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I'm currently working with a glycoprotein and am having great difficulty 
deglycosylating it for crystallisation. I can completely remove the sugars very 
easily when the protein is denatured (not much good when you're wanting to 
crystalise it), but seems completely resistant to treatment with endo H or 
pngase F when done under native conditions. Any hints on getting this to work 
would be greatly appreciated. 

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Dr Paul A. McEwan
Protein Crystallography Group
Centre for Biomolecular Science
Clifton Boulevard
University of Nottingham
Nottingham
NG7 2RD
Tel: 0115 8468009
http://www.nottingham.ac.uk/~pazxtal
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