Zimmermann

Personnel Officer HR Recruitment

Human Resources (V2)

Deutsches Elektronen-Synchrotron DESY

A Research Center of the Helmholtz Association

Notkestr. 85, 22607 Hamburg

phone: 040-8998-1589

fax: 040-8998-3282

email: heinrich.zimmerm...@desy.de

web: http://www.desy.de

for guests: building 07 room 502



WE ARE RECRUITING!

Become a Part of us. You can find our current job openings right here:
www.desy.de/jobs

We are looking forward to your application!




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[ccp4bb] 2 crystallography posts available at Evotec

[McEwan, Paul]

Dear All,
There are two senior scientist posts available at Evotec in Abingdon, UK. 
Please do not contact me directly for application, please use the online 
recruitment weblink at the base of this email.




Evotec is a leader in the discovery and development of novel small molecule 
drugs with operational sites in Europe and the US. The Company has built 
substantial drug discovery expertise and an industrialised platform that can 
drive new innovative small molecule compounds into the clinic. In addition, 
Evotec has built a deep internal knowledge base in the treatment of diseases 
related to anti-infective, neuroscience, pain, oncology, inflammation and 
metabolic diseases. Leveraging these skills and expertise the Company intends 
to develop best-in-class differentiated therapeutics and deliver superior 
science-driven discovery alliances with pharmaceutical and biotechnology 
companies.
We are looking for highly motivated individuals for our Abingdon site to work 
as a
Senior Scientist, Structural Biology, X-Ray Crystallography (2 x 12-month 
temporary contract)
Evotec (UK) Ltd is currently seeking to add to our Structural Biology 
Department.  The group works closely with our Discovery Chemistry Department 
and with clients to develop novel small molecule drugs.  The group is at the 
forefront of new science and technology, and is seeking to expand as business 
needs grow.  Our site is located less than 4 miles from Diamond Light Source 
and eBIC national facilities for access to synchrotron radiation and Cryo 
Electron Microscopy respectively to support our high-end analysis of samples.
The position is initially temporary, for 12 months duration, but may become 
permanent dependant on business need.
Required Knowledge, Skills and Abilities:

  *   Expertise in X-ray crystallography from crystal preparation and handling, 
data collection through to analysis of structures
  *   Experience in gene design and protein purification
  *   Self-motivated, enthusiastic, cooperative and reliable
  *   Knowledge of basic laboratory techniques, and understanding of the 
science underlying the techniques and experiments
  *   Experience of working in a laboratory environment
  *   The ability to adapt to changing demands whilst operating under pressure 
to deadlines
  *   The ability to work accurately and with attention to detail
  *   Good interpersonal skills and the ability to work well with other 
scientific staff
  *   The ability to work well independently, and as part of a team
  *   Good organisational and time management skills
  *   Good verbal communication skills
  *   Ability to maintain excellent laboratory records
  *   Computer proficiency
Responsibilities may include:

  *   Supporting a project team by conducting experiments with defined, agreed 
objectives and timelines
  *   Contributing to the design, execution and interpretation of experiments 
in a project team to accomplish project goals
  *   Adapting scientific knowledge to resolve problems encountered in 
achieving defined goals with assistance from line manager or other team members 
to meet internal and project deadlines
  *   Preparing reports of findings, presenting data, and collaborating with 
other scientists at Evotec
  *   Presenting own work at project technical meetings, and department 
technical meetings when required
  *   Demonstrating full command of all techniques and tools required for 
assigned responsibilities within the given project
  *   Ensuring safe working practices of themselves and any direct reports
  *   Complying fully with the company safety policy (including COPs and SOPs) 
when performing experiments
  *   Reading scientific literature relevant to the project
  *   Adhering to Lab Notebook guidelines regarding accurate documentation of 
lab experiments
Desirable Knowledge, Skills and Abilities:

  *   Membrane protein expertise
  *   Cryo-Electron Microscopy sample preparation and data analysis
  *   Fragment based drug discovery
Education and Experience:


  *   PhD in Structural Biology, Biochemistry or related area



https://recruitment.evotec.com/VacancyDetails.aspx?FromSearch=True=QSAukis1tlc==738

best wishes,
Paul..
[cid:image002.png@01D41934.D23B4340]
Paul McEwan, Ph.D.
Principal Scientist, Structural Biology
+44 (0)1235 83 8802  (Direct)
+44 (0)1235 86 3139  (Fax)
paul.mce...@evotec.com
www.evotec.com

Evotec (UK) Ltd.
114 Innovation Drive,
Milton Park, Abingdon
Oxfordshire OX14 4RZ, UK


STATEMENT OF CONFIDENTIALITY.

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If received in error, please notify us immediately by reply email and then 
delete this email and any attachments from your system. Thank you!


Evotec (UK) Ltd is a limited company registered in England and Wales. 
Registration number:2674265. 

Re: [ccp4bb] 2 Open Positions (PhD Student + Post-Doc) in Oulu, Finland

[Petri Kursula]

Dear all,

I have been informed that the original links will eventually lead to the 
application system in the Finnish language, which might not be optimal for 
some. Here are links that will allow to apply in English:

post-doc
https://rekry.saima.fi/certiahome/open_job_view.html?did=5600=1=5769=en
 


PhD student:
https://rekry.saima.fi/certiahome/open_job_view.html?did=5600=1=5770=en
 


Sorry for the spam,
Petri




> On 31 May 2018, at 17:33, Petri Kursula  wrote:
> 
> Dear All,
> 
> my lab at the University of Oulu, Finland, has two open positions to be 
> filled in September. The positions are part of a multidisciplinary 
> collaborative project aiming at a comprehensive understanding of protein 
> structure/function and disease mechanisms in human hereditary neuropathies. 
> 
> The post-doctoral position is open for 2.5 years, and the PhD student 
> position for 4 years.
> 
> More information about the environment, project, etc., as well as links to 
> the application system can be found through the web pages below.
> 
> Post-doc:
> https://www.saimanet.com/certiahome/open_job_view.html?id=5769 
> 
> 
> PhD student:
> https://www.saimanet.com/certiahome/open_job_view.html?id=5770 
> 
> 
> Applications must be submitted through the electronic system, and 
> applications received by email will not be considered.
> 
> Best regards,
> Petri
> 
> 
> Petri Kursula
> --
> Professor 
> Department of Biomedicine
> University of Bergen, Norway
> http://www.uib.no/en/rg/petrikursula 
> 
> petri.kurs...@uib.no 
> --
> Group Leader, Adjunct Professor
> Faculty of Biochemistry and Molecular Medicine
> University of Oulu, Finland
> --
> 
> 
> 
> 
> 




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[ccp4bb] 2 Open Positions (PhD Student + Post-Doc) in Oulu, Finland

[Petri Kursula]

Dear All,

my lab at the University of Oulu, Finland, has two open positions to be filled 
in September. The positions are part of a multidisciplinary collaborative 
project aiming at a comprehensive understanding of protein structure/function 
and disease mechanisms in human hereditary neuropathies. 

The post-doctoral position is open for 2.5 years, and the PhD student position 
for 4 years.

More information about the environment, project, etc., as well as links to the 
application system can be found through the web pages below.

Post-doc:
https://www.saimanet.com/certiahome/open_job_view.html?id=5769 


PhD student:
https://www.saimanet.com/certiahome/open_job_view.html?id=5770 


Applications must be submitted through the electronic system, and applications 
received by email will not be considered.

Best regards,
Petri


Petri Kursula
--
Professor 
Department of Biomedicine
University of Bergen, Norway
http://www.uib.no/en/rg/petrikursula 

petri.kurs...@uib.no 
--
Group Leader, Adjunct Professor
Faculty of Biochemistry and Molecular Medicine
University of Oulu, Finland
--






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[ccp4bb] 2 Postdoc positions at Fondazione Ri.MED - Palermo

[caterina alfano]

2 PostDoctoral positions are available in the Structural Biology and
Biophysics Unit @ Fondazione Ri.MED (www.fondazionerimed.eu).

The successful candidates will carry out scientific projects in the field
of structural biology and biophysics aimed at understanding the molecular
mechanisms underlying oncological and neurodegenerative pathologies with
particular emphasis on drug discovery. In particular, the research activity
will aim to provide biophysical and structural information of biological
phenomena guided by protein folding, protein aggregation and
protein-protein interactions, with the ultimate goal of discovering new
drugs.

The Ri.MED seeks two candidates with specific skills on advanced
biophysical techniques such as nuclear magnetic resonance, calorimetry,
surface plasmon resonance, high resolution atomic force microscopy and
crystallography, complemented by consolidated technical and methodological
skills in molecular biology and biochemistry.

For more info about the positions, please visit
http://www.fondazionerimed.eu/Contents/Selezioni.aspx


*DEADLINE 13th MAY 2018*

Best Regards

Caterina



Caterina Alfano, PhD

Group Leader

Structural Biology and Biophysics Unit

Fondazione Ri.MED

Via Bandiera, 11

90133, Palermo - Italy

Tel:+39 091 604 / +39 091 23893179

Email: *calf...@fondazionerimed.com*

*www.fondazionerimed.eu *

[ccp4bb] 2 weeks to apply for 5 year postdoc with antimicrobial peptides

[Clarissa Czekster]

I am recruiting for a 5 year Wellcome Trust funded postdoc position in my lab 
at the University of St Andrews. The postdoc will work on a very 
multidisciplinary project using enzymology, chemical biology, x-ray 
crystallography and microbiology to study antimicrobial peptides.  

The add can be found in this link 
(http://www.jobs.ac.uk/job/BIO625/research-fellow-in-enzymology-ar2058sb/), and 
the position description and further particulars are below. 
--
Research Fellow in Enzymology - AR2058SB
University of St Andrews - School of Biology
Location:   St Andrews
Salary: £32,548 to £38,833 per annum
Hours:  Full Time
Contract Type:  Fixed-Term/Contract
Placed on:  20th March 2018
Closes: 20th April 2018
Job Ref:179139
Start: 1 July 2018 or as soon as possible thereafter

Fixed term for 59 months

We are seeking to appoint a post-doctoral research assistant in enzymology to 
work on the characterisation and engineering of enzymes involved in the 
biosynthesis and modification of peptide antimicrobials. The position is 
available in Dr Clarissa Czekster’s lab at the School of Biology/Biomedical 
Sciences Research Complex (BSRC) at the University of St Andrews. The post is 
for 59 months, funded by the Wellcome Trust.

The successful candidate will be a creative, well-motivated and ambitious 
scientist who has completed (or is about to complete) his/her PhD in 
Biochemistry or related fields, and will have a track record in cloning, 
expression and purification of recombinant proteins, enzyme kinetics, and tRNA 
biochemistry. Experience in x-ray crystallography, tRNA production, mass 
spectrometry and chemical biology techniques are desirable. She/he will have 
all the essential skills and several of the desirable skills, evidenced by a 
strong publication record, recommendation letters and interview. The successful 
candidate will have strong motivation, initiative, and aspiration to set up new 
techniques, interact with and mentor students.

The appointee will join the BSRC, a highly collaborative environment that 
brings together scientists from Biology, Chemistry, Physics, and Medicine. It 
offers state-of-the-art infrastructure for enzymology and structural biology: 
instrumentation for protein expression and purification; dedicated radiation 
rooms for manipulation of radiolabelled substrates; phosphorimager for 
radioactivity assays; spectrophotometers, stopped-flow spectrofluorometer, and 
a quenched-flow for enzyme kinetics; microcalorimeters and CD spectrometers for 
thermodynamics; surface-plasmon resonance for ligand screening; 2 computer 
clusters with 292 cores and university-wide software licenses for computational 
chemistry; several NMR and MS spectrometers; and a full crystallography suite 
including incubators with UV/VIS light imager for 600 plates nL-scale 
crystallization trials and 007HF rotating anode X-ray generator outfitted with 
cryostream and Saturn 944+ CCD detectors for crystal diffraction, and access to 
Diamond Light Source. There is also a large critical mass in enzymology, 
structural biology, medicinal chemistry, and microbiology within the BSRC, with 
12 groups working in those areas.

Informal inquiries are encouraged and can be sent to Dr Clarissa Czekster 
(cm...@st-andrews.ac.uk).

Applications are particularly welcome from women, who are under-represented in 
Research posts at the University.

The University is committed to equality for all, demonstrated through our 
working on diversity awards (ECU Athena SWAN/Race Charters; Carer Positive; 
LGBT Charter; and Stonewall). More details can be found at 
http://www.st-andrews.ac.uk/hr/edi/diversityawards/.

Interview Date:  30 April to 2 May 2018

Please quote ref:  AR2058SB

Closing Date:  20 April 2018

<>

[ccp4bb] 2. User Call for MAXIV BioMAX beamtime, period Dec. 2017-July 2018, Deadline September 7th

[Uwe Müller]

Dear all,
the first ultimate storage ring MAXIV in Lund, Sweden has opened the 2. user 
call to receive proposals requesting beamtime at BioMAX for the period 
Dec.2017-July 2018 until September 7, 2017.
In order to submit a new proposal, please visit this page:
https://www.maxiv.lu.se/users/open-calls/

BioMAX started its user operation in March 2017 and could successfully operate 
already around 50 proposals within a limited number of user operations. Within 
the next beam period we will ramp up the operations and will offer BioMAX to 
the broad international user community. The beam line is under continuous 
commissioning and will offer the following features during the next user period:


  *   20x5 µm^2 beam focus at sample position (can be further reduced by 
apertures)
  *   Average exposure time between 8-10 msec / frame
  *   Tuneable energy range 5-20 keV
  *   Initial sample changer capability using SPINE samples and ESRF pucks, 
later also UNIPucks possible with ISARA sample changer
  *   Eiger 16M hybrid pixel detector 130 Hz frame rate for 16M mode
  *   MD3 micro diffractometer
  *   HClab crystal dehydration device with fast nozzle changer for crystal 
dehydration and room temperature data collections
  *   MXCuBE3 experiment control software
  *   Automatic data processing during data collection
  *   Standard crystallographic software installed
  *   600 core HPC environment availalbe
  *   Sample preparation laboratory for crystal handling

MAXIV is member of the EU project iNEXT, which also supports travel and 
accommodation for international user groups (See also: 
http://www.inext-eu.org). On campus, we will have a guesthouse available, which 
can be booked via MAXIV before the beamtime as well.
We are looking forward for your beamtime proposals and the collaboration during 
your stay at MAXIV.

Uwe & the MAXIV MX-team!


Uwe Mueller
Group manager diffraction & scattering beamlines
BioMAX beam line manager

MAX IV Laboratory
Lund University
P.O. Box 118, SE-221 00 Lund, Sweden
Visiting address: Fotongatan 2, 225 94 Lund
Mobile:  +46(0)730-655268
E-mail: uwe.mul...@maxiv.lu.se
Url: www.maxiv.se

[ccp4bb] 2-year Postdoctoral Position available at The Institute of Cancer Research, London UK

[Rob Van Montfort]

The Institute of Cancer Research, London, is one of the world’s most 
influential cancer research institutes, with an outstanding record of 
achievement dating back more than 100 years. We provided the first convincing 
evidence that DNA damage is the basic cause of cancer, laying the foundation 
for the now universally accepted idea that cancer is a genetic disease. Today, 
The Institute of Cancer Research (ICR) leads the world at isolating 
cancer-related genes and discovering new targeted drugs for personalised cancer 
treatment. Under the leadership of our Chief Executive, Professor Paul Workman 
FRS, the ICR is ranked as the UK’s leading academic research centre. Together 
with our partner The Royal Marsden, we are rated in the top four cancer centres 
globally. The ICR is committed to attracting, developing and retaining the best 
minds in the world to join us in our mission – to make the discoveries that 
defeat cancer.
The Cancer Research UK Cancer Therapeutics Unit (CTU), within the Division of 
Cancer Therapeutics, is a multidisciplinary 'bench to bedside' centre, 
comprising around 160 staff dedicated to the discovery and development of novel 
therapeutics for the treatment of cancer. The Cancer Therapeutics Unit’s 
exciting goal is to discover high quality small molecule drug candidates and to 
progress these to clinical trial. All the scientific disciplines are in place 
to make this possible, including medicinal chemistry, biology, drug metabolism 
and clinical specialists who focus on new molecular targets emerging from human 
genome and ground breaking cell biology research.

A postdoctoral position is available in Dr Rob van Montfort’s Hit Discovery and 
Structural Design Team within the CTU. The Post-doc will be involved in 
high-throughput X-ray crystallography, fragment-based screening and 
structure-based drug design and will be responsible for protein expression, 
purification, crystallisation, structure determination and structural analysis 
of protein-ligand complexes from one of the CTU’s drug discovery programmes. 
The successful candidate will also be part of the Division of Structural 
Biology, in which the crystallographers in Dr van Montfort’s team are embedded, 
and will have access to state of the art crystallisation facilities, in-house 
X-ray sources and excellent access to synchrotrons. The successful candidate 
will interact closely with the biology, computational chemistry and medicinal 
chemistry teams at the CTU, and will therefore be expected to work across the 
two sites in Chelsea, London and Sutton, Surrey.

Applicants must have a PhD in a biological or physical science, and experience 
in macromolecular crystallography (to include protein biochemistry, protein 
crystallisation, & protein crystallography). Experience in molecular biology, 
protein expression in insect cells, structure-based drug design, and/or 
biophysics will be an advantage.



The starting salary will be in the range £29,960 to £36,830 p.a. inclusive 
(based on previous post-doctoral experience) and the post is offered on a fixed 
term contract of 2 years. Informal enquiries to 
rob.vanmontf...@icr.ac.uk or 
yann-vai.lebi...@icr.ac.uk. Closing date is 
July 9th 2017.

Please DO NOT send your application to Dr van Montfort or Dr Le Bihan; CVs must 
be submitted in line with the instructions below.

Dr. Rob van Montfort
Team Leader Hit Discovery and Structural Design
Joint Interim Head of Division of Structural Biology
Divisions of Cancer Therapeutics and Structural Biology
The Institute of Cancer Research
15 Cotswold Road
Sutton SM2 5NG
UK

Tel:
+44-(0)20-8722-4364 (Sutton)
+44-(0)20-7153-5142 (Chelsea)
Email: rob.vanmontf...@icr.ac.uk







The Institute of Cancer Research: Royal Cancer Hospital, a charitable Company 
Limited by Guarantee, Registered in England under Company No. 534147 with its 
Registered Office at 123 Old Brompton Road, London SW7 3RP.

This e-mail message is confidential and for use by the addressee only.  If the 
message is received by anyone other than the addressee, please return the 
message to the sender by replying to it and then delete the message from your 
computer and network.

[ccp4bb] 2 Wellcome Trust funded Post-Doc positions (4y) available in Berger group, University of Bristol, UK

[kapil gupta]

Dear CCP4bb and CCPEM members,

Up to two Research Associate positions in cellular structural biology of
transcription factors are available immediately in the Berger lab,
University of Bristol UK, funded by the Wellcome Trust.

As part of a dynamic interdisciplinary team, the Research Associates will
perform international leading basic research with the objective of
unlocking the structure, function and cellular assembly of key eukaryotic
transcription factor complexes, applying and integrating recombinant
multiprotein expression tools, structural biology (X-ray, EM), biophysics,
proteomics, cell biology and biochemistry techniques. Experience with
recombinant expression of multiprotein complexes, structural biology
methods (X-ray, EM) and cell biology techniques are highly
desirable.Experience with complex multicomponent human transcription
factors is a plus.

Applicants should hold, or expect to hold shortly, a PhD in biochemistry,
molecular biology, structural biology (X-ray, EM) or a related subject.

The Research Associates will benefit from the cutting-edge Bristol Biosuite
for structural biology and the Synthetic Biology centre (BrisSynbio,
www.bristol.ac.uk/brissynbio/) and synergize with our internationally
leading academic collaborators (Laszlo Tora, IGBMC; Patrick Schultz, IGBMC;
Marc Timmers, Utrecht; Christiane Schaffitzel, Bristol; and Juri
Rappsilber, Berlin).

For informal enquires please contact: Prof. Imre Berger 0044 117 39 41857,
imre.ber...@bristol.ac.uk


Closing date for applications is midnight Monday 1 May 2017.

For details follow link:

http://www.bristol.ac.uk/jobs/find/details.html?nPostingID=
5805=22027=28=DESC=1&
ID=Q50FK026203F3VBQBV7V77V83=ACAD102543=10=UK=
uobex
(Dr. Kapil Gupta on Behalf of)

*Imre Berger PhD HDR FRSB*
Professor of Biochemistry
Wellcome Trust Senior Investigator
Deputy Director, BrisSynBio Centre

School of Biochemistry
Biomedical Sciences Building
University of Bristol
University Walk
Bristol
BS8 1TD
imre.ber...@bristol.ac.uk 
Tel: 0044 (0) 117 39 41857
http://www.bris.ac.uk/biomedical-sciences/ 

A top 5 UK university with leading employers (2015)
A top 5 UK university for research (2014 REF)
A world top 30 university (QS Ranking 2014)

[ccp4bb] 2-Years PostDoc position at the Department of Pharmaceutical Sciences, Novara (Italy)

[Riccardo Miggiano]

A 2-years fellowship founded by Fondazione Cariplo is available for a
postdoc position at the Biochemistry and Structural Biology Unit of the
Department of Pharmaceutical Sciences (DSF) of University of Piemonte
Orientale in Novara, Italy (http://www.dsf.uniupo.it).



The Department of Pharmaceutical Sciences research activities focus on the
discovery and development of new bioactive compounds and the improvement of
their formulation and delivery. The Department comprises a wide range of
expertise and resources including pharmacology, chemistry, bioinformatics
and drug delivery technologies in a highly motivating interdisciplinary
environment.



We are seeking a strongly motivated candidate with skills in
biochemistry/enzymology and structural biology to carry out a research
program aimed at understanding the molecular aspects of *Mycobacterium
tuberculosis* DNA repair to disclose its role in the pathogenesis of
tuberculosis in humans. In particular, the postdoc will work on the
structural and biochemical characterization of recombinant proteins that
are key players in *M. tuberculosis *DNA repair machineries.

For the recruitment process, we require highly motivated candidates to send
a curriculum vitae and the name of one-two Referents within April 15th 2017
to:



*Prof.  Menico Rizzi (Head of DSF Biochemistry/Structural Biology Unit)*

Ph*:  +39 0321 375712 *

email*: **menico.ri...@uniupo.it* 

and

*Dr. Riccardo Miggiano (Referent of the scientific program)*

Ph*:  +39 0321 375715   *

email*: **riccardo.miggi...@uniupo.it* 

-- 
Riccardo Miggiano, Ph.D.
Department of Pharmaceutical Sciences
University of Piemonte Orientale
Via Bovio, 6
28100 Novara
ITALY

email: *riccardo.miggi...@uniupo.it *
phone: *+390321375813 <+39%200321%20375813>*

[ccp4bb] 2 year BBSRC funded PDRA position at the University of Liverpool, UK

[Antonyuk, Svetlana]

THE UNIVERSITY OF LIVERPOOL
FACULTY OF HEALTH AND LIFE SCIENCES
INSTITUTE OF INTEGRATIVE BIOLOGY
DEPARTMENT OF BIOCHEMISTRY
POSTDOCTORAL RESEARCH ASSOCIATE GRADE 7
£32,958 - £34,956 pa
An exciting opportunity has emerged in the Molecular 
Biophysics group to work on a BBSRC-supported 
project on structure-function-mechanism studies of Cu-nitrite reductase and 
membrane bound nitric oxide (NO) reductase and the role of metabolon complex 
formation in controlling levels of cytotoxic NO. The project will link 
crystallographic studies with techniques to probe factors that control delivery 
of electrons and protons to the active site of these enzymes. You will be 
responsible for using established molecular biology procedures underpinning the 
overexpression and purification of a number of enzymes and their mutants 
including membrane proteins and undertake crystallographic, spectroscopic and 
mechanistic aspects of the programme. You will have the opportunity to spend up 
to 4 weeks in the RIKEN laboratories in Japan as part of a collaborative 
programme alongside two PhD students working on membrane-bound nitric oxide 
reductases. You should have a PhD in the area of physics, chemistry, biological 
sciences or biophysics, with experience in protein crystallography and 
practical knowledge of molecular biology preferably with experience in membrane 
proteins. Excellent verbal and written communication skills are essential. The 
post is available for 2 years and the ability to commence immediately would be 
advantageous.

Job Ref: 006744 
Closing Date: 11 April 2017

For full details and to apply online, please visit: 
https://recruit.liverpool.ac.uk

[ccp4bb] 2 year PDRA position in University of Liverpool UK

[Antonyuk, Svetlana]

THE UNIVERSITY OF LIVERPOOL
FACULTY OF HEALTH AND LIFE SCIENCES
INSTITUTE OF INTEGRATIVE BIOLOGY
DEPARTMENT OF BIOCHEMISTRY
 POSTDOCTORAL RESEARCH ASSOCIATE GRADE 7
 £32,958 - £34,956 pa
An exciting opportunity has emerged in the Molecular 
Biophysics group to work on a BBSRC-supported 
project on structure-function-mechanism studies of Cu-nitrite reductase and 
membrane bound nitric oxide (NO) reductase and the role of metabolon complex 
formation in controlling levels of cytotoxic NO. The project will link 
crystallographic studies with techniques to probe factors that control delivery 
of electrons and protons to the active site of these enzymes. You will be 
responsible for using established molecular biology procedures underpinning the 
overexpression and purification of a number of enzymes and their mutants 
including membrane proteins and undertake crystallographic, spectroscopic and 
mechanistic aspects of the programme. You will have the opportunity  to spend 
up to 4 weeks in the RIKEN laboratories in Japan as part of a collaborative 
programme alongside two PhD students working on membrane-bound nitric oxide 
reductases
You should have a PhD in the area of physics, chemistry, biological sciences or 
biophysics, with experience in protein crystallography and practical knowledge 
of molecular biology preferably with experience in membrane proteins. Excellent 
verbal and written communication skills are essential. The post is available 
until 31 March 2019.

Job Ref: 005185 
  Closing Date: 23 February 2017

For full details and to apply online, please visit: 
https://recruit.liverpool.ac.uk

Dr. Svetlana Antonyuk
Senior Lecturer
Co-Director of Barkla X-ray Laboratory of Biophysics
Institute of Integrative Biology
Faculty of Health and Life Sciences
University of Liverpool
Life Sciences Building
Liverpool
L69 7ZB
--
Phone:   +44(0)151-795 5145
Email:   s.anton...@liverpool.ac.uk

http://www.biophysics.liv.ac.uk/

Re: [ccp4bb] 2 beamline development postdoctoral positions available in Hamburg: correct start date!

[Arwen Pearson]

Oops - I did in fact mean a start date of March 2017! Sorry for any 
confusion.

Thanks to the eagle-eyed Liz Duke for spotting the typo.
best wishes
arwen

On 05/12/16 16:40, Arwen Pearson wrote:
We are seeking two exceptional postdoctoral candidates to help develop 
a time-resolved endstation at the EMBL beamline P14 at PETRA III for 
ns-ms time-resolved diffraction experiments that will complement the 
faster experiments possible at the soon to be operational neighbouring 
European XFEL. The project will encompass all aspects of a 
time-resolved pump-probe X-ray diffraction experiment, including X-ray 
beam delivery, pump-probe synchronisation, sample delivery, data 
acquisition and processing. Candidates will be expected to work on 
endstation design, construction and commissioning, as well as 
supporting proof-of-principle time-resolved experiments on P14, other 
beamlines, and existing ultrafast optical spectroscopy setups. The 
successful candidates will become part of an interdisciplinary team 
from the University of Hamburg, DESY and EMBL. UNIVERSITÄT HAMBURG  
We're particularly looking for candidates who have experience of the 
development and integration of synchrotron instrumentation or 
time-resolved laser applications, as well as implementing instrument 
control.


The deadline for applications is the 23rd December 2016 for a planned 
start date in March 2018 and more details, including application 
instructions, can be found here: 
https://www.uni-hamburg.de/uhh/stellenangebote/wissenschaftliches-personal/fakultaet-mathematik-informatik-und-naturwissenschaften/23-12-16-452.pdf

[ccp4bb] 2 beamline development postdoctoral positions available in Hamburg

[Arwen Pearson]

We are seeking two exceptional postdoctoral candidates to help develop a 
time-resolved endstation at the EMBL beamline P14 at PETRA III for ns-ms 
time-resolved diffraction experiments that will complement the faster 
experiments possible at the soon to be operational neighbouring European 
XFEL. The project will encompass all aspects of a time-resolved 
pump-probe X-ray diffraction experiment, including X-ray beam delivery, 
pump-probe synchronisation, sample delivery, data acquisition and 
processing. Candidates will be expected to work on endstation design, 
construction and commissioning, as well as supporting proof-of-principle 
time-resolved experiments on P14, other beamlines, and existing 
ultrafast optical spectroscopy setups. The successful candidates will 
become part of an interdisciplinary team from the University of Hamburg, 
DESY and EMBL. UNIVERSITÄT HAMBURG  We're particularly looking for 
candidates who have experience of the development and integration of 
synchrotron instrumentation or time-resolved laser applications, as well 
as implementing instrument control.


The deadline for applications is the 23rd December 2016 for a planned 
start date in March 2018 and more details, including application 
instructions, can be found here: 
https://www.uni-hamburg.de/uhh/stellenangebote/wissenschaftliches-personal/fakultaet-mathematik-informatik-und-naturwissenschaften/23-12-16-452.pdf

[ccp4bb] 2 years Post-doc position near Paris (France)

[Marc Graille]

Post-doctoral position 
“Structural studies of post-transcriptional / translational modification 
enzymes”. 

Location: Palaiseau, Ecole Polytechnique, near Paris (30 minutes by regular 
trains), France

A 2 years post-doctoral position, funded by the ANR (French National Research 
Agency), is available at Laboratory of Biochemistry, Ecole Polytechnique-CNRS 
(France). The successful candidate will work in a young and dynamic 
international team headed by Dr Marc Graille. He/She should have a PhD in 
protein biochemistry/structural biology. Expertises in cloning, protein 
purification and X-ray crystallography are required. Experience in RNA 
production and purification as well as in protein complexes reconstitution will 
be very much appreciated.

The project aims at studying structural aspects of protein-protein and 
protein-RNA complexes involved in the post-transcriptional/translational 
modifications of eukaryotic factors involved in mRNA translation. It will be 
realized in collaboration with groups studying the role of these complexes in 
yeast or human cells.

To address these questions, the successful candidate will use a large panel of 
biochemical (protein expression and purification, enzymology, pull-down, …) and 
biophysical methods (X-ray crystallography, ITC, MALLS, fluorescence, …), which 
are all implemented in the host laboratory (Laboratory of Biochemistry, Ecole 
Polytechnique-CNRS). The lab is also equipped with a state-of-the art 
crystallization platform (Tecan and Mosquito crystallization robots plus an 
automatic system for crystallization plates imaging) and is located 2 km away 
from the French synchrotron SOLEIL, which offers regular access to protein 
crystallography beam lines (Proxima-1 and 2).
Recent publications from Dr Graille’s group related to the project:
Létoquart et al, PNAS, in press.
Figaro et al, Mol. Cell. Biol., 2012
Graille et al, Biochimie, 2012 (review)
Liger et al, Nuc. Acids Res., 2011.
van den Elzen et al; Nat. Struct. Mol. Biol, 2010
More information can be found on our website: 
http://bioc.polytechnique.fr/spip.php?rubrique117lang=en .

The Laboratory of Biochemistry has a long standing expertise in the study of 
translational apparatus and is located on the multidisciplinary “Ecole 
Polytechnique” campus, one of the most selective and prestigious French “Grande 
Ecole”, which attracts top undergraduate and graduate students worldwide. Ecole 
Polytechnique is located 25 km south from Paris and as regular train 
connections to Paris city centre (30 minutes). The campus offers all the 
equipments to perform various activities (music, theatre, …) or sports: 
swimming pools, 8 tennis courts, several football, volleyball and. basketball 
pitches, climbing walls, … 
More info on the campus can be found at : http://www.polytechnique.edu/en .

Net annual salary: around 24,500€ minimum.
Starting : 2015, depending on availability of selected candidate.
Duration: 24 months.


Applications (including CV, resume describing your relevant skills and a list 
of three references) or information requests should be sent to Marc Graille 
(marc.grai...@polytechnique.edu).
Dr Marc GRAILLE

Directeur de recherche CNRS

Team: Translation and degradation of eukaryotic mRNAs

Team supported by the ATIP-Avenir CNRS program

Laboratoire de Biochimie

ECOLE POLYTECHNIQUE - UMR7654 CNRS

91128 PALAISEAU CEDEX


Phone : +33 (0)1 69 33 48 90 – Fax : +33 (0)1 69 33 49 09


Office 033012B

Email: marc.grai...@polytechnique.edu

http://bioc.polytechnique.fr/spip.php?rubrique117

 
 

Re: [ccp4bb] 2 ligands/monomer

[Derek Logan]

Dear Wei,

The enzyme ribonucleotide reductase can, depending on organism and class, bind 
ATP as a substrate in the active site (c), as an allosteric regulator of 
substrate specificity at another site (s) and as an overall activity regulator 
at a third site (a)! It can also bind dATP at the second and third sites, but 
not as a substrate. It cannot bind to sites (c) and (s) at the same time 
although it could potentially bind to sites (s) and (a) simultaneously. Here is 
a review that you might find useful:

http://www.ncbi.nlm.nih.gov/pubmed/22050358

Best wishes
Derek

On 4 Mar 2014, at 04:48, Wei Shi wei.shi...@gmail.com wrote:

 Dear all,
 Does anyone happen to know examples of 2 ligands bind to a single protein / 
 each monomer protein in 2 different ligand binding pockets? 
 I know the following example:
 (1). phosphofructokinase, which binds ATP as both a ligand and a feedback 
 inhibitor in different sites 
 (2).  2 cAMP bound to each E. coli CAP monomer in the crystal structure. 
 
 Does any of you know other examples? Thank you so much!
 
 Best,
 Wei 

Re: [ccp4bb] 2 ligands/monomer

[Randy Read]

Hi,

Another example is the Shiga-like toxin B-subunit pentamer (i.e. the 
cell-surface binding component of this A-B toxin), which binds 3 Gb3 
trisaccharides per monomer:

http://pdbe.org/1bos
http://www.ncbi.nlm.nih.gov/pubmed/9485303

Best wishes,

Randy Read

On 4 Mar 2014, at 10:41, Derek Logan derek.lo...@biochemistry.lu.se wrote:

 Dear Wei,
 
 The enzyme ribonucleotide reductase can, depending on organism and class, 
 bind ATP as a substrate in the active site (c), as an allosteric regulator of 
 substrate specificity at another site (s) and as an overall activity 
 regulator at a third site (a)! It can also bind dATP at the second and third 
 sites, but not as a substrate. It cannot bind to sites (c) and (s) at the 
 same time although it could potentially bind to sites (s) and (a) 
 simultaneously. Here is a review that you might find useful:
 
 http://www.ncbi.nlm.nih.gov/pubmed/22050358
 
 Best wishes
 Derek
 
 On 4 Mar 2014, at 04:48, Wei Shi wei.shi...@gmail.com wrote:
 
 Dear all,
 Does anyone happen to know examples of 2 ligands bind to a single protein / 
 each monomer protein in 2 different ligand binding pockets? 
 I know the following example:
 (1). phosphofructokinase, which binds ATP as both a ligand and a feedback 
 inhibitor in different sites 
 (2).  2 cAMP bound to each E. coli CAP monomer in the crystal structure. 
 
 Does any of you know other examples? Thank you so much!
 
 Best,
 Wei 

--
Randy J. Read
Department of Haematology, University of Cambridge
Cambridge Institute for Medical Research  Tel: + 44 1223 336500
Wellcome Trust/MRC Building   Fax: + 44 1223 336827
Hills RoadE-mail: rj...@cam.ac.uk
Cambridge CB2 0XY, U.K.   www-structmed.cimr.cam.ac.uk

Re: [ccp4bb] 2 ligands/monomer

[Tim Gruene]

-BEGIN PGP SIGNED MESSAGE-
Hash: SHA1

Dear Wei,

if you are not restricted to 2 ligands, you can also look at human
serum albumin, http://pdb.org/pdb/101/motm.do?momID=37

Best regards,
Tim

On 03/04/2014 04:48 AM, Wei Shi wrote:
 Dear all, Does anyone happen to know examples of 2 ligands bind to
 a single protein / each monomer protein in 2 different ligand
 binding pockets? I know the following example: (1).
 phosphofructokinase, which binds ATP as both a ligand and a
 feedback inhibitor in different sites (2).  2 cAMP bound to each E.
 coli CAP monomer in the crystal structure.
 
 Does any of you know other examples? Thank you so much!
 
 Best, Wei
 

- -- 
- --
Dr Tim Gruene
Institut fuer anorganische Chemie
Tammannstr. 4
D-37077 Goettingen

GPG Key ID = A46BEE1A

-BEGIN PGP SIGNATURE-
Version: GnuPG v1.4.12 (GNU/Linux)
Comment: Using GnuPG with Icedove - http://www.enigmail.net/

iD8DBQFTFcxPUxlJ7aRr7hoRAmHJAKDXg9AN95L6yVNSHjpMtSyyb/aDAgCghvb+
x8f+PjbkG5hbiu8JUpTeNUo=
=CdAI
-END PGP SIGNATURE-

Re: [ccp4bb] 2 ligands/monomer

[Wei Shi]

Thank you all so much!

Best,
Wei


On Tue, Mar 4, 2014 at 7:51 AM, Tim Gruene t...@shelx.uni-ac.gwdg.de wrote:

 -BEGIN PGP SIGNED MESSAGE-
 Hash: SHA1

 Dear Wei,

 if you are not restricted to 2 ligands, you can also look at human
 serum albumin, http://pdb.org/pdb/101/motm.do?momID=37

 Best regards,
 Tim

 On 03/04/2014 04:48 AM, Wei Shi wrote:
  Dear all, Does anyone happen to know examples of 2 ligands bind to
  a single protein / each monomer protein in 2 different ligand
  binding pockets? I know the following example: (1).
  phosphofructokinase, which binds ATP as both a ligand and a
  feedback inhibitor in different sites (2).  2 cAMP bound to each E.
  coli CAP monomer in the crystal structure.
 
  Does any of you know other examples? Thank you so much!
 
  Best, Wei
 

 - --
 - --
 Dr Tim Gruene
 Institut fuer anorganische Chemie
 Tammannstr. 4
 D-37077 Goettingen

 GPG Key ID = A46BEE1A

 -BEGIN PGP SIGNATURE-
 Version: GnuPG v1.4.12 (GNU/Linux)
 Comment: Using GnuPG with Icedove - http://www.enigmail.net/

 iD8DBQFTFcxPUxlJ7aRr7hoRAmHJAKDXg9AN95L6yVNSHjpMtSyyb/aDAgCghvb+
 x8f+PjbkG5hbiu8JUpTeNUo=
 =CdAI
 -END PGP SIGNATURE-

[ccp4bb] 2 ligands/monomer

[Wei Shi]

Dear all,
Does anyone happen to know examples of 2 ligands bind to a single protein /
each monomer protein in 2 different ligand binding pockets?
I know the following example:
(1). phosphofructokinase, which binds ATP as both a ligand and a feedback
inhibitor in different sites
(2).  2 cAMP bound to each E. coli CAP monomer in the crystal structure.

Does any of you know other examples? Thank you so much!

Best,
Wei

[ccp4bb] 2 Research Associate positions at the Membrane Protein Lab, Oxfordshire

[Konstantinos Beis]

Dear All,
Two Research Associate positions have become available in the laboratory for 
crystallisation and crystallographic studies on mammalian transporter in the 
Membrane Protein Crystallography Laboratory at the Research Complex in Harwell 
(RCaH) near Didcot,  Oxfordshire. The laboratory is headed by Professor So 
Iwata,  who is a world leader in crystallisation and crystallography of 
membrane proteins. In particular,  the group has a proven track record working 
with respiratory and photosynthetic membrane protein complexes and membrane 
transporters. The laboratory is an out-house of Imperial College London and is 
fully equipped for structural studies for membrane proteins. The successful 
candidate will work on improving the crystals and solving the structure of 
these important proteins. The Biotechnology and Biological Sciences Research 
Council (BBSRC) funds the post. The duration of the posts are until 31 December 
2014.
You must have a PhD in a biological science,  or the equivalent in professional 
qualifications and experience.  You must also have experience in molecular 
cloning,  mammalian cell culturing and experience in protein crystallisation 
and crystallography. Crystallization and X-ray crystallography particularly on 
membrane proteins or macromolecular complexes,  and X-ray diffraction data 
collection are also essential.

Closing date for applications is 13 October 2013.

Our preferred method of application is online via this website:

https://www4.ad.ic.ac.uk/OA_HTML/OA.jsp?page=/oracle/apps/irc/candidateSelfService/webui/VisVacDispPGOAHP=IRC_EXT_SITE_VISITOR_APPLOASF=IRC_VIS_VAC_DISPLAYakRegionApplicationId=821transactionid=1447932834retainAM=YaddBreadCrumb=RPp_svid=42052p_spid=1633956oapc=21oas=qTAHu7O9l4komvvW1SnQCw

Best,
Kostas

Dr. Konstantinos Beis   
Lecturer
Imperial College London
Membrane Protein Lab
Research Complex at Harwell
Harwell Oxford
Didcot
Oxfordshire
OX11 0FA
UK

tel:  01235567809

url:  http://www3.imperial.ac.uk/people/konstantinos.beis

url2: http://www.diamond.ac.uk/Science/MPL/default.htm



P Please consider the environment before printing this email

[ccp4bb] 2 positions available for software developers in cryoEM

[Martyn Winn]

Dear All,

I have 2 positions available for software developers in cryoEM:

1) A developer to work alongside Chris Wood on the CCP-EM project. The post 
will support a number of software development projects (see e.g. 
http://www.ccpem.ac.uk/ccpem_projects.php), as well as providing general 
community support. 
2) A developer to work on Work Package 9 of the BioMedBridges grant 
(http://www.biomedbridges.eu/), concerned with developing a database of volumes 
with associated tools, in collaboration with developers at the EBI. 

We are looking for talented developers of scientific software. While knowledge 
of cryoEM and structural biology would be an advantage, applicants from other 
backgrounds are welcomed if you can demonstrate an ability to learn and a 
flexibility in approach. The projects are collaborative in nature, so you must 
be a good communicator and be able to work as part of a team.

The posts are located at the Research Complex at Harwell 
(http://www.rc-harwell.ac.uk/), within the group of Martyn Winn in the 
Scientific Computing Department of STFC (http://www.stfc.ac.uk/scd/), and 
alongside the core team of CCP4. The Research Complex is located on the Harwell 
Science and Innovation Campus, adjacent to the Diamond synchrotron and provides 
an exciting multi-disciplinary work environment, including many relevant 
structural biology groups.

Applications need to be made via the TopCareer site (see links on 
http://www.ccpem.ac.uk/positions.php) and informal enquiries can be made to me.

Cheers
Martyn


*
*   Dr. Martyn Winn
*   STFC Daresbury Laboratory, Daresbury, Warrington, WA4 4AD, U.K.
*   Tel: +44 1925 603455 (DL)   or   +44 1235 567865 (RcaH)
*   E-mail: martyn.w...@stfc.ac.uk   Skype: martyn.winn
*



--
Scanned by iCritical.

[ccp4bb] 2 post-doctoral positions in virus crystallography

[Pavel Plevka]

Dear all,

two post-doctoral positions are available in Pavel Plevka's group at Ceitec in 
the Czech Republic:
http://www.ceitec.eu/programs/structural-biology/x-ray-crystallography-ii/

The projects involve x-ray crystallography and cryo-electron microscopy of 
human viruses.

If you are interested, details of the jobs and how to apply can be found here:
http://www.ceitec.eu/new-position-post-doctoral-research-associate-2-positions-2/

All the best,
Pavel

[ccp4bb] 2 postdoctoral positions available@EMBL-Hamburg

[margret]

Dear All,

I would like to inform you that 2 postdoctoral positions are available 
at the EMBL Hamburg Unit in the research group of Matthias Wilmanns.
I attach brief descriptions of the Vacancy Notices below. Deadline for 
application is 15th June 2012.
Further Detailed Information can be found under : 
http://www.embl-hamburg.de/aboutus/jobs/searchjobs/index.php?newlang=1newms=srsearchregion=668


Regards
Margret Fischer
---

*Postdoctoral Positon, Reference HH_00025*
Applications are invited for research projects of the Wilmanns group in 
the EC-funded consortium SystemTB (www.systemtb.org), which aims to 
understand the pathology of /Mycobacterium tuberculosis/ during 
infection. While the core expertise of our group is in structural 
biology, we have established methods in mycobacterial genetics for the 
creation of full deletion mutants and specific point mutants using 
non-pathogenic model systems (M. smegmatis, BCG) (for examples, see: 
Noens et al. (2011) PMID: 2143903, Poulsen et al. (2010) Mol. Syst. 
Biol. PMID: 21439037). We have initialized several new collaborations 
using different --omics techniques, namely in interactomics (using 
high throughput mass spectrometry) (IBB Warsaw), metabolomics (ETH 
Zurich), proteomics (ETH Zurich), and lipidomics (CNRS Toulouse). The 
fellow is expected to carry out and to coordinate experiments in 
mycobacterial genetics in the context of ongoing and future projects. 
Most of them will be in cooperation with partners from the SystemTB 
consortium

*
Postdoctoral Positon, Reference HH_00026*
Applications are invited for research projects of the Wilmanns group 
(www.embl-hamburg.de/research/unit/wilmanns) in the new European 
consortium GoMoA with partners from Spain, France and Germany. The key 
aim of this network is to identify and to characterize protein targets 
from /Mycobacterium tuberculosis/ for lead compounds against 
tuberculosis that already have been validated by an industrial partner. 
The objective of our group is to contribute to the identification of 
protein targets, in collaboration with the group of Dr. John Overington 
from the EMBL-EBI Unit in Cambridge (UK), and on their biochemical and 
structural characterization. This novel research direction will 
complement our record in M. tuberculosis structural biology and 
functional characterization. The fellow is expected to carry out and to 
coordinate experiments in functional and subsequent structural 
characterization of protein targets from /M. tuberculos/

/
/

Re: [ccp4bb] 2

[Krystle Williams McLaughlin]

...a weight is lifted off my shoulders  
http://www.flipperkiste.de/work.link.php?jgyahooID=65l2
  

[ccp4bb] 2 senior positions at AstraZeneca

[Pauptit, Richard A]

Two senior structural biology positions available at AstraZeneca UK. One
is associate director of the crystallography/crystallization group
(recently mentioned in ccp4bb and still open) and has reference RD237,
the other is one position up and has just become available, the director
of protein structure and biophysics with reference RD300. You can find
the jobs directly with the links below, or search for the reference
numbers on www.astrazeneca.com under careers. Both should also appear in
Nature jobs at some point soon.



http://jobs.astrazeneca.com/jobs/3370-associate-director-protein-structu
re-crystallography



http://jobs.astrazeneca.com/jobs/3443-director-of-structure-and-biophysi
cs



Many thanks



Richard Pauptit

Discovery Sciences, Alderley Park

AstraZeneca UK




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for the purposes of the prevention and detection of crime, ensuring the 
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Conduct and Policies.

[ccp4bb] 2 Postdoctoral Positions - Research Complex at Harwell

[Arwen Pearson]

***
Research Officers in Dynamic Structural Science at the Research Complex 
at Harwell and the University of Bath (2 posts, fixed term for 4 years)

***

Applications are invited from suitably qualified candidates for two 
EPSRC funded four-year post doctoral Research Officer posts in Dynamic 
Structural Science.  The successful applicants will have proven track 
records in either molecular/macromolecular crystallography (post 1) or 
in XAFS techniques (post 2).  They will be housed in the Research 
Complex at Harwell, at the Rutherford Appleton Laboratory (RAL), Didcot, 
Oxfordshire, and will also be associated with the Department of 
Chemistry, at the University of Bath. 
The posts are associated with an EPSRC supported four-year project, 
centered at the new Research Complex at Harwell, to work on Dynamic 
Structural Science, using synchrotron and neutron diffraction techniques 
and/or XAFS methodologies.  The successful applicants will join a team 
of chemists and biologists from six UK Universities and from the Central 
Facilities at RAL, led by Professor Paul Raithby from the University of 
Bath. 
The main duties of the successful applicants will be to develop new 
methodologies for carrying out time resolved crystallographic and XAFS 
experiments on a range of molecular and macromolecular species.  The 
work will also include some synthesis, spectroscopic characterisation, 
computational studies and instrument development. 

The posts are available from 1st August, 2011. 


Salary:   £29,972 to £35,788
Closing Date:   Thursday 21 July 2011
Reference:  JK589
http://www.bath.ac.uk/jobs/Vacancy.aspx?ref=JK589

Informal enquiries may be addressed to Professor Paul Raithby 
(p.r.rait...@bath.ac.uk, tel. 01225 383183), however please ensure that 
applications are submitted through the University of Bath website.



--

Dr Arwen R Pearson
RCUK Academic Research Fellow
Astbury Centre for Structural Molecular Biology
Astbury Building
The University of Leeds
LS2 9JT
United Kingdom

(t) +44 (0)113 34 33032
(e) a.r.pear...@leeds.ac.uk

[ccp4bb] 2 PD and 2 PhD positions in Structural Immunology

[Gros, P.]

2 Post-doc and 2 PhD-student positions available 

in the protein crystallography group of Piet Gros, 

Bijvoet Center for Biomolecular Research,

Utrecht University, The Netherlands.

 

Structural Biology of the Complement System

 

The human complement system in blood plasma is a protein network consisting of 
~30 large multi-domain plasma proteins and cell-surface receptors. Together 
these proteins recognize and clear invading microbes and apoptotic host cells, 
linking innate and adaptive immune responses. We study the molecular mechanisms 
that underlie the biological activity of these complement proteins. Insights 
into the underlying mechanisms are instrumental to developing therapies that 
help in fighting infectious diseases, protect humans from complement-induced 
tissue damage, and possibly help to direct antibodies to clear tumor cells.

 

In recent years we have studied the central opsonization step. In this step 
the target microbe or altered host cell becomes covalently and massively 
labeled by marker molecules, which evoke various immune responses. Currently we 
are expanding our research addressing the multivalent complex formations on 
target cells that determine antibody-mediated recognition, protection of 
healthy host cells against clearance, stimulation of B-cells and clearance by 
macrophages. This work involves predominantly mammalian protein expression, 
crystal-structure determination of large protein complexes, electron microscopy 
(in coll. with Bram Koster, Leiden University) and single-molecule fluorescence 
(in coll. with Hans Gerritsen, Utrecht University).

 

Relevant key publications from our group:

-Structures of complement component C3 provide insights in function and 
evolution of immunity, B.J.C. Janssen, E.G. Huizinga, H.C.A. Raaijmakers, A. 
Roos, M.R. Daha, K. Nilsson-Ekdahl, B. Nilsson and P. Gros, Nature 437, 505-511 
(2005). 

-Structure of C3b reveals conformational changes underlying complement 
activity, B.J.C. Janssen, A. Christodoulidou, A. McCarthy, J.D. Lambris and P. 
Gros, Nature 444, 213-216 (2006). 

-Factor B structure provides insights into the activation of the 
central protease of the complement system, F.J. Milder, L. Gomes, A. Schouten, 
B.J.C. Janssen, E.G. Huizinga, R.A. Romijn, W. Hemrika, A. Roos, M.R. Daha and 
P. Gros, Nature Structural and Molecular Biology 14, 224-228 (2007). 

-Structure of C8a-MACPF reveals mechanism of membrane attack in 
complement immune defense, M.A. Hadders, D.X. Beringer and P. Gros, Science 
317, 1552-1554 (2007). 

-Complement driven by conformational changes, P. Gros, F.J. Milder and 
B.J.C. Janssen, Nature Reviews Immunology 8, 48-58 (2008).

-Structural and functional implications of the alternative complement 
pathway C3 convertase stabilized by a staphylococcal inhibitor, S.H.M. 
Rooijakkers*, J. Wu*, M. Ruyken, R. van Domselaar, K.L. Planken, A. Tzekou, D. 
Ricklin, J.D. Lambris, B.J.C. Janssen, J.A.G. van Strijp and P. Gros, Nature 
Immunology doi:10.1038/ni.1756 (2009). *These authors contributed equally.

-Structure of complement fragment C3b-factor H and implications for 
host protection by complement regulators, J. Wu, Y.-Q. Wu, D. Ricklin, B.J.C. 
Janssen, J.D. Lambris and P. Gros, Nature Immunology doi:10.1038/ni.1755 (2009).

 

The selected candidates will work in a small team focused on the complement 
system. The post-docs will focus on reconstitution of large complexes (up to 
MDa scale) on membrane surfaces, determine crystal structures and collaborate 
with outside groups on EM and smFRET. The PhD students will focus predominantly 
on expression of mammalian proteins and crystal-structure determinations of 
protein complexes. Candidates with prior experience in structural biology or 
biophysics are preferred.

 

Our group is part of the laboratory of Crystal and Structural Chemistry of the 
Bijvoet Center. We house a facility for mammalian protein expression and 
purification. We are fully equipped for crystallographic studies. Other groups 
in the Bijvoet Center include mass spectrometry/proteomics (Heck), NMR (Boelens 
and Baldus), modeling of protein complexes (Bonvin), membrane enzymology (Van 
Meer), chemical biology (Killian and Liskamp) and protein folding (Braakman). 
Together with the center for Utrecht Life Science (Medical sciences, Veterinary 
sciences, Biology, Pharmacy of the Utrecht University and the Hubrecht 
laboratory for developmental biology) the Bijvoet Center forms a strong and 
stimulating scientific environment.

 


Terms of employment


 


Post-doc positions: we offer a position 2 and for 3 years, full time (1 fte). 
Your performance will be evaluated before 1 year to decide on (intended) 
prolongation of the contract. 


Your salary, depending on experience and performance, amounts EUR 2,379 to 
maximally 

EUR 3,755 (salary scale 10) gross per month. 

 


PhD student positions: we offer positions 

[ccp4bb] 2 Papers required

[Exec]

I am searching for the following two papers. i will be grateful if anyone 
can help me with the link or full text of these paper

J Pharm Biomed Anal. 1995 Jan;13(1):9-20. 
In vitro bioassay with enhanced sensitivity for human granulocyte colony-
stimulating factor.Hammerling U, Kroon R, Sjödin L.

http://www.ncbi.nlm.nih.gov/pubmed/7536474

1: J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Apr 15;866(1-2):133-
53. Epub 2008 Feb 5. Links
Liquid chromatography of recombinant proteins and protein drugs.Geng X, 
Wang L.

http://www.ncbi.nlm.nih.gov/pubmed/18294930

thanks in anticipation

[ccp4bb] 2 postdoc positions at Cornell Oregon State

[Donnie Berkholz]

TWO POSTDOCTORAL POSITIONS
Cornell University and Oregon State University

As seen in the 09 May issue of Science

Two Postdoctoral positions are available as part of a collaborative
project between Cornell University and Oregon State University to
undertake a structure/function analysis of merlin, the product of the
NF2 tumor suppressor gene.

One position will investigate the biochemistry and cell biology of
merlin and structure-based mutants. The successful candidate will have
a Ph.D. and/or M.D. and a strong background in molecular cell biology.
Applicants should send curriculum vitae, a brief description of
research accomplishments, and arrange for three letters of
recommendation to be sent electronically to: Dr. Anthony Bretscher,
Weill Institute for Cell and Molecular Biology, Cornell University,
Ithaca, New York. E-mail: [EMAIL PROTECTED] For full
consideration, apply by May 31, 2008.

The second position will exploit X-ray crystallography in the study of
merlin and its mutants. The successful candidate will have a Ph.D. in
biochemistry and biophysics or other relevant science, experience in
protein expression and purification, and protein crystallography.
Preferred qualifications include a demonstrable commitment to promoting
and enhancing diversity. Applicants should submit curriculum vitae and
a brief description of research accomplishments. Inquiries about the
position and three letters of recommendation should be addressed to Dr.
P. Andrew Karplus at e-mail: [EMAIL PROTECTED] To view
the full position announcement and to apply online visit website:
http://oregonstate.edu/jobs, posting #0002516. For full consideration,
apply by May 31, 2008.

Cornell University is an Affirmative Action/Equal Opportunity Employer
and Educator. Oregon State University is an Affirmative Action Equal
Opportunity Employer and has a policy of being responsive to
dual-career needs.

[ccp4bb] 2 Postdoc positions in Dundee

[Alice Dawson]

University of Dundee, College of Life Sciences

Division of Biological Chemistry and Drug Discovery

Enthusiastic and highly motivated individuals are sought to study key  
enzymes of microbial pathogens. In particular to advance fundamental  
understanding of biosynthesis and inhibition of trypanothione and  
glycosylphosphatidylinositol anchor assembly and biosynthesis in  
trypanosomatid parasites. The positions are funded by a Wellcome  
Trust programme grant and to be held in a world-class  
interdisciplinary centre.


 POSTDOCTORAL RESEARCH ASSISTANTS (2 POSTS)

GRADE 7 (£26,666 - £32,796)

Postdoctoral Research Assistants are required to characterise the  
structure-function relationships of important biosynthetic enzymes  
essential in trypanosomatid parasites. Applicants are expected to  
have experience in protein crystallography or molecular biology,  
biochemistry or chemical crystallography. Experience in production of  
proteins in eukaryotic systems would be particularly welcome.


Please quote ref:  LS/1906

All posts are available for two years in the first instance. The  
level of appointment is flexible and will depend on experience and  
track record. For postdoctoral positions applicants are expected to  
have, or to obtain shortly, a PhD in a relevant subject.  Training,  
as required will be provided in a supportive environment enabling  
researchers to extend their skills and expertise.  Career progression  
is important and staff will be encouraged to participate in a wide  
range of research, and in this the ability to work well in a team  
will be critical.


The successful candidates will benefit from access to cutting edge  
facilities in crystallography, biochemistry, cell biology, synthetic  
and medicinal chemistry, parasitology, drug discovery, proteomic and  
other core facilities. In addition to joining the Scottish Structural  
Proteomics Facility, a highly successful cooperative with The  
University of St. Andrews.


Informal enquiries may be made to Prof Bill Hunter, tel:  
(01383-385745 or e-mail: [EMAIL PROTECTED] (Please do not send  
applications to this email address).


A few facts about The College of Life Sciences at Dundee:



The College of Life Sciences has over 720 research and support staff  
from 53 countries and an annual research turnover in excess of  
£20 million.
According to Thompson Scientific of Philadelphia, based on citations  
per paper over the last 10 years, Dundee is the top University in  
Europe in ‘Biology and Biochemistry’ and 2nd in Europe in ‘Molecular  
Biology and Genetics’.
Dundee has twice been named ‘the best place to work in Europe’ in a  
poll of scientists conducted by The Scientist magazine.
The College of Life Sciences has been consistently rated ‘5- 
star’ (the highest rating) by the UK national Research Assessment  
Exercise.



In addition to an excellent scientific environment Tayside offers an  
affordable standard of living in an area of outstanding natural  
beauty situated beside the sea and the highlands of Scotland.


Applications in the form of a CV and covering letter (2 copies of  
each), including the names and addresses of 3 referees, should be  
sent to Human Resources, College of Life Sciences, JBC/MSI/WTB  
Complex, University of Dundee, DD1 5EH, (HR- 
[EMAIL PROTECTED]) quoting the appropriate reference number.


Applicants will only be contacted if invited for interview.

Closing date:  7 December 2007

The University of Dundee is committed to equal opportunities and  
welcomes applications from all sections of the community.


www.jobs.dundee.ac.uk

++

W. N. Hunter
Professor of Structural Biology, FRSE
Div. of Biological Chemistry  Drug Discovery
College of Life Sciences
Univ. of Dundee
Dundee
DD1 5EH
ph: (0)1382-385745

[ccp4bb] 2 postdoctoral positions at KI Stockholm

[Andreas Kohl]

Dear all,

we have currently two open postdoctoral positions in our department. We
would very much appreciate it if you could bring this announcement to
the attention of suitable candidates.
All inquiries and applications should be send to:

Prof. Pär Nordlund ([EMAIL PROTECTED]) or Dr. Said Eshaghi
([EMAIL PROTECTED])

Andreas




Postdoctoral positions available at Karolinska Institutet, Sweden

Two postdoctoral positions are available at the division of Biophysics
in the department of Medical Biochemistry and Biophysics, at Karolinska
Intitutet in Stockholm. The division is headed by Professor Pär Nordlund
and is focused on functional characterization of proteins, primarily
using X-ray crystallography. In addition, new technologies are being
developed and improved as tools to enable high-throughput approaches
within protein production. The group has a strong record in structure
determination of soluble and membrane proteins. The laboratory is
well-equipped with state-of-the-art instruments for protein production
and crystallization.

Currently, two postdoctoral positions are available in the membrane
protein group, working with medically important proteins from different
families, such as solute transporters, ion channels and enzymes:
1. Membrane protein chemistry/structural biology. The applicant should
have strong background in recombinant membrane protein production in E.
coli system, preferably with some experience in protein crystallization.
The main topic is to develop new and improved methods for purification
and crystallization of integral membrane proteins. Knowledge about X-ray
crystallography is ideal but not a requirement. The successful candidate
will be part of a dynamic team that is working on production,
crystallization and structure determination of membrane proteins. The
applicant must therefore have the ability to work as a team-player as
well as independently. The position is initially announced for two years.
2. Membrane protein X-ray crystallography. The applicant should have a
strong background in X-ray crystallography with a good track record. The
main tasks are crystallization screening, crystal optimization, data
collection and structure determination of integral membrane proteins.
Previous experience with membrane proteins is ideal but not a
requirement. The successful candidate will be part of a team that is
working on production and crystallization of membrane proteins. The
applicant must therefore have the ability to work as a team-player as
well as independently. The position is initially announced for two years.

Applicants should send a full CV, including a publication list, together
with the name and contact details of three references to:

Prof. Pär Nordlund ([EMAIL PROTECTED]) or Dr. Said Eshaghi
([EMAIL PROTECTED])

---
Prof. Pär Nordlund

[EMAIL PROTECTED]
Institutionen för Medicinsk Biokemi och Biofysik (MBB)
Karolinska Institutet, 171 77 Stockholm
Biofysik