On Friday, April 19, 2013 9:59:34 AM UTC-4, Bruno Marchal wrote:
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> On 18 Apr 2013, at 22:05, Craig Weinberg wrote:
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> On Thursday, April 18, 2013 1:29:29 PM UTC-4, Brent wrote:
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>>  On 4/18/2013 8:15 AM, John Clark wrote:
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>> On Wed, Apr 17, 2013  meekerdb <[email protected]> wrote:
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>>  > It's been proposed that the susceptibility to mutation is itself a 
>>> characteristic subject to natural selection.
>>>
>>
>> If a animal is undergoing stress (too hot, too cold, too thirsty, too 
>> hungry whatever) that means there is something about it that is not well 
>> adapted to its environment; I can imagine a gene that in times of stress 
>> would switch on and produce a chemical that increases the rate of random 
>> mutation in the genes of the offspring of that stressed animal. Most of the 
>> offspring would have mutated in the wrong direction and die but they would 
>> have probably died anyway because they would have been as poorly adapted as 
>> there parent was, but if the mutational effect was not too strong (even if 
>> it's in the right direction you can change things too far) it could 
>> increase the likelihood that at least one of its children would be better 
>> adapted than its parent. However I maintain that such a stress induced 
>> mutation producing gene has had no significant effect on the history of 
>> life, at least not in animals that reproduce sexually.   
>>  
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>> That's a kind of Lamarckian adjustment of mutability.  What I was 
>> referring to is simple Darwinian adjustment of mutability.  There are error 
>> correcting mechanisms for DNA reproduction.  Suppose they worked perfectly: 
>> then there would never be any genetic variation and when the evironment 
>> changed the species would go extinct.  But if they had a slight error rate 
>> then there would develop a range of genetic diversity that might, under 
>> environmental change, result in survivors or even new species.  So on 
>> strictly Darwinian theory the DNA error correction may be selected to be 
>> less than perfect.
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> How does a deterministic universe invent something which is intentionally 
> less than perfect? I'm not saying that it couldn't, or didn't, but why 
> would there really even be any possibility of volatility built into physics 
> in the first place? What, in a deterministic universe, constitutes an 
> 'error'?
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> A deterministic reality might be unable to make an error at the "bottom 
> level", but if it can emulate high level complex processes, like running 
> some complex software, and such software can make an error with respect to 
> the goal (like "survive"). Look at some youtube "crash investigation" 
> showing why today some plane crash are due to computer errors. The error 
> can have multiple origin, hardware or software.
> Likewise it is reasonable for a biologist to say that when a DNA 
> polymerase introduces an unwanted supplementary nucleotide, it is making an 
> error. In fact living cells contains a lot of error correction code to 
> handle such cases, with 'error' taken in a sense similar to the one used in 
> computer science.  This illustrates that some errorless low-level can 
> support higher level errors.
>
> Bruno
>

It seems like you are bringing in empirical evidence of errors in the real 
world and using that to justify the expectation that at some point between 
low-level and high-level, this 'error' potential emerges as a condition of 
complexity.

What I am asking for though is precisely that this point be explained by 
theory. What is the theory of the emergence of the first error?

Craig
 

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> Craig
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>> Brent
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>>  
>> Such a stress-mutation gene has never been found in a sexual animal and 
>> it's easy to see why. In sex all the genes are not inherited in one big 
>> package but are shuffled around with the genes of the other parent, so a 
>> animal that was lucky enough to inherit the good genes produced by the 
>> hypothetical stress-mutation gene but not the stress-mutation gene itself 
>> would do just as well or better than a animal that got both the good genes 
>> and the stress-mutation gene that is no longer active because the animal is 
>> no longer under stress. So even if such a stress-mutation gene did occur in 
>> one individual in a population it would vanish in just a few generations 
>> from the gene pool. Natural Selection doesn't figure  "I better keep that 
>> stress-mutation gene because even though there is no stress now that could 
>> change and such a gene might come in handy in the future".  Evolution has 
>> no foresight and can't think and all that matters to it is what's happening 
>> right here right now.  
>>
>>   John K Clark 
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>>  
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