Thank you so much, Leanne.  This information is that to which I alluded
(but eluded me when I sought it. <G>)

You know, breeders go through a lot of grief when they lose a puppy in
whelping.  And, not that one can easily compare grief to grief, but I
found it so much harder to spend the night wondering if our champion
ruby girl would make it out of the ICU with her pyometra.  In the
instance of a newborn pup, it is a sharp disappointing pain and one
always wonders if one could have done something just a bit differently
to save it.  But when it is an almost three year old beloved pet/show
bitch into whom one has put hopes, dreams, training, effort, love,
attention, the fear/grief is just terrible.

It is not at all unlike any pet who is diagnosed with a serious illness.

What I wonder....and perhaps there are some studies on this as
well.....is whether short cycling is an indicator of pending
pyometritis?  I know that in horses we would worry about such heat
cycling.  I'm thinking that while I follow the heart protocol should I
see short cycling again I would be most tempted to breed a bitch with
longevity and heart clear dogs behind her as soon as possible.

Thanks again,

Suze



Leanne Bertani wrote:

> The reproductive issue is a sticky wicket.  Certainly if all I wanted to do
> was protect fertility and be certain a cavalier maintained uterine health, I
> would breed early and often, and spay at about age 4.  In beagle colony
> studies (Exp Anml July 01) 15% of beagles greater than 4 years of age
> developed pyometra.
>
> But there is also the argument that pyometra has a genetic predisposition,
> and that by spaying early, we don't know which lines are more likely to
> develop pyometra.  (This was mentioned privately by one of the geneticists.)
> There are studies in horses to suggest that certain genetic haplotypes tend
> to be protective, and certain genetic haploytypes tend to make the horse
> more susceptible to endometritis.(Pemberton AD, John HA, Ricketts SW,
> Rossdale PD, Scott AM. Investigation of association between alpha-1
> proteinase inhibitor haplotype and endometritis in the thoroughbred mare.
> (Equine Vet J. 1994 Mar;26(2):122-4.)
>
> For those of us who love our dogs, waiting to see who might develop
> pyometritis could be considered to be risky.  Mortality may range between
> 5-10%, higher if it goes unrecognized for any length of time, and some
> studies, between 25-50% of the intact cavalier bitches develop it in their
> lifetime.  In Sweden, studies (data on over 200,000 dogs) showed that more
> than 20% of intact bitches (all breeds) will develop pyometritis by age 10.
> Cavaliers were a particularly high risk breed (along with Collies, Rotts,
> Goldens, Eng Cockers) with rates up to 54%.    (J Vet Intern Med 2001
> Nov-Dec;15(6):530-8 Breed risk of pyometra in insured dogs in
> Sweden.Egenvall A, Hagman R, Bonnett BN, Hedhammar A, Olson P, Lagerstedt
> AS.)
>
> The large incidence in particular breeds supports the suggestion of a
> genetic predisposition.  Besides the genetic predisposition, there are risk
> factors for pyometra, such as skipping breeding cycles.  From Tilley and
> Smith, DVMs Veterinary Consult; ref Hardy, RM, Osborne, CA, Canine Pyometra:
> pathophysiology, disagnosis and treatment...J Am Anim Hosp Assoc:
>
> "Repeated exposure of the endometrium to high concentrations of estrogen
> followed by high concentrations of progesterone in the absence of pregnancy
> leads to cystic endometrial hyperplasia." and  "Pyometra develops secondary
> to cystic endometrial hyperplasia when bacterial invasion of the abnormal
> endometrium leads to an intraluminal accumulation of purulent exudate."
>
> I don't know how to resolve the issues.  I might be tempted to use a little
> younger bitch with a much older heart clear dog, if I could find a good
> match.  For now, I'll just throw out the available info in hopes that it
> helps some of you make your breeding decisions.
>
> Leanne
>
>
> ---Original Message---
> Read my earlier post about reproductive issues.
> Best,
> Suze
>
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--
Suze at Llawen Cavaliers
"...I have seen that in any great undertaking it is not enough for a man
to depend simply upon himself."  -Isna Ia-wica
"Thought comes before speech" Luther Standing Bear

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