[ccp4bb] PhD studentship available at Newcastle and Monash University, Australia - fully funded (UK only)

[Paula Salgado]

Dear colleagues
I’ve got a fully funded PhD studentship (UK only) in my lab and in 
collaboration with Prof Dena Lyras at Monash University, and I’m reaching out 
to ask for your help in spreading the word.
It's focused on S-layers variants and is a multidisciplinary project, with 2 
years at Newcastle University and 1 year at Monash University, Australia. Full 
stipend at NU and extra funds to support travel and accommodation in Australia 
(for UK/EU settled status students only).
https://www.findaphd.com/phds/project/phd-studentship-in-structural-microbiology-c-difficile-s-layer-variation-from-structure-to-role-in-disease/?p172314
It includes structural biology (crystallography, cryoEM/ET), biochemistry, 
microbiology (at NU) and infection models (at Monash) so will suit a wide range 
of backgrounds. Anyone with good lab competency, enthusiastic and willing to 
learn is welcome, with no particular restrictions of background and 
biological/structural topics, including chemistry would be suitable.
If you know any good students who might be interested, please encourage them to 
apply or get in touch with me directly. Deadline is July 1st
Thanks a lot for your help!
Paula



===

Professor Paula S. Salgado
Chair of Structural Microbiology


Due to my own work/life balance, my reply might be delayed and you might get 
emails outside your normal working hours. In any case, I do not expect a 
response outside those hours. Stay safe.


Newcastle University Biosciences Institute
Faculty of Medical Sciences
2nd Floor Cookson Building
Newcastle University
Newcastle upon Tyne, NE2 4HH, UK

Tel: +44 (0)191 208 7432
Email: paula.salg...@ncl.ac.uk





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[ccp4bb] PhD studentship - Structural and Computational Studies of transcription factor interactions in Multiple Myeloma - University of Sussex

[Erika Mancini]

Dear all,

We are seeking a motivated and experienced PhD student to join our team in the 
Department of Biochemistry at the University of Sussex. The studentship will 
focus on the structural and functional characterization of transcription 
factors involved in Multiple Myeloma.

The student will use a combination of biochemical, biophysical, and structural 
biology techniques to study the interaction between proteins and DNA. The 
student will also use computational modelling to study the impact of DNA 
interactions on the expression of target genes.

The successful candidate will have a strong background in molecular biology and 
biochemistry and experience in protein expression and purification is 
essential. Experience in structural biology and computational modelling is 
desirable but not necessary. The student will be able to work independently and 
as part of a team. This is a collaboration between the Department of 
Biochemistry (Dr Erika Mancini) and the Brighton and Sussex Medical School (Dr 
Simon Mitchell) at the University of Sussex.


The application deadline is Friday 28th April 2023 for a starting date in 
October 2023.

If you have any questions about the project, don't hesitate to contact myself 
at erika.manc...@sussex.ac.uk

Kind regards
Erika

[cidimage001.png@01D85B27.CB477660]



Dr Erika Mancini PhD

Associate Professor in Biomedical Structural Biology

Director of Research Staff Development

Office 3C18b, JMS Building

School of Life Sciences

University of Sussex
Falmer, Brighton, BN1 9QG



Tel: +44 (0)1273 877681

Email I Staff 
profileI Lab 
website I 
Twitter I 
ORCID I 
LinkedIn




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[ccp4bb] PhD studentship to study innate immune proteins by X-ray crystallography and croEM in collaboration with Keele University and Diamond Light Source

[Mikolajek, Halina (DLSLtd,RAL,LSCI)]

Dear all,

We have an exciting collaborative PhD studentship project between Keele 
University (Dr Annette Shrive) and Diamond Light Source (Dr Halina Mikolajek 
and Dr David Owen), the UK’s national synchrotron science facility located at 
the Harwell Science and Innovation Campus. The project will use a variety of 
techniques in structural biology, including X-ray crystallography and 
cryo-electron microscopy (cryoEM), at both Keele and Harwell to characterise 
structurally the interactions and effector mechanisms of the innate immune 
proteins, human C-reactive protein (CRP) and complement component C1q. The 
innate immune molecule CRP and the complement system play key roles in 
infection and inflammation. There is much biological and medical interest in 
their role including how they relate to inflammatory processes including 
cardiovascular and autoimmune diseases.

The student will spend half of their time at Keele University and time at 
Diamond Light Source.

To read further details and apply, see the advert here:
https://www.diamond.ac.uk/Careers/Students/Studentships/2023-projects/2023-STU0473.html
 under the title Structural insight into human C-reactive protein effector 
mechanisms [STU0473]

The application deadline is 14th April 2023 for a starting date in October 2023.

If you have any questions about the project, don't hesitate to contact either 
myself: halina.mikola...@diamond.ac.uk or Dr Annette Shrive at: 
a.k.shr...@keele.ac.uk.

Kind regards
Halina

Dr Halina Mikolajek
Research Scientist at VMXi and Crystallisation Facility Manager
Diamond Light Source
Harwell Science and Innovation Campus
Didcot
OX11 0DE
UK

halina.mikola...@diamond.ac.uk


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are not the intended addressee or an authorised recipient of the addressee 
please notify us of receipt by returning the e-mail and do not use, copy, 
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Any opinions expressed within this e-mail are those of the individual and not 
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Diamond Light Source Ltd. cannot guarantee that this e-mail or any attachments 
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Diamond Light Source Limited (company no. 4375679). Registered in England and 
Wales with its registered office at Diamond House, Harwell Science and 
Innovation Campus, Didcot, Oxfordshire, OX11 0DE, United Kingdom




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[ccp4bb] PhD studentship in physics and structural biology of protein self-assembly at the University of Edinburgh

[Owen Davies]

Dear colleagues,

I would like to advertise an EPSRC-funded studentship that is available in my 
lab at the University of Edinburgh:

"The physics and structural biology of supramolecular protein self-assembly in 
meiotic chromosome synapsis"

One of the largest protein structures in the cell is the synaptonemal complex 
(SC), which synapses together homologous chromosomes to facilitate their 
recombination during meiosis. This project aims to uncover the physics of how 
the SC is formed through self-assembly of its protein components. This will 
involve a wide range of biochemical, biophysical, structural biology, 
computational and theoretical modelling methods. The laboratory-based methods 
include recombinant protein expression and purification, light and X-ray 
scattering, X-ray crystallography, cryo-EM and cryo-ET, which will include data 
collection at the Diamond Light Source synchrotron facility 
(www.diamond.ac.uk).
 Computational and theoretical methods include AI-based structural modelling, 
molecular dynamics, and building and simulating mathematical models of 
bio-assemblies, which will be performed in collaboration with the Institute for 
Condensed Matter and Complex Systems 
(https://www.ph.ed.ac.uk/icmcs).

This PhD provides an excellent opportunity for a student with a 
biochemical/structural biology, computational or physics background to engage 
in cutting-edge research into the physics of life.

For more information, please see:

https://www.findaphd.com/phds/project/the-physics-and-structural-biology-of-supramolecular-protein-self-assembly-in-meiotic-chromosome-synapsis/?p156057

To apply, please follow the 'institution website' link at the above address and 
complete the application form.

Application deadline: 31st March

Best wishes,

Owen.

Dr Owen Davies
Wellcome Senior Research Fellow
Institute of Cell Biology
University of Edinburgh
Michael Swann Building
Max Born Crescent
Edinburgh EH9 3BF
United Kingdom
The University of Edinburgh is a charitable body, registered in Scotland, with 
registration number SC005336. Is e buidheann carthannais a th' ann an Oilthigh 
Dh?n ?ideann, cl?raichte an Alba, ?ireamh cl?raidh SC005336.



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[ccp4bb] PhD studentship at the University of Konstanz

[Olga Mayans]

*PhD studentship at the University of Konstanz*
 
We have a vacancy for a PhD student to join our laboratory at the Department of 
Biology, University of Konstanz, Germany. 

Our laboratory studies the molecular mechanisms underpinning the stress 
response, adaptation and disease process of striated muscle. The focus of the 
available PhD project is on identifying and characterizing protein complexes 
that mediate the communication of the contractile sarcomere with other cellular 
organelles, in particular the nucleus, thereby regulating the gene expression 
programme and adaptive metabolism of the myofibril in function of mechanical 
activity. Mechanistic hypotheses are to be developed and tested at the 
molecular level. We apply an integrative approach to structural biology that 
combines a rich variety of biochemical, biophysical, computational and 
structural methodologies, with emphasis on X-ray crystallography. 

*Qualifications*
Applicants should hold (or be in the process of obtaining) a Master's degree in 
biochemistry or related discipline, and be interested in learning both 
laboratory-based and computational methods as applicable to the study of 
biomolecules. A strong motivation to understand and discover the molecular 
mechanisms that enable function in living cells is required. Preliminary 
experience in cloning and recombinant protein production is expected. Good 
command of written and spoken English, the ability to work in a team, and good 
communication and organizational skills are required. 

*Application* 
Applications should contain the following documents in PDF format: 
1. Applicant's CV
2. Copies of original degree transcripts displaying marks obtained
2. A statement of motivation for pursuing PhD studies in molecular sciences 
3. Contact details of two referees
 
Informal enquiries and application materials should be submitted by email to: 
olga.may...@uni-konstanz.de

The position is fully-funded. The starting date is flexible, but a prompt start 
is desirable. 


Prof. Olga Mayans
Biophysics and Structural Biology
Department of Biology
Universität Konstanz
D-78457 Konstanz, 
Germany 




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[ccp4bb] PhD studentship in the pioneering use of bovine knob domains for an antibody-assisted structure-based drug discovery approach targeting proteins involved in chronic inflammatory diseases

[Hall, Gareth A.F. (Dr.)]

Dear all,

There is a PhD studentship available in my lab at the Leicester Institute of 
Structural and Chemical Biology, University of Leicester, in partnership with 
the biopharmaceutical company, UCB. This position would be to start in October 
2023

We will use an innovative antibody-assisted drug discovery approach to target 
key drivers of chronic inflammatory conditions. This will involve the 
generation of high affinity antibodies and nanobodies against fully validated 
inflammatory drug targets to allow for the identification, characterisation, 
and exploitation of new opportunities for drug discovery. This project would be 
an opportunity to further capitalise on the expertise developed within the 
research group and allow us to investigate the use of knob domains, found in 
bovine antibodies, as an alternative to single chain antibodies, to understand 
how these smaller modalities access different epitopes and improve the 
probability of obtaining structural data to facilitate the identification of 
functional, small molecule hits.

Protein crystal structures will be obtained for a selected portfolio of 
nanobodies bound to target proteins, which will provide an essential foundation 
for both structure-based design and fragment-based screening approaches to 
obtain small molecule modulators of activity, providing a novel, potentially 
more effective route to develop small molecule therapeutics.

The project will also provide thorough research training in many aspects of 
protein science, structural biology and functional assays, together with the 
opportunity for the PhD student to spend an extended period (3-6 months) 
working at the UCB site in Slough.

Full details are available at: 
https://le.ac.uk/study/research-degrees/funded-opportunities/future-50-ri.

The application deadline is 20th of January 2023. Please contact Dr Gareth 
Hall: gh...@leicester.ac.uk or Dr Cyril 
Dominguez: cd...@leicester.ac.uk for further 
informal details.

Thanks,

Gareth



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[ccp4bb] PHD studentship in inhibitor/fragment binding crystallography with cancer target proteins at room temperature

[Hough, Michael (DLSLtd,RAL,LSCI)]

Dear all,

There is a PhD studentship opportunity at the Institute of Cancer research, 
London in partnership with Diamond. This would be to start in October 2023

This project is to explore the binding of inhibitors and fragments to the 
cancer drug target proteins BCL6 and HSP70 using multicrystal data measured at 
the room temperature in situ beamline VMXi at Diamond. You will compare this 
room temperature data with corresponding cryogenic data of the same complexes. 
You will also have the opportunity to investigate the influence of X-ray 
radiation damage to bound ligands containing heavier atoms such as halogens and 
the influence this has on binding modes. The knowledge gained will be broadly 
applicable to drug design methods as well as providing specific advances in 
drug discovery for these two important cancer targets.

The project offers the chance to work at one of the world's leading drug 
discovery centres at the ICR and in close partnership with the U.K.'s national 
synchrotron facility at Diamond.

Full details are available here: 
https://www.icr.ac.uk/studying-and-training/phds-for-science-graduates/phd-studentship-projects
 under the project title Exploring the differences in the structural 
characterisation of inhibitor binding between cryo- and room-temperature using 
multicrystal X-ray crystallography

the application deadline is 13th of November 2022. for informal queries please 
contact Dr Rob van Montford : 
rob.vanmontf...@icr.ac.uk or myself at:  
michael.ho...@diamond.ac.uk

Thanks,

Mike

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This e-mail and any attachments may contain confidential, copyright and or 
privileged material, and are for the use of the intended addressee only. If you 
are not the intended addressee or an authorised recipient of the addressee 
please notify us of receipt by returning the e-mail and do not use, copy, 
retain, distribute or disclose the information in or attached to the e-mail.
Any opinions expressed within this e-mail are those of the individual and not 
necessarily of Diamond Light Source Ltd. 
Diamond Light Source Ltd. cannot guarantee that this e-mail or any attachments 
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may sustain as a result of software viruses which may be transmitted in or with 
the message.
Diamond Light Source Limited (company no. 4375679). Registered in England and 
Wales with its registered office at Diamond House, Harwell Science and 
Innovation Campus, Didcot, Oxfordshire, OX11 0DE, United Kingdom




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[ccp4bb] PhD studentship in time resolved crystallography of multifunctional enzymes using synchrotron and XFEL facilities

[Hough, Michael (DLSLtd,RAL,LSCI)]

Dear all,

We have extended the deadline for the studentship and will now consider 
applications as they are received with no fixed closing dates. I will be very 
grateful if you could pass this on to any potentially interested candidates.





We have a fully funded four year PhD studentship available from October 2022, 
as a joint project between Diamond Light Source (Mike Hough and Robin Owen) and 
the University of Essex (Jonathan Worrall).

The project will involve the application of time resolved crystallography to 
study enzyme reactions and mechanisms in multifunctional heme enzymes. 
Reactions will be followed in crystals using spectroscopic approaches to 
identify appropriate time points and monitor reactions. There will be extensive 
opportunities to use XFEL and synchrotron serial crystallography beamlines and 
to carry out complementary biochemical and spectroscopic work. Work at Diamond 
will primarily be at beamlines VMXi and I24 with around two years of the 
project being based at Diamond. We have an ongoing collaboration with the SACLA 
XFEL and conduct regular experiments there, with other XFEL sources potentially 
be used as required for the project.

Details are available here: 
https://www.diamond.ac.uk/Careers/Students/Studentships/2022-projects/2022-STU0436.html
 where you can also find application details. There is no fixed closing dates 
although shortlisting and interviews will be carried out when suitable 
candidates have been identified.

I'd be grateful if BB members could pass this onto any potentially interested 
candidates and/or advertise locally

Informal enquiries can come to me 
(michael.ho...@diamond.ac.uk), or to either 
Robin Owen (robin.o...@diamond.ac.uk) or 
Jonathan Worrall (jworr...@essex.ac.uk).




Prof Mike Hough

Principal Beamline Scientist - VMXi
Diamond Light Source Ltd
Harwell Science and Innovation Campus



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are not the intended addressee or an authorised recipient of the addressee 
please notify us of receipt by returning the e-mail and do not use, copy, 
retain, distribute or disclose the information in or attached to the e-mail.
Any opinions expressed within this e-mail are those of the individual and not 
necessarily of Diamond Light Source Ltd. 
Diamond Light Source Ltd. cannot guarantee that this e-mail or any attachments 
are free from viruses and we cannot accept liability for any damage which you 
may sustain as a result of software viruses which may be transmitted in or with 
the message.
Diamond Light Source Limited (company no. 4375679). Registered in England and 
Wales with its registered office at Diamond House, Harwell Science and 
Innovation Campus, Didcot, Oxfordshire, OX11 0DE, United Kingdom




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[ccp4bb] PhD studentship in time resolved crystallography of multifunctional heme enzymes

[Hough, Michael (DLSLtd,RAL,LSCI)]

Hi all,

We have a four year PhD studentship available from October 2022, as a joint 
project between Diamond and the University of Essex in Colchester.

The project is to use time resolved crystallography to study enzyme reactions 
and mechanisms in multifunctional heme enzymes. Reactions will be followed in 
crystals using spectroscopic approaches to identify appropriate time points. 
There will be opportunities to use XFEL and synchrotron serial crystallography 
beamlines and to carry out complementary biochemical and spectroscopic work. 
Work at Diamond will primarily be at beamlines VMXi and I24.

The closing date is 28th of February 2022 and details are available here: 
https://www.diamond.ac.uk/Careers/Students/Studentships/2022-projects/2022-STU0436.html
 where you can also find application details.

I'd be grateful if BB members could pass this onto any potentially interested 
candidates and/or advertise locally

Informal enquiries can come to me 
(michael.ho...@diamond.ac.uk), or to either 
Robin Owen (robin.o...@diamond.ac.uk) or 
Jonathan Worrall (jworr...@essex.ac.uk).

Thanks,

Mike




Prof Mike Hough
Principal Beamline Scientist - VMXi
Diamond Light Source Ltd
Harwell Science and Innovation Campus



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are not the intended addressee or an authorised recipient of the addressee 
please notify us of receipt by returning the e-mail and do not use, copy, 
retain, distribute or disclose the information in or attached to the e-mail.
Any opinions expressed within this e-mail are those of the individual and not 
necessarily of Diamond Light Source Ltd. 
Diamond Light Source Ltd. cannot guarantee that this e-mail or any attachments 
are free from viruses and we cannot accept liability for any damage which you 
may sustain as a result of software viruses which may be transmitted in or with 
the message.
Diamond Light Source Limited (company no. 4375679). Registered in England and 
Wales with its registered office at Diamond House, Harwell Science and 
Innovation Campus, Didcot, Oxfordshire, OX11 0DE, United Kingdom




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[ccp4bb] PhD studentship available

[Littlechild, Jennifer]

We have a BBSRC supported PhD studentship with Unilever which is advertised 
from Biosciences on the University of Exeter UK web site with a closing date 
12th September.
The overall proposal will be to evaluate and take forward the application of 
already identified thermophilic lactonase enzymes from three different enzyme 
classes to combat microbial biofilm formation towards the improvement of 
Unilever's Healthcare Products. The student will also search through a 
thermophilic genomic and metagenomic DNA database available at Exeter for 
additional related enzymes.
Students with experience in bioinformatics, molecular biology techniques 
including cloning and protein over-expression, protein purification and 
biochemical and structural characterisation, are encouraged to apply on the 
University web site and contact me by email 
j.a.littlech...@exeter.ac.uk as necessary.
Applicants must have obtained, or be about to obtain, a First or Upper Second 
Class UK Honours degree in Biological Chemistry or Biochemistry, or the 
equivalent qualifications gained outside the UK, in an appropriate area of 
science or technology.

Prof of Biological Chemistry, Emeritus, FRSB,FRSC
Henry Wellcome Building for Biocatalysis.
College of Life and Environmental Sciences, Biosciences,
University of Exeter,
EX4 4PQ




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[ccp4bb] PhD studentship Institut de Biologie Structurale, Grenoble, France.

[Franck Borel]

Dear all,
As part of the European ITN MepAnthi project, a PhD student position is 
available in the Synchrotron Group at the “Institut de Biologie Structurale”, 
Grenoble, France.
The project focuses on the development of selective and potent inhibitors of 
the anti-infective targets from MEP pathway (biosynthesis of the isoprenoid 
precursors), which is entirely absent in humans but is essential for medically 
relevant pathogens. The IBS’s task will be the structural analysis of the last 
two enzymes of the pathway (IspG and IspH), using a drug design approach.
Other phD positions are also available from other consortium partners. For 
further information and for application see: 
http://mepanti.hips-wordpress.helmholtz-hzi.de/ 

Regards

Franck BOREL



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[ccp4bb] PhD studentship ILL (France) / Keele University (UK)

[Daouda Traore]

Hi,

An exciting opportunity exists for a PhD student based in the Life Sciences
Group (https://www.ill.eu/lsg) at the Institut Laue-Langevin (ILL) in
France. The project will focus on structural characterisation of a DNA
transfer machinery and is of particular relevance to antibiotic resistance.
The methods used to study this system include neutron and X-ray diffraction
and cryo-EM, alongside the powerful range of technology platforms for
structural biology that are available at the Platform for Structural
Biology (PSB - see https://www.psb-grenoble.eu/). The Grenoble science
campus hosts the ILL neutron beam source, the ESRF synchrotron X-ray
source, and is very well equipped for advanced cryo-EM, including a newly
acquired Titan Krios microsciope.

The student will be based 100% in Grenoble and registered at Keele
University in the UK.

For further information, see

https://www.findaphd.com/phds/project/molecular-architecture-of-a-dna-transfer-machinery-and-its-contribution-to-the-dissemination-of-antibiotic-resistance/?p121089

https://www.ill.eu/careers/all-our-vacancies/phd-recruitment/open-phd-positions/

Regards

Daouda

[image: Logo ILL] 
Daouda A.K. TRAORE
Faculty of Natural Sciences
*Keele University*
Staffordshire ST5 5BG, United Kingdom
*&*
Life Sciences Group
*Institut Max von Laue - Paul Langevin (ILL)*
71, avenue des Martyrs - CS 20156
38042 Grenoble cedex 9 - France
+33 (0)4 76 20 94 94
d.tra...@keele.ac.uk or trao...@ill.eu



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[ccp4bb] PhD studentship (UK): Dynamic Structural Biology – from nanocrystals to time-resolution (CASE project)

[Patrick Shaw Stewart]

The South Coast Biosciences (SoCoBio) Doctoral Training Partnership is
offering a PhD student a unique opportunity to undertake research and
training in structural biology and microfluidics.

https://research.kent.ac.uk/socobio/dynamic-structural-biology-from-nanocrystals-to-time-resolution/



Primary supervisor:
Dr Ivo Tews, Biological Sciences, University of Southampton
Co-supervisors:
Dr S. Mark Roe, School of Life Sciences, University of Sussex
Dr Jonathan West, Medicine, University of Southampton

Project Summary

Significant technical developments are revolutionising structural biology
and change the way in which a crystallographic experiment is approached.
Noise-free detection, advances in synchrotron X-ray sources and
availability of pulsed X-ray free electron laser sources (XFEL) now firmly
establish serial crystallography. Thousands of nanocrystals each contribute
a single x-ray exposure. The method is able to add dynamic information on
structural changes or transitions, observed over time. Enzymes or higher
order molecular complexes are prominent targets.

Micro- or nanocrystalline samples are required to unlock this capability.
We developed a workflow for optimising crystal growth for size and
homogeneity [1] and demonstrated serial data collection with a fixed target
delivery approach using a nano-fabricated chip-based support system,
capable of delivering one structure per hour either at the Diamond Light
Source (I24 microfocus beamline) or at an XFEL source (SACLA, Japan).

The PhD will optimise nano-crystallisation to study two high value targets.
Micro-seeding approaches are developed in collaboration with the highly
innovative CASE partner Douglas Instruments [2]. Novel high-throughput
approaches in nano-crystallisation using microfluidic platforms are
developed at Southampton [3].

*Target 1: Hsp90, a chaperone implicated in maintaining many cancers [4].
Very small crystals of Hsp90 in complex with co-chaperones and client
proteins can be formed (specifically the Hsp90/cdc37/Braf complex). The
size of these crystals is such that they are not suitable for standard data
collection, and serial nano-crystallography will enable structure
determination to understand how Hsp90 aids in protein maturation.*
*Target 2: Pdx1, an enzyme that synthesises vitamin B6 from two
carbohydrates and ammonia. Crystallisation of several key intermediates is
established, and the complex cascade of reactions has been described by us
[5]. Serial data collection to map the highly dynamic changes in the enzyme
is now required, investigating sugar ring opening, ammonia transfer, and
migration of intermediates.*


-- 
 patr...@douglas.co.ukDouglas Instruments Ltd.
 Douglas House, East Garston, Hungerford, Berkshire, RG17 7HD, UK
 Directors: Patrick Shaw Stewart, Peter Baldock, Stefan Kolek

 http://www.douglas.co.uk
 Tel: 44 (0) 148-864-9090US toll-free 1-877-225-2034
 Regd. England 2177994, VAT Reg. GB 480 7371 36



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[ccp4bb] PhD studentship at Umeå University working on Type 4 Secretion Systems

[Ronnie Berntsson]

Dear colleagues,

I have a fully funded PhD studentship available in my lab at Umeå University, 
Sweden. The overall aim of the project is to obtain structural and functional 
data of Gram-positive Type 4 Secretion Systems (T4SS) as well as more divergent 
Gram-negative T4SSs, in order to understand the similarities and differences 
between the two.

The Berntsson lab is part of the Integrated Structural Biology community at 
Umeå University, consisting of 14 research groups that use, and have access to, 
high-field NMR, X-ray crystallography (including regular synchrotron access), 
world-class cryoEM and computation biology with a high performance computing 
centre.

For mor information and to apply, go here:
https://www.umu.se/en/work-with-us/open-positions/phd-studentship-with-focus-on-medical-biochemistrymedical-biophysics_261289/

For informal inquiries, please contact me at ronnie.bernts...@umu.se

Best wishes,
Ronnie

--
Ronnie Berntsson, PhD
Associate Senior Lecturer
Wallenberg Molecular Medicine Fellow
Department of Medical Biochemistry and Biophysics
Umeå University
90187 Umeå
Sweden

e-mail: ronnie.bernts...@umu.se
phone: +46 90 7865235
web: https://www.biostruct.umu.se/principal-investigators/ronnie-berntsson/








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[ccp4bb] PhD studentship at the University of Sussex, Brighton

[Erika Mancini]

Hi All,

I'm posting this on behalf of my colleague Michelle West. Please see below. 
Thanks!

PhD Project: The overall aim of this project is to use biochemical, genomic, 
biophysical and structural biology approaches to study how interactions between 
EBV transcription factors and host cell transcriptional regulators promote B 
cell immortalisation. The project is a collaboration between the groups of 
Professor Michelle West and Dr Chrisostomos Prodromou. 

Application Deadline: 1st of April

To apply, please follow this link:

https://www.findaphd.com/phds/project/molecular-mechanisms-of-host-cell-transcription-factor-hijack-by-the-cancer-associated-epstein-barr-virus/?p107300


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[ccp4bb] PhD studentship at Diamond Light Source and University of Essex: Time-resolved crystallography

[Hough, Mike]

Dear CCP4bbers,

I’d be grateful if you could bring this studentship opportunity to the 
attention of any suitable candidates.


Fully-funded 4 year PhD Studentship: Diamond Light Source and University of 
Essex

Time-resolved synchrotron and XFEL crystallography of metalloenzymes using 
anaerobic photocages


Project outline
X-ray crystallography has been the leading method to understand the structure 
and function of proteins and enzymes for decades. Despite this, it has a key 
limitation in that structures are not time-resolved and so do not represent the 
dynamic and changing nature of a protein’s structure as it carries out its 
function or enzymatic reaction. Time-resolved crystallography is one approach 
for capturing structures of reaction intermediates, though for probing fast 
changes approaches are typically limited to light activated processes.

Metalloproteins are vital to a wide range of biological functions and are 
particularly susceptible to site-specific radiation damage, a problem that is 
considerably worse when working at room temperature. Serial sample delivery and 
the use of photocages to trap and trigger reactions offer a means of resolving 
both of the above challenges, making fast time-resolved experiments applicable 
to a wide range of targets.

In this joint studentship between the University of Essex and Diamond Light 
Source you will perform cutting-edge research in the areas of metalloprotein 
structure determination, serial synchrotron crystallography (SSX), and X-ray 
free electron laser (XFEL) data collection to develop approaches for 
time-resolved SSX at Diamond. To this end you will exploit state-of-the-art 
fixed target instrumentation at Diamond and characterise photocages and their 
activation in crystals. Experiments and developments will be carried out using 
metalloproteins prepared by you at the University of Essex. There will also be
the opportunity to carry out experimental work at the SACLA XFEL in Japan.

You will spend approximately half of the studentship based at the University of 
Essex and half based at Diamond.

We are looking for an exceptional and highly motivated candidate with a good 
Undergraduate or Masters degree in a relevant subject including Life Sciences, 
Physics or Chemistry. A willingness to travel to carry out experimental work at 
international facilities is essential. Start date October 2019.

This interdisciplinary project offers exceptional training opportunities in the 
rapidly developing field of serial and time-resolved structural biology. Full 
training in all required methodology will be provided. The University of Essex 
Proficio scheme offers an extensive range of training courses in transferable 
skills.

Applications should be submitted electronically by the 8th April 2019 see here 
for details 
https://www.essex.ac.uk/pgapply/enter.aspx
 and should state the project title and supervisors. Potential applicants are 
strongly encouraged to informally contact the supervisors in advance: Dr Mike 
Hough (maho...@essex.ac.uk; 
https://www.essex.ac.uk/people/hough20300/mike-hough)
 or Dr Robin Owen (robin.o...@diamond.ac.uk; 
https://www.diamond.ac.uk/Instruments/Mx/I24/Staff/Owen.html)

For general information about the School of Biological Sciences at the 
University of Essex please visit our webpages 
http://www.essex.ac.uk/bs/.
 For information regarding macromolecular crystallography beamlines at Diamond 
please visit 
https://www.diamond.ac.uk/Instruments/Mx
Funding Notes

This is a fully-funded 4-year PhD Studentship covering Home/EU fees and with an 
enhanced stipend.
Please note: International students need to have additional funding to cover 
the difference in tuition fees which is currently £12,410 per year, evidence 
will be requested that you have these additional funds.

Further details are here:
https://www.findaphd.com/phds/project/time-resolved-synchrotron-and-xfel-crystallography-of-metalloenzymes-using-anaerobic-photocages/?p106337\

Many thanks!

Mike




Dr Michael Hough
Senior Lecturer in Structural Biology
School of Biological Sciences
University of Essex
Wivenhoe Park, Colchester
CO4 3SQ
United Kingdom
Phone number: +44 1206 87 3317

[ccp4bb] PhD studentship at University of Geneva, Switzerland; Structural and biochemical analysis of inositol pyrophosphate signaling pathways

[Michael Hothorn]

Applications are invited for a PhD position, starting any time in 2019, 
in the group Prof. Michael Hothorn at University of Geneva 
(http://structplantbio.org). The lab combines structural biology (X-ray 
protein crystallography, cryo electron microscopy) and quantitative 
biochemistry with genetics and cell biology to dissect novel signal 
transduction pathways required for plant growth and development. The 
successful candidate will investigate how inositol pyrophosphate 
signaling molecules involved in nutrient signaling interact with 
different plant signaling proteins and protein complexes. She/he will 
use state-of-the art molecular biology, protein biochemistry and 
structural biology techniques to characterize these interactions in 
molecular detail.


The candidate should have a first class degree in biochemistry or 
closely related subject and ideally prior experience in molecular 
biology and in protein biochemistry. A basic knowledge of protein 
expression and purification, quantitative biochemistry, and in protein 
crystallography or cryoEM would be highly appreciated.


Applications should be sent Prof. Michael Hothorn 
(michael.hoth...@unige.ch) as a single PDF document, containing a 2 page 
CV (including details on the final grade or the expected grades) and a 
motivational statement of up to 2 pages. Applicants should also include 
contact details of 2-3 academic referees.


Informal inquiries can be addressed by email to Prof. Michael Hothorn  
(michael.hoth...@unige.ch). More information can be found here: 
http://structplantbio.org


The successful candidate will receive an internally funded, full-time 
PhD contract for up to 5 years.


_References_

Zhu J, Lau K, Harmel RK, Puschmann R, Broger L, Dutta AK, Jessen HJ, 
Hothorn LA, Fiedler D, Hothorn M (2019) Two bifunctional inositol 
pyrophosphate kinases/phosphatases control plant phosphate homeostasis. 
bioRxiv doi: https://doi.org/10.1101/467076
Hohmann U, Nicolet J, Moretti A, Hothorn LA, Hothorn M (2018) The SERK3 
elongated allele defines a role for BIR ectodomains in brassinosteroid 
signalling. Nature Plants 4:345-351 doi: 10.1038/s41477-018-0150-9
Hohmann U, Santiago J, Nicolet J, Olsson V, Spiga FM, Hothorn LA, 
Butenko MA, Hothorn M (2018) Mechanistic basis for the activation of 
plant membrane receptor kinases by SERK-family coreceptors. PNAS 
115(13):3488-3493
Wild R†, Gerasimaite R†, Jung JY†, Truffault V, Pavlovic I, Schmidt A, 
Saiardi A, Jessen HJ, Poirier Y*, Hothorn M*, Mayer A* (2016) Control of 
eukaryotic phosphate homeostasis by inositol polyphosphate sensor 
domains. Science 352(6288):986-90





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[ccp4bb] PhD studentship at Queen Mary University of London (Targeting myosin for heart disease: a structure-based approach to design conformation-selective modulators)

[Arianna Fornili]

Applications are invited for a PhD studentship starting from September 2019 in 
Dr. Arianna Fornili’s group at Queen Mary University of London and in 
collaboration with Dr. Julien Ochala at King’s College London.
The aim of the project is to design and test small molecules that can either 
inhibit or activate cardiac myosin, a key component of the molecular machinery 
involved in heart contraction. A combined computational/experimental approach 
will be used, which will involve the use of molecular dynamics, molecular 
docking, virtual screening and in vitro biophysical techniques.
Applications are welcome from outstanding students with, or expecting to 
obtain, a first or upper-second class honours degree in Chemistry, 
Pharmaceutical Chemistry, Biochemistry, Physics, Biophysics or related 
disciplines. A masters degree is desirable. Previous experience in molecular 
modelling/simulation is essential, previous experience in computer programming 
and/or experimental biophysical techniques is a plus.
The studentship is funded by EPRSC and will cover tuition fees and an annual 
tax-free maintenance allowance at the Research Council rate (£16,777 in 
2018/19) for 3.5 years. UK students, and EU students who have been ordinarily 
resident in the UK for at least 3 years are normally eligible for full EPSRC 
funding.
For more information:
https://www.qmul.ac.uk/sbcs/postgraduate/phd-programmes/projects/display-title-649759-en.html
https://www.findaphd.com/phds/project/targeting-myosin-for-heart-disease-a-structure-based-approach-to-design-conformation-selective-modulators/?p105203
Before submitting a formal application online, please contact Dr. Fornili 
(a.forn...@qmul.ac.uk) and include your CV, your 
academic transcripts, a cover letter explaining eligibility and interest in the 
project and the contact details of two academic referees. The deadline for 
formal applications is on the 31st of January 2019.
Dr. Arianna Fornili
Lecturer in Computational Organic Chemistry
School of Biological and Chemical Sciences
Joseph Priestley Building (room G.04)
Queen Mary, University of London
Mile End Road
E1 4NS London UK
email: a.forn...@qmul.ac.uk
Tel: +44 (0) 207 882 8446
website: https://afornililab.wordpress.com




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[ccp4bb] PhD studentship - Glasgow University/Astra Zeneca

[Laura Spagnolo]

Dear Colleagues,
Applications are invited for a PhD studentship position funded by the 
BBSRC-CASE scheme in the laboratory of Dr Laura Spagnolo, University of 
Glasgow, in collaboration with Dr Taiana Maia de Oliveira, Astra Zeneca, 
Cambridge. The project involves the cryo-electron microscopy study of large 
protein/nucleic acid complexes involved in the maintenance of genome stability.
Candidates should have a first or upper second class degree in biochemistry, 
cell biology or biological/medical science. The successful candidate will have 
the opportunity to work in both academic and industry setting during their 
studentship. The studentship is available to UK nationals and EU students who 
meet the UK residency requirements.
To apply, please send a CV and cover letter to 
laura.spagn...@glasgow.ac.uk. The closing 
date for applications is April 20th, 2018.
Best regards,
Laura



Dr Laura Spagnolo
Reader in Structural Biology
Institute of Molecular, Cell and Systems Biology
University of Glasgow
Room 409, Bower Building
University Avenue
Glasgow G12 8QQ
United Kingdom

Tel. + (0)141 3305133





[University of Glasgow: The Times Scottish University of the Year 2018]

[ccp4bb] PhD Studentship opportunity at University of Essex

[Hough, Mike]

Dear CCP4bb,

I would like to bring to your attention a PhD studentship opportunity in my 
group, which I would be grateful if you would advertise to potential candidates.

The details are available here:

https://www.findaphd.com/search/ProjectDetails.aspx?PJID=94398

and

https://www1.essex.ac.uk/bs/documents/research_documents/MH-JW-RS-DS-advert.pdf


The project will involve the study of two biotechnological important enzymes 
and will offer the opportunity to conduct synchrotron and XFEL crystallography, 
fast kinetics and EPR.

The closing date is at the end of February.

Many thanks,

Mike

[ccp4bb] PhD studentship at the FHS Macau - William Chao Lab

[williamchao]

PhD studentship in Biomedical Sciences

The laboratory of Dr William Chao is seeking a highly motivated PhD candidate 
to perform structural studies on key cell‐cycle protein complexes.

The laboratory focuses on using structural biology and recombinant systems to 
investigate crucial cell‐cycle mechanisms. Dr Chao has extensive experience in 
determining multi‐subunit protein complexes and nurtures a collaborative spirit 
in pursuing key biological questions.

The appointed student will participate in the research project of “Structural 
Studies of Cell‐Cycle Protein Complexes”. He/she will be given the opportunity 
to master state‐of‐the‐art techniques in protein complex reconstitution and 
structure determination as well as learning new techniques from collaborators’ 
laboratories.

Applicants must hold a bachelor or master degree in relevant areas of natural 
sciences.  Previous experience in molecular biology and structural biology will 
be of advantage.

For further information, please contact William Chao @ 
williamc...@umac.mo and visit
https://fhs.umac.mo/staff/academic-staff/williamchao/ and 
https://williamchao.wixsite.com/williamchaolab

Normative Study Period
4 years.

Tuition Fee and Post‐graduate Assistantship
The current Tuition Fee Scheme is credit‐based.  All full‐time PhD students in 
the Faculty receive post‐graduate assistantship of MOP12,500/month, which will 
be increased to MOP14,000/month after students passing the qualifying 
examination and thesis proposal assessment. For further information, please 
visit
Graduate School website - http://www.umac.mo/grs/en/admissions.php

The FHS Macau
The Faculty of Health Sciences (FHS) at the University of Macau is a leading 
research and education institution in biomedical sciences.  The Faculty aims to 
tackle the fast‐evolving global health challenges through cutting‐edge research 
and by nurturing new talent in biomedical sciences. For further information, 
please visit
FHS website ‐ https://fhs.umac.mo/
University website ‐ http://www.umac.mo/

Macau
With over 300 years of cultural fusion between the East and the West, Macau is 
a glittering international city in the southern coast of China (1hr from Hong 
Kong). It is an ideal destination for those who wish to explore the Far East 
while enjoy the Mediterranean European culture. For further information, please 
visit
https://www.lonelyplanet.com/china/macau
https://en.wikipedia.org/wiki/Macau

[ccp4bb] PhD studentship in Structural Biology and Chromatin available at University of Oslo

[Nikolina Sekulic]

Dear all,

I have an opening for PhD student in my group and I would be grateful if
you can circulate this info between interested groups in your environment.

Thanks in advance,

Nikolina

Nikolina Sekulic, PhD
Group leader, Structural Biology and Chromatin
Norwegian Center for Molecular Medicine (NCMM)
Associate Professor, Department of Chemistry, University of Oslo
Gaustadalléen 21
Forskningsparken 0349 OSLO
Office: +47 22840511

---

PhD Research Fellowship in Structural Biology and Chromatin

A 3 year PhD fellowship is available in the Group for Chromatin and
Structural Biology.

The Group for Structural Biology and Chromatin (Sekulic Group
)
investigates chromatin biology and epigenetics with a biochemical and
structural approach. The project aims at understanding changes in chromatin
during mitosis and kinetochore formation. We use various biochemical and
biophysical approaches (X-ray crystallography, SAXS, SANS,
hydrogen-deuterium exchange ...). In addition, we collaborate with cell
biology groups to link structure with function.

Sekulic group is affiliated with both the Faculty of Medicine and the
Department of Chemistry at the Faculty of Mathematics and Natural Sciences.
The PhD student will also benefit from career development programs offered
both at UiO as well as the Nordic EMBL network of the Centre for Molecular
Medicine, Norway.

*PhD candidate*: A three-year position is available immediately. We seek
highly motivated individuals with an excellent track record and experience
in protein purification and biophysical and biochemical characterization of
proteins and protein complexes. Experience in the field of structural
biology and mass spectrometry techniques is an advantage. We offer
stimulating environment with excellent working and social benefits.

The purpose of the fellowship is research training leading to the
successful completion of a PhD degree.

The fellowship requires admission to the PhD program at the Faculty of
Mathematics and Natural Sciences. The application to the PhD program must
be submitted to the department no later than two months after taking up the
position. For more information see:

http://www.mn.uio.no/english/research/phd/

http://www.mn.uio.no/english/research/phd/application/application.html

*The ideal candidate will have:*
• A Master’s degree in biochemistry, chemistry, molecular biology or a
related area
• Hands-on experience with purification of proteins and assembly of protein
complexes
• Ability to independently perform experiments, analyze and interpret the
results
• Excellent interpersonal/communication skills
• Excellent written and oral English
• Ability to operate as a team player in a multi-disciplinary environment

*The application must include:*
• Cover Letter stating motivation and research interests
• CV
• Copies of certificates and grades with explanation of the grading system
• A complete list of scientific publications
• List of references (name, relation to candidate, e-mail and telephone
number)

Foreign applicants are advised to attach an explanation of their
University’s grading system. Please remember that all documents should be
submitted in English.

In accordance with the University of Oslo's equal opportunities policy, we
invite applications from all interested individuals regardless of gender or
ethnicity.

UiO has an agreement for all employees, aiming to secure rights to research
results a.o.  Note that no one can be appointed for more than one specified
period at the same institution.

*Salary:* The position will be placed as SKO 1017 (position code) with
salary depending on qualifications within step 50-57 (NOK 436 900 – 490
900  per year) depending on qualifications and seniority.

*Inquiries:*
About the position: Group Leader,  Nikolina Sekulic (
nikolina.seku...@biotek.uio.no).
About administrative aspects of the application: Nina Modahl (
ni...@ncmm.uio.no).


Please submit your application through the web-based recruitment
system linked to the announcement.

https://www.jobbnorge.no/en/available-jobs/job/144835/phd-research-fellowship-in-structural-biology-and-chromatin

[ccp4bb] PhD studentship to study enzymes involved in metabolic diseases

[Elton Zeqiraj]

Dear CCP4 Community,

Please see below for details of a 4-year PhD studentship at the University of 
Leeds with an industry placement at a pharmaceutical company.  

For details on how to apply follow instructions in the link below: 
https://www.findaphd.com/search/ProjectDetails.aspx?PJID=74943=735 


Best wishes,
Elton

**
Elton Zeqiraj, PhD
Sir Henry Dale Fellow
Astbury Centre for Structural Molecular Biology
School of Molecular and Cellular Biology
Faculty of Biological Sciences
Astbury Building, Room 8.109
University of Leeds,
Leeds,
LS2 9JT, 
UK

Tel: +44 113 3433079
email: e.zeqi...@leeds.ac.uk 
web: www.personal.leeds.ac.uk/~fbsez 
**

Please consider the environment.  Do you really need to print this email?



Title: Structure-function, mechanism of action and therapeutic potential of 
enzymes involved in metabolic diseases

Project Description

We are excited to offer a PhD studentship to study enzymes involved in 
metabolic diseases. 
The studentship offers a unique opportunity to experience research at a 
world-class academic institution and a multinational pharmaceutical company. An 
industry placement (minimum of 3 months) at Vertex Pharmaceutical’s site in 
Abingdon (Oxfordshire) will take place in year 3 or 4 of the studentship. 

Techniques you will learn and use: 
- Cryo-electron microscopy and/or X-ray crystallography for determining 
structures of proteins and protein-protein complexes 
- Enzyme substrate kinetic measurements and enzyme inhibition 
- Biophysical techniques such as Fluorescence Polarisation and calorimetry 
- Cell biology and Cellular imaging assays 

The project will suit someone interested in structural biology, enzymology, 
biochemistry and drug discovery. Experience in structural biology is not 
required and suitable training will be provided. 

The Astbury Centre for Structural & Molecular Biology at the University of 
Leeds has excellent facilities for cryo-electron microscopy (two Titian Krios 
300 kV), protein crystallography (crystallisation robots, automatic imaging), 
and protein production with expertise in multi-subunit expression in insect 
cell, yeast and bacterial expression systems. The Astbury Centre is also 
well-equipped with instrumentation for biophysical analysis (e.g. ITC, 
fluorescence, multi-angle light scattering). Additionally, the University 
provides a state-of-the-art infrastructure for mammalian cell culture, 
high-throughput screening, imaging, mammalian genetics, chemical biology and 
proteomics. 

The University of Leeds was named University of the Year 2017 by The Times and 
The Sunday Times’ Good University Guide. 

As well as the stipend below, the successful candidate will receive an annual 
supplement of £2,500 from the industrial partner. 

Informal enquires can be made to Dr Elton Zeqiraj (e.zeqi...@leeds.ac.uk 
).

Funding Notes

To start in Oct 2017. Applicants should have, or be expecting to receive, a 2.1 
Hons degree in a relevant subject. 

This project is eligible for BBSRC funding. We are advertising a range of 
projects and funding will be awarded to the best candidates. The funding covers 
fees at UK/EU level plus a stipend of £14,553 for 4 years. Please note that 
candidates must have been resident in the UK for the last 3 years to be 
eligible for full funding; candidates who have not been resident in the UK are 
eligible for a fees-only studentship. 

https://www.findaphd.com/search/ProjectDetails.aspx?PJID=74943=735 
 

[ccp4bb] PhD studentship on cryoEM data analysis

[Tom Burnley]

Posted on behalf of Peijun and Kevin:

Dear All,

A joint PhD studentship between Diamond Light Source and University of York
is available to Develop tools to automatically assess the quality and
resolution of cryoEM reconstructions. Please see the link below for
detailed information and how to apply.

http://www.diamond.ac.uk/Careers/Studentships/untitled0.html

Informal enquiries may be addressed to either supervisor:

Peijun Zhang, peijun.zh...@diamond.ac.uk, Diamond Light Source
Kevin Cowtan, kevin.cow...@york.ac.uk, University of York

-- 
Dr Tom Burnley, PhD
CCP-EM | @ccp_em | www.ccpem.ac.uk

Science and Technology Facilities Council (STFC)
The Research Complex At Harwell
Rutherford Appleton Laboratory, R92
OX11 0FA
01235 56 7871

[ccp4bb] PhD Studentship in Meiotic Chromosome Structure

[Owen Davies]

Dear colleagues,

I would like to advertise a PhD studentship that is available in my lab to 
study the molecular structure of meiotic chromosomes through biochemistry and 
structural biology. The details of the project are as follows:

PhD studentship in Biochemistry and Structural Biology - The Molecular 
Structure of Meiotic Chromosomes
The reduction in chromosome number during meiosis is essential for the 
production of haploid germ cells that produce healthy offspring upon 
fertilisation. This is achieved through an elaborate cellular process of 
chromosome 'choreography' during meiotic prophase, in which errors lead to 
infertility, miscarriage and genetic disorders such as Down's syndrome. Rapid 
chromosomal movements enable the identification and synapsis of homologous 
chromosome pairs. Once achieved, homologues exchange genetic material through 
crossing over and are then moved into position at metaphase to enable their 
correct segregation into haploid cells. This intricate process depends upon 
chromosome telomeric ends being tethered to the nuclear envelope by the 
meiotic-telomere complex (MAJIN, TERB1, TERB2, TRF1) and connected to the 
cytoskeleton by the LINC complex (SUN1, KASH5). However, whilst essential for 
meiosis, we currently lack essential molecular understanding regarding their 
structure and function.

This PhD project aims to elucidate the molecular structure of the 
meiotic-telomere and LINC complexes, and their mechanisms of interaction with 
telomeres and the cytoskeleton. It will involve recombinant protein 
purification, biochemistry, biophysics (including SEC-MALS, SEC-SAXS, CD and 
EM) and X-ray crystallography. This project is part of an international 
collaboration with EM tomography, genetics and cellular biology groups, and 
will likely result in high impact research findings in the fields of cell 
division and chromosomal biology. The successful candidate will be a 
highly-motivated individual with interests in solving fundamental molecular 
questions of cellular function through structural biology.

Funding details
Each award is worth £18,500 per year, paying the UK/EU PhD tuition fees and 
providing annual living expenses of £14,057. Total value of each award is 
£74,000.

Eligibility Criteria
You must have, or expect to achieve, at least a 2:1 Honours degree or 
international equivalent in biochemistry or a related area. A further 
qualification such as an MSc or MRes is advantageous.

This award is available to UK/EU and international applicants; the studentship 
pays fees at the UK/EU level so international candidates would be liable for 
the additional international fees. If English is not your first language, you 
must have IELTS 7 with at least 6.5 in the written component, or equivalent.

Start date and duration
September 2017 for a three year PhD.

Application closing date
5th April 2017

Advert website
http://www.jobs.ac.uk/job/AXO859/phd-studentship-in-biochemistry-and-structural-biology-the-molecular-structure-of-meiotic-chromosomes/

How to apply
You must apply through the University's online postgraduate application system. 
To do this please 'Create a new 
account'.  Only mandatory fields need 
to be completed. However, you will need to include the following information:

  *   insert the programme code 8300F in the programme of study section
  *   select 'PhD in the Faculty of Medical Sciences - Cell and Molecular 
Biosciences' as the programme of study
  *   insert the studentship code CB131 in the studentship/partnership 
reference field
  *   attach a covering letter and CV. The covering letter must state the title 
of the studentship, quote the studentship reference code CB131 and state how 
your interests and experience relate to the project
  *   attach degree transcripts and certificates and, if English is not your 
first language, a copy of your English language qualifications.

Please also feel free to contact me directly with any further queries.

Best wishes,

Owen Davies.

Dr Owen Davies
Wellcome Trust and Royal Society Sir Henry Dale Fellow
Institute for Cell and Molecular Biosciences
Faculty of Medical Sciences
Newcastle University
United Kingdom

Telephone: +44 (0)191 208 7371
e-mail: owen.dav...@newcastle.ac.uk
website: http://www.ncl.ac.uk/camb/staff/profile/owen.davies

[ccp4bb] PhD studentship in Structural Biology

[Vidya Darbari]

Dear All,

I would be very grateful if you would kindly circulate the PhD studentship 
opportunity to any promising students in your Departments/Schools/Institutes.

Applications are invited for a Ph.D studentship to start in Oct 2017 in Dr. 
Vidya Darbari’s group in Queen Mary University of London to investigate 
transcription regulation by regulatory RNAs using structural biology 
techniques. Closing Date: 17th March.

Detailed information available at 
https://www.findaphd.com/search/ProjectDetails.aspx?PJID=76235

Applications are welcome from outstanding European/UK students with or 
expecting to obtain a first or upper-second class degree in Chemistry, 
Biochemistry, Biophysics or related disciplines. An MSc in appropriate subject 
and laboratory experience may be an advantage, but are not essential. The 
studentship will cover tuition fees and provide an annual tax-free maintenance 
allowance for 3 years at Research Councils UK rates (£16,296 in 2016/17).

For informal enquires please contact Dr. Darbari 
(v.darb...@qmul.ac.uk) and include your CV, a 
covering letter explaining eligibility and interest in the project and the 
contact details of two academic referees.

Applications are via the QMUL web-site.

Best Regards
Vidya


Dr. Vidya Chandran Darbari
Lecturer in Structural Biology
Office 4.34 Fogg building
Department of Chemistry and Biochemistry
School of Biological and Chemical Sciences
Queen Mary University of London
Mile End Road
London E1 4NS
Tel: 0207 882 6360

[ccp4bb] PhD studentship available

[Simon Kolstoe]

Dear all,

If you have any promising undergraduate or masters level students I would be 
grateful if you could point them to the following, funded, PhD opportunity in 
my laboratory. They are welcome to send me an email for an informal chat prior 
to an application.

"Molecular basis of C-reactive protein (CRP) binding to the lipid bilayer – a 
flag for complement targeting and the generation of pro-inflammatory signals in 
the innate immune system"

https://www.findaphd.com/search/ProjectDetails.aspx?PJID=81668=1286

Structural studies of biological macromolecules and their interactions underpin 
our understanding of function and guide the development of drug interventions 
to combat disease. The aim of this project is to define the structural detail 
of the interaction of the pentameric human acute phase C-reactive protein (CRP) 
with compromised lipid bilayers. This targets the innate immune system to 
resolve tissue damage, but also produces a monomeric variant of CRP that 
generates pro-inflammatory signals. The PhD project student will express and 
purify native and mutated forms of CRP from tissue culture cells, and 
crystallise the proteins in cubic lipid phase for structure analysis by X-ray 
diffraction methods. This will help to understand how CRP differentiates 
between sick and healthy cells. 

An experienced team working in the biophysics and crystallography of CRP will 
supervise the student. There will be opportunities to work at the Membrane 
Protein Laboratory (Harwell) and collect X-ray diffraction data at a 
synchrotron radiation source. In addition there will be access to a large 
number of training resources available through the graduate school including 
those geared toward improving presentation skills, time-management and project 
organisation skills, reviewing literature, thesis writing, data analysis and 
statistics, 
and related training modules. 

Portsmouth is a vibrant waterfront city on the south coast of England and is 
within easy reach of London. The city is compact and friendly with the 
university at its heart. More information about living in the city and working 
at the university can be seen here: http://www.port.ac.uk/virtualtour/

Funding Notes

Home/EU applicants only. Please use the online application form and state the 
project code (BIOL2900217) and studentship title in the personal statement 
section. 

Funds will be provided for 3 or 4 years which will include: bursary (at current 
RCUK rates), University fees (UK/EU rate).

Thanks,

Simon

[ccp4bb] PhD Studentship in mTORC1 Signalling in Autophagy and Ageing

[Owen Davies]

Dear colleagues,

A 3.5-year PhD studentship is available to study the molecular mechanism of 
mTORC1 signalling in autophagy, cellular ageing and age-related diseases 
through an interdisciplinary approach of biochemistry, biophysics, X-ray 
crystallography and cellular biology. It will be based in my lab and will 
include an extended rotation period with Dr Viktor Korolchuk, in Newcastle. The 
details of the project are as follows:

The molecular mechanism of mTORC1 signalling in autophagy, cellular ageing and 
age-related diseases through biochemistry, structural biology and cellular 
biology
The mammalian 'Target of Rapamycin Complex' (mTORC1) controls cellular growth 
and proliferation in response to nutrient availability. This fundamental 
cellular signalling mechanism permits growth of cells when sufficient nutrients 
(particularly amino acids) are present, and is thereby essential for the growth 
of our cells and tissues (Bar-Peled and Sabatini 2014, Trends Cell Biol). 
However, this same mechanism can become detrimental during ageing, when TORC1 
signalling contributes to organismal decline and age-related diseases such as 
Alzheimer's disease, heart disease and cancer (Laplante and Sabatini 2012, 
Cell). Indeed, the relevance of mTORC1 signalling to ageing has been 
highlighted by interventions such as calorie restriction or rapamycin 
treatment, which suppress this pathway and have been shown to extend life-span 
and prevent age-related illnesses. In such cases, nutrient starvation or direct 
inhibition trigger autophagy, a process of self-degradation in which damaged 
cellular material is removed and recycled to allow the repair of tissues.

This PhD project aims to understand how amino acids are recognised by the 
mTORC1 machinery and how this results in activation of the pathway. We have 
identified a novel mechanism of mTORC1 activation by amino acids which act by 
blocking the inhibition of master mTORC1 activator Rheb by negative regulator 
TSC2 (Carroll et al 2016, eLife). This simple signalling pathway has numerous 
possibilities for exploitation in the new therapeutics that may slow or delay 
the development of age-related diseases, and so this PhD project aims to 
uncover the precise molecular mechanism whereby this process is achieved. We 
will use a combination of biochemical, structural biology and cellular biology 
methods to determine the atomic resolution structure of the TSC2-Rheb complex, 
the basis of its inhibition by amino acids, and the molecular mechanism whereby 
Rheb activates mTORC1 within the cell.

This interdisciplinary PhD project will be based in the laboratories of Dr Owen 
Davies and Dr Viktor Korolchuk in the Institute of Cell and Molecular 
Biosciences, Newcastle University, and will provide an unprecedented level of 
training in a wide variety of techniques. These will include molecular cloning, 
recombinant protein expression and purification, biophysical methods (including 
SEC-MALS, SEC-SAXS, ITC, MST, CD and EM) and X-ray crystallography, in addition 
to mammalian cell culture, genetic modification of cell lines, 
immunofluorescence and flow cytometry.

This project will provide a crucial step towards being able to manipulate 
mTORC1 and its deregulation in ageing. We envisage that this will catalyse 
future translational research into therapeutic targeting of age-related 
disease, which will have clear and fundamental implications for medicine.

Funding details
MRC DiMeN DTP studentships are funded for 3.5 years and include:
Tax-free maintenance grant set at the UK Research Council's national rate.
Full payment of tuition fees at the Home/EU rate.
A Research Training Support Grant to support your research studies.

Successful Home students will receive a full studentship. EU students will be 
considered for a full studentship/fees only support depending on the excellence 
of their qualifications and their employment/residency status.

Advert website
https://www.findaphd.com/search/ProjectDetails.aspx?PJID=80881=3415

To apply
For more information about the PhD programme and to apply please visit the 
DiMeN website:
http://www.dimen.org.uk/

Closing date for applications
6th January 2017

Please also feel free to contact me directly with any further queries.

Best wishes,

Owen Davies.

Dr Owen Davies
Wellcome Trust and Royal Society Sir Henry Dale Fellow
Institute for Cell and Molecular Biosciences
Faculty of Medical Sciences
Newcastle University
United Kingdom

Telephone: +44 (0)191 208 7371
e-mail: owen.dav...@newcastle.ac.uk
website: http://www.ncl.ac.uk/camb/staff/profile/owen.davies

[ccp4bb] PhD Studentship in Meiotic Chromosome Structure and Recombination

[Owen Davies]

Dear colleagues,

A four-year PhD studentship is available to study meiotic chromosome structure 
and recombination through biochemistry, biophysics, X-ray crystallography and 
bioinformatics. It will be based in my lab in Newcastle and will include an 
extended rotation period with Dr Dan Rigden in Liverpool. The details of the 
project are as follows:

The molecular structure and function of the synaptonemal complex in chromosome 
synapsis and recombination during meiosis
Meiosis, the process of reductive cell division, is essential for fertility and 
genetic diversity in all sexually reproducing organisms. At the centre of this 
process is the synaptonemal complex (SC), a protein superstructure that acts a 
molecular 'zipper' to bind together homologous chromosomes along their entire 
length. The three-dimensional architecture of the SC imposes the necessary 
chromosomal structure and provides the physical framework for meiotic 
recombination and crossover formation. These processes are achieved through 
homologous recombination-mediated DNA double-strand break repair pathways, and 
are essential for fertility. Defects in synaptonemal complex formation lead to 
infertility, recurrent miscarriage and aneuploidies such as Down's syndrome, in 
addition to germline cancers. However, whilst the protein building blocks of 
the synaptonemal complex have been identified in both humans and yeast, the 
structure of the complex and its molecular function in meiosis remain unknown.

This PhD project aims to elucidate the molecular structures of the principal 
yeast SC components Zip1 and Ecm11-Gmc2, and to determine their mechanism of SC 
assembly. This will be achieved through recombinant protein purification, a 
range of biophysical techniques (including SEC-MALS, SEC-SAXS, CD and EM), 
X-ray crystallography, yeast two-hybrid and genetics, and computational 
bioinformatics. It will therefore involve an unprecedented level of 
multi-disciplinary training. We will combine the resulting molecular 
information with our ongoing studies on the human SC to define the underlying 
molecular basis for SC function across eukaryotes. This will enable us to 
translate directly between human and yeast systems, allowing us to exploit the 
genetic tractability of yeast in a manner that is directly applicable to our 
understanding of human fertility. Ultimately, we aim to engineer a chimeric 
system in which a humanised SC is assembled and functional in yeast, and thus 
establish a truly genetically tractable cellular system for studying a full 
human SC in vivo.

The PhD studentship is cross-institutional, and will be based primarily at 
Newcastle University, with Liverpool University hosting an extended rotation 
period and providing support as necessary throughout for the bioinformatics 
work. The project will be supervised by Dr Owen Davies (Newcastle) and Dr Dan 
Rigden (Liverpool), and is part of a collaboration with EM tomography, genetics 
and cellular biology groups within the institute and worldwide, with whom we 
will test our biochemical and crystallographic findings in cellular models. 
This project should result in highly publishable and high impact research 
findings in the fields of meiotic cell division, chromosomal biology and X-ray 
crystallography. The successful candidate will be a highly motivated individual 
with interests in solving fundamental molecular questions of cellular function 
through both practical structural biology and computational approaches.

Funding details
This is a 4 year BBSRC studentship under the Newcastle-Liverpool-Durham DTP. 
The successful applicant will receive research costs, tuition fees and stipend 
(£14,296 for 2016-17). The PhD will start in October 2017. Applicants should 
have, or be expecting to receive, a 2.1 Hons degree (or equivalent) in a 
relevant subject. EU candidates must have been resident in the UK for 3 years 
in order to receive full support. There are 2 stages to the application process.

Advert website
https://www.findaphd.com/search/ProjectDetails.aspx?PJID=80667=1120

To apply
Please submit a full CV and covering letter directly to 
owen.dav...@newcastle.ac.uk

Please also feel free to contact me directly with any further queries.

Best wishes,

Owen Davies.

Dr Owen Davies
Wellcome Trust and Royal Society Sir Henry Dale Fellow
Institute for Cell and Molecular Biosciences
Faculty of Medical Sciences
Newcastle University
United Kingdom

Telephone: +44 (0)191 208 7371
e-mail: owen.dav...@newcastle.ac.uk
website: http://www.ncl.ac.uk/camb/staff/profile/owen.davies

[ccp4bb] PhD studentship at Queen Mary University of London (In silico study of the effects of pathogenic mutations on the structure and dynamics of heart muscle proteins)

[Arianna Fornili]

Applications are invited for a PhD studentship in Dr. Arianna Fornili's group 
at Queen Mary University of London starting from October 2015.

Using a combination of state-of-the-art Molecular Modelling, Molecular Dynamics 
and Bioinformatics techniques, the successful candidate will investigate how 
cardiomyopathy-related mutations affect the motion and stability of key 
components of the cardiac sarcomere.

Applications are welcome from outstanding European/UK students with or 
expecting to obtain a degree in Chemistry, Biochemistry, Physics, Biophysics or 
related disciplines. Previous experience in molecular modelling/simulation 
and/or computer programming is desirable but not essential.

For more information: 
http://www.sbcs.qmul.ac.uk/prospectivestudents/research/projects/147840.html
http://www.findaphd.com/search/ProjectDetails.aspx?PJID=61492LID=1316

For informal enquires please contact Dr. Fornili (a.fornili at 
qmul.ac.ukhttp://qmul.ac.uk/) and include your CV, a covering letter 
explaining eligibility and interest in the project and the contact details of 
two academic referees. The deadline for formal applications is 5 pm (GMT) on 09 
March 2015.

Dr. Arianna Fornili
BHF Research Fellow
School of Biological and Chemical Sciences
Joseph Priestley Building (room G.04)
Queen Mary, University of London
Mile End Road
E1 4NS London UK
email: a.fornili at qmul.ac.ukhttp://qmul.ac.uk
Tel: +44 (0) 207 882 8446

[ccp4bb] PhD studentship opportunity in

[Mike Hough]

Dear CCP4ers,

Could you please pass on details of this studentship opportunity to any 
suitable candidates?

Many thanks,

Mike



Fully-funded three year PhD Studentship: April 2015 
Generating Structural Movies of Enzyme Catalysis 
Supervisor: Dr Mike Hough, University of Essex 

Project Overview 
X-ray crystal structures of enzymes are vital to our understanding of biology. 
Such structures, however, provide only discrete static steps of dynamic enzyme 
mechanisms. In this Leverhulme Trust-funded project you will use state of the 
art technology breakthroughs to overcome this limitation by creating 
‘structural movies’ that fully reveal the catalytic functions of enzymes at 
atomic resolution. X-rays will be used to generate electrons within protein 
crystals. These electrons will migrate to redox centres and be used to initiate 
and drive enzyme catalytic cycles at will. Tools will be developed using 
emerging technologies, including ultrafast X-ray detectors allowing structures 
be measured in rapid succession,. Enzyme states generated in this way are 
representative of those in vivo, where the electrons that drive reactions would 
be provided by biological electron transfer. 
The successful applicant will develop skills in recombinant protein expression, 
protein crystallization, synchrotron X-ray crystallography, several single 
crystal spectroscopies and advanced data analysis. The PhD student will also 
have the exciting opportunity to work and conduct experiments at the Diamond 
Light Source UK (http://www.diamond.ac.uk/Home.html), the Swiss Light Source 
(http://www.psi.ch/sls/swiss-light-source) and the European Synchrotron 
Radiation Facility (http://www.esrf.eu/). 

A generous stipend is provided and Home/EU fees are fully covered. 
https://www.essex.ac.uk/pgapply/enter.aspx 
Requirements: A first or upper second class degree or MSc Merit/Distinction in 
a relevant subject. The successful candidate will have strong organizational 
skills, with good oral and written communication. The candidate will be 
self-motivated and a team player. 
Informal enquiries should be addressed to Dr Mike Hough maho...@essex.ac.uk 
Apply via: 
Deadline for applications: 31st January 2015 

[ccp4bb] PhD studentship at the University of Manchester

[Balvinder Dhaliwal]

Dear All,



   Applications are invited for a PhD studentship at the Manchester
Institute of Biotechnology, University of Manchester.


   The project will involve the structural and functional characterization
of food allergens and their complexes. The techniques used will include
cloning, protein purification, in vitro digestion, mass spectrometry
(HDX-MS, IM-MS), crystallography, and cell-based assays.


Project details and how to apply can be found at: -

  http://www.findaphd.com/search/projectDetails.aspx?PJID=58003


   The deadline for applications is 26th November 2014.

   Informal enquires may be made to Balvinder Dhaliwal (email:
balvinder.dhali...@manchester.ac.uk).



   Regards,

   Balvinder.

[ccp4bb] PhD Studentship in Crystallography at the University of leeds

[Stephen Muench]

Dear all,

 Applications are invited for an EPSRC CASE award in membrane protein 
crystallography and electron microscopy. 

This PhD, funded by Pfizer Neusentis and an EPSRC CASE award, will use a 
multidisciplinary approach to study membrane ion channels important for human 
health and disease. This project will primarily be focused on X-ray 
crystallography and will take advantage of the recent £900,000 upgrade to the 
crystallization facility at the University of Leeds. In addition, single 
particle cryo electron microscopy will also be used, where appropriate, to 
obtain mechanistic information using new technologies developed at Leeds. The 
structural and mechanistic information obtained will lead into a structure 
based inhibitor design program. This project will allow the successful 
candidate to work in a multi-disciplinary field using cutting edge 
technologies. 

The demanding nature of this project means we are seeking highly motivated Ph.D 
candidates with an M.Sc./Bsc in biochemistry, molecular biology or a related 
discipline and a strong interest in structure-function studies on proteins. 
Experience of protein overexpression, purification, crystallization or membrane 
proteins is desirable but not essential. For informal enquiries and more 
details please contact Dr Stephen Muench (s.p.mue...@leeds.ac.uk), Dr Jonathan 
Lippiat ( j.d.lipp...@leeds.ac.uk ) or Prof. Adrian Goldman 
(a.gold...@leeds.ac.uk). 

For applications please visit; 
https://studentservices.leeds.ac.uk/pls/banprod/bwskalog_uol.P_DispLoginNon


Applicants must have an undergraduate- (minimum of 2:1, or equivalent) or 
masters-level degree in a related subject and must be UK or EU citizens (EU 
citizens must of resided within the UK for a minimum of 3 years to be eligible 
for the full stipend). The position will start in October 2014 and the closing 
date for applications will be 6th June.

Best wishes,

Stephen



Dr Stephen Muench
School of Biomedical Sciences
University of Leeds
Leeds
LS2 9JT
+44(0) 113 3434279

[ccp4bb] PhD Studentship at UCL

[Alun R Coker]

Dear All,

I'd like to draw your attention to the following PhD studentship.
http://www.findaphd.com/search/ProjectDetails.aspx?PJID=53965
Crystallography will form a large part of the project.

The deadline for applications is tomorrow Thursday April 10th.

Alun

--
Alun R. Coker
Senior Lecturer
Centre for Amyloidosis and Acute Phase Proteins
Division of Medicine (Royal Free Campus)
University College London
Rowland Hill Street
London
NW32PF

Tel: +44(0)20 7433 2764
Fax: +44(0)20 7433 2776
Web: www.ucl.ac.uk/pxmed

[ccp4bb] PhD studentship opportunities in Leeds

[Thomas Edwards]

Dear BB,

If you are, or know, a keen, talented, motivated student looking for a PhD, 
then there are several opportunities within the Faculty of Biological Sciences 
at the University of Leeds.
One project involves the use of stapled peptides to investigate inhibition of 
protein-protein interactions in cancer development and progression, another 
will look at Structure based drug design of anti vitals against a Hemorrhagic 
Fever Virus.
See:
http://www.fbs.leeds.ac.uk/staff/tae/EPSRC_Advert_JB_TE_RF.pdf
http://www.fbs.leeds.ac.uk/staff/tae/EPSRC_Advert_TAE_AJW.pdf
For more info. The deadline is short (20th Feb), appointments will be 
competitive,and the student must be in place at Leeds by April…

Email me with informal enquiries.

Ed

T.A.Edwards Ph.D.
Deputy Director Astbury Centre for Structural Molecular Biology
Ass. Professor, School of Molecular and Cellular Biology
Garstang 8.53d
University of Leeds, Leeds, LS2 9JT
Telephone: 0113 343 3031
http://www.fbs.leeds.ac.uk/staff/tae/
http://www.astbury.leeds.ac.uk/people/staff/staffpage.php?StaffID=TE
http://www.fbs.leeds.ac.uk/staff/profile.php?un=bmbtae
--You can't possibly be a scientist if you mind people thinking that you're a 
fool. - Wonko the Sane

[ccp4bb] PhD studentship

[A. Jeyaprakash Arulanandam]

Dear Colleagues,

A three year Wellcome Trust funded PhD studentship has recently become 
available at the Wellcome Trust Centre for Cell Biology (www.wcb.ed.ac.uk). The 
successful candidate will join students in the second year of the Wellcome 
Trust Four Year PhD Programme in Cell Biology.
 Qualifications required:
BSc with first or upper second class honours (or equivalent) in a relevant 
subject
MSc by Research in a cell biology related discipline
A good knowledge of spoken and written English
 This position is only available to UK and EU citizens due to funding 
restrictions.   A generous stipend, research costs and tuition fees (at the 
home/EU rate) are provided. Funds will also be available for travel and 
training. 
Suitably qualified applicants should submit an application form, CV and ask 
referees to send two references to Karen Traill (karen.tra...@ed.ac.uk) by 11 
November.

Applicants are required to nominate a PhD project supervisor.  Suitable 
applicants interested in pursuing PhD towards understanding the molecular 
mechanisms of accurate cell division using structural and cell biological 
methods are welcome to contact me (ajeya...@staffmail.ed.ac.uk, 
http://jeyaprakash.bio.ed.ac.uk) to discuss possible projects. 

With best wishes,
JP Arulanandam

Dr. A. Jeyaprakash Arulanandam
Wellcome Trust Centre for Cell Biology 
University of Edinburgh
Michael Swann Building
King's Buildings
Mayfield Road
Edinburgh EH9 3JR
Tel: +44 131 6507113
Web: http://jeyaprakash.bio.ed.ac.uk/

The University of Edinburgh is a charitable body, registered in
Scotland, with registration number SC005336.

[ccp4bb] PhD studentship in Biological Image Analysis

[Alun Ashton]

(Full details at http://www.nottingham.ac.uk/jobs/currentvacancies/ref/SCI1278)

Applications are invited for a fully-funded PhD studentship to be held jointly 
at the School of Computer Science, University of Nottingham and The Diamond 
Light Source, the UK's national synchrotron facility at Harwell, Oxfordshire. 
Diamond generates brilliant beams of light from infra-red to X-rays which are 
used to acquire images at extremely high resolutions: imaging of sub-cellular 
components of biological objects is a key application of the Diamond facility. 
Analysis of such images requires cell components to be identified and accurate, 
quantitative descriptions of their properties (shape, size, position, etc) 
recovered from the image. The very high spatial and grey-level resolution of 
synchrotron images means that very fine details (of e.g. mitochondria) are 
visible - organelles do not appear as simple, evenly coloured regions but as 
highly variable, textured areas. This PhD project seeks to develop automatic 
image analysis methods and software tools that can extract quantitative 
measurements of sub-cellular objects from Diamond Light images. The successful 
student will work closely with research staff and potential users at both 
Nottingham and Diamond.
 
Students should have a good first degree (preferably at the level of a 
first-class degree in the UK context) in Computer Science or a related 
discipline. Previous experience of image analysis, computer vision or 
biological science are an advantage, but not essential. 
 
Informal enquiries may be addressed to:
 Dr Andrew French: andrew.p.french @ nottingham.ac.uk
 Dr Mark Basham: Mark.Basham @ diamond.ac.uk
 Dr Tony Pridmore: tony.pridmore @ nottingham.ac.uk
 
Details on how to apply are on the website. 

Alun Ashton
___
Alun Ashton, alun.ash...@diamond.ac.uk Tel: +44 1235 778404
Group Leader - Data Analysis Software,www.diamond.ac.uk 
Diamond Light Source, Chilton, Didcot, Oxon, OX11 0DE, U.K.





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[ccp4bb] PhD studentship at Oxford Brookes University, Oxford

[Victor Bolanos-Garcia]

Dear Colleagues,

A competitive three year PhD studentship is available to work at
Oxford Brookes University on a multidisciplinary project aiming to
characterise novel interactions that regulate the accurate
and timely segregation of the genetic material upon cell division. The
project will foster skills in protein biochemistry, biophysics and
bioinformatics; molecular genetic manipulation; protein
overproduction, purification and structure characterisation.

The appointed individual will have the opportunity to train
undergraduate students in molecular biology, biochemical and
biophysical techniques; to regularly disseminate her/his work at
national and international meetings and to participate in outreach
activities such as Science Festivals and talks in schools.

Full details can be found at:
 http://www.findaphd.com/search/ProjectDetails.aspx?PJID=44082LID=1231
http://www.findaphd.com/search/ProjectDetails.aspx?PJID=44082LID=1231

Please note that Home, EU and international students are eligible to apply.

With best regards,

Victor M. Bolanos-Garcia

Faculty of Health and Life Sciences
Oxford Brookes University
Oxford, England

vbolanos-gar...@brookes.ac.uk

 

[ccp4bb] PhD studentship at UoLiverpool/CICbioGUNE

[Mayans, Olga]

Dear Colleagues, 

We are offering an exciting PhD studentship on the structural biology of RNA 
degradation and translational repression. The project combines state-of-the-art 
technologies in cryo-electron microscopy and X-ray crystallography and is a 
collaboration between the Spanish research institute CICbioGUNE in Bilbao and 
the University of Liverpool. The studentship covers approximately two years of 
research at each institute. If you are aware of high-calibre candidates who 
might be interested, please bring this opportunity to their attention. 

Full details can be found at:
 http://www.findaphd.com/search/ProjectDetails.aspx?PJID=41553LID=829 

Please note that this studentship is only available to EU/UK students. 

With best regards, 

U of Liverpool
Mark Caddick  Olga Mayans (cadd...@liv.ac.uk)

CICbioGUNE
Sean Connell  Paola Fuccini (sconn...@cicbiogune.es)

[ccp4bb] PhD studentship

[Laura Spagnolo]

Dear Colleagues,

I would like to draw the attention of interested students to this opportunity 
to perform a PhD in my laboratory:
http://www.findaphd.com/search/ProjectDetails.aspx?PJID=41839LID=456

The deadline for applications is 18.01.2013.

Best regards,
Laura



Dr Laura Spagnolo
Institute of Structural Molecular Biology
University of Edinburgh
Room 506, Darwin Building 
King's Buildings Campus
Edinburgh EH9 3JR
United Kingdom
T: +44 (0)131 650 7066 
F: +44 (0)131 650 8650 
http://www.biology.ed.ac.uk/research/institutes/structure/homepage.php?id=lspagnolo
laura.spagn...@ed.ac.uk










-- 
The University of Edinburgh is a charitable body, registered in
Scotland, with registration number SC005336.

[ccp4bb] PhD Studentship in Dundee, UK

[Paul Fyfe]

A PhD studentship is available in Dundee to work in the laboratory of Bill 
Hunter. The project involves the application of crystallographic methods to 
support early stage drug discovery targeting bacterial pathogens. A series of 
targets are available and the student will be engaged in protein purification, 
structural studies and the application of screening methods to search out novel 
ligands and inhibitors. The lab in Dundee is well equipped for all aspects of 
the research. Some experience with membrane bound proteins would be an 
advantage.

The funding, which is available immediately, can only support a student holding 
a european passport and an honours degree,  first or upper second, in a 
relevant subject. Please send a copy of your cv, names and contact details of 
three referees to Bill hunter 
(w.n.hun...@dundee.ac.ukmailto:w.n.hun...@dundee.ac.uk).

The University of Dundee is a registered Scottish Charity, No: SC015096

[ccp4bb] PhD Studentship at the University of Cambridge: Chemical Probes of Protein-Protein Interactions

[Alessio Ciulli]

A 3.5 years PhD studentship is available from October 2012 in the group led
by Dr Alessio Ciulli to design and develop novel small molecule chemical
probes that target protein interfaces that recognise post-translational
modifications of protein amino acids. This multi-disciplinary project will
combine molecular/structural biology and biophysical studies of
protein-protein complexes with small molecule drug design and organic
synthesis. For a recent example of our approach see Buckley et al. *J. Am.
Chem. Soc.*, *2012*, *134* (10), pp 4465–4468 (
http://pubs.acs.org/doi/abs/10.1021/ja209924v).

Applicants should have (or expect to obtain) at least the equivalent of a
UK II.1 honours degree (and preferably a Masters) in chemistry,
biochemistry, chemical biology, structural biology or other relevant
discipline. Applications from students with either a strong chemical or
biological science background are encouraged, where the applicant is
interested in learning the other discipline. The studentship will cover
tuition fees and a maintenance grant for EU nationals who satisfy the
eligibility requirements of the UK Research Councils. Owing to funding
restrictions, the studentship is not available to non-EU nationals.


Informal enquiries about the post can be sent to Dr Alessio Ciulli at

ac...@cam.ac.uk

Closing Date: 31 March 2012

Information on how to apply:
http://www.jobs.cam.ac.uk/job/-14772/http://www.jobs.cam.ac.uk/job/-14591/


best wishes,

Alessio

[ccp4bb] PhD studentship opportunity in Newcastle University

[Paula Salgado]

BBSRC MRes/PhD Studentship: Structural studies of biofilm-associated
proteins from human pathogens

4 Years (MRes Medical and Molecular Biosciences followed by a
three-year PhD) or 3 Years PhD, depending on qualifications, funded by
Faculty of Medical Sciences and BBSRC at the UK/EU rate.

This project is focused on the characterisation of proteins associated
with biofilm formation in the fungus Candida albicans and the
Gram-positive bacterium Clostridium difficile. The project will
involve protein expression, purification and structural determination
via protein X-ray crystallography, combined with other structural and
biochemical methods.

The successful candidate should have an undergraduate degree awarded
at an upper second or higher (or equivalent) in Biochemistry,
Chemistry, Molecular Biology or related subject (for 4 year programme)
or a Masters degree (for 3 year programme). Equivalent experience will
also be considered.

Candidates must complete the University's postgraduate application
form. http://www.ncl.ac.uk/postgraduate/apply/

Form more details, please see:

http://www.ncl.ac.uk/postgraduate/funding/search/list/cb071

or contact me via this email.


Best regards

Dr Paula Salgado

[ccp4bb] PhD studentship in Terahertz Spectroscopy

[Richard Pickersgill]

We are looking for an outstanding PhD student to apply Terahertz  
Spectroscopy to the study of protein librations and folding.


The studentship is funded at the standard research council rate for 3  
years. A first class or upper second class degree (or equivalent) is  
essential. For further details contact Robert Donnan  
robert.don...@eecs.qmul.ac.uk or myself. To apply, please email your  
cv to r.w.pickersg...@qmul.ac.uk (please put ?terahertz PhD? on the  
subject line); applications will be accepted until the 15th October  
and we should like to start this studentship January 2012 or earlier.


Richard W Pickersgill
Professor of Structural Biology
School of Biological and Chemical Sciences
Queen Mary University of London
London E1 4NS
England

Telephone 02078828444

[ccp4bb] PhD studentship in Structural Molecular Biology at Leeds Oct 2011

[Thomas Edwards]

Dear BB,

Please forward to any potential PhD applicants.

Thanks
Ed



PhD studentship in Structural Molecular Biology in collaboration with 
AstraZeneca.
Part of an integrated approach to discovering cell-permeable inhibitors of 
alpha helix-mediated protein-protein
interactions.

See
http://www.bmb.leeds.ac.uk/staff/tae/AZ_Studentship_inStrucBiol_Ad.pdf
For details.


Supervisory team:
Dr Thomas Edwards, Dr Andy Wilson, Professor Adam Nelson and Dr Stuart Warriner.

Protein−protein interactions (PPIs) mediate many biological mechanisms,
and, potentially, represent exciting targets for the treatment of disease.
Although small molecule inhibitors of a few PPIs have been discovered,
the principles that underpin the discovery of such ligands, within the
boundaries of drug-like chemical space, are much less well established
than for conventional medicinal chemistry targets such as enzymes and
receptors. In addition, it is unlikely, for example, that current small
molecule collections are honed for screening against PPIs.
We will target three contrasting α-helix mediated PPIs of strategic interest
to AZ. The proposed programme will integrate the combined expertise of
the team at Leeds (and our collaborators at AZ) in the synthesis of both
helix mimetics, and small molecules of unprecedented scaffold diversity,
in combination with cutting edge structural biology.

The studentship will start by October 1st 2011 and the stipend
would be at the standard research council rate (~ £13,895 pa
for 2011/12). Applications, for this 3.5 year studentship which
will be accepted until the studentship is filled, should be
directed to Anna Luty, School of Chemistry, University of Leeds, Leeds LS2 9JT 
and can be made
online via the following link: 
http://www.chem.leeds.ac.uk/postgraduate-research/how-to-apply.html

Please contact Dr Thomas Edwards (t.a.edwa...@leeds.ac.uk) or Dr. Andy Wilson
(a.j.wil...@leeds.ac.uk) for further details about this project.

UK Research Council eligibility rules apply.


__
T.Edwards Ph.D.
Garstang 8.53d
Astbury Centre for Structural Molecular Biology
University of Leeds, Leeds, LS2 9JT
Telephone: 0113 343 3031
http://www.bmb.leeds.ac.uk/staff/tae/
-- There is something fascinating about science.  One gets such wholesale 
returns of conjecture out of such a trifling investment of fact.  ~Mark Twain

[ccp4bb] PhD studentship in enzyme engineering at University of Reading

[Kimberly Ann Watson]

3-year PhD studentship available from October 2011

Department of Food and Nutritional Sciences and School of Biological Sciences

University of Reading



Project title: Optimisation of prebiotic galactooligosaccharide production 
through enzyme engineering



Project overview: Prebiotic oligosaccharides are compounds with potential 
health benefits, and as such have found various commercial applications as 
nutraceutical supplements or food ingredients. The aim of this project is to 
substantially improve the current process for the production of 
galactooligosaccharides (GOS), which involves the enzymatic synthesis of it 
from lactose using a b-galactosidase from Bifidobacterium, expressed in E. 
coli. The specific objectives of the project are to engineer the enzyme through 
site-directed mutagenesis and rational design in order to increase the 
production yields and the ratio of oligosaccharides with a high degree of 
polymerisation in the product mixture, and to optimise the fermentation and 
purification process for its production.



The PhD candidate will develop expertise in a range of techniques and 
methodologies including enzymology, protein engineering, protein expression, 
fermentation, purification, preparative and analytical chromatography.



Supervisors: Dr Dimitris Charalampopoulos (Department of Food and Nutritional 
Sciences), Dr Kim Watson (School of Biological Sciences)



Funding Details: Studentship will cover Home/EU Fees and pay the Research 
Council minimum stipend (£13,590 for 2010/11) per year for a period of up to 3 
years.



Eligibility: Applicants should hold a minimum of a UK Honours Degree at 2:1 
level or equivalent. Please note that due to restrictions on the funding, this 
studentship is for UK/EU applicants only.



How to apply: Eligible candidates should complete a University of Reading 
postgraduate application form available from 
http://www.reading.ac.uk/Study/apply/pg-applicationform.aspx. This should be 
submitted with supporting documents either to sc...@rdg.ac.uk or to:

Postgraduate Office Joint Faculty Office for Science and Life Sciences 
Geography Building University of Reading, PO Box 227 Reading, RG6 6AB



Application Deadline: Thursday, 31 March 2011



Further Enquiries: Informal enquiries may be addressed to Dr Dimitris 
Charalampopoulos d.charalampopou...@reading.ac.uk or Dr Kim Watson 
k.a.wat...@reading.ac.uk.

For application enquiries please contact Jonathan Lloyd j.d.ll...@reading.ac.uk
http://www.reading.ac.uk/research/res-pgr-degrees/FundingOpportunities/res-pgstudlife

[ccp4bb] PhD studentship in structural/cell biology at the University of Leicester

[Richard Bayliss]

A 3-year PhD studentship is available from October 2011 in the Biochemistry 
Department at the University of Leicester on Structural and functional studies 
on mitotic NIMA-related kinases. The student will be based jointly in the 
laboratories of Richard Bayliss (bayliss...@me.com) and Andrew Fry 
(a...@le.ac.uk), and informal enquiries can be sent to either supervisor. 
NIMA-related kinases are key regulators of mitosis, centrosomes and 
microtubules, and are a major focus of both laboratories. The Bayliss and Fry 
laboratories are housed within the flagship Henry Wellcome Building on the main 
University campus and are served by state-of-the-art facilities in structural 
biology and fluorescence microscopy. This project will provide the student with 
an excellent grounding in cutting-edge biochemical and molecular cell biology 
techniques. Hard-working, independent- minded and enthusiastic students who can 
work well in a team are encouraged to apply.

For examples of our recent work relevant to the project see:
1) Richards MW, O’Regan L, Mas-Droux C, Blot JMY, Cheung J, Hoelder S, Fry 
AM, Bayliss R. (2009) An auto-inhibitory tyrosine motif in the cell 
cycle-regulated Nek7 kinase is released through binding of Nek9. Mol. Cell. 
36(4):560-70. 
2)  O'Regan L, Fry AM. (2009). The Nek6 and Nek7 protein kinases are 
required for robust mitotic spindle formation and cytokinesis. Mol Cell Biol. 
29(14):3975-90. 

Project details:  
http://www2.le.ac.uk/colleges/medbiopsych/research/studentships/research-studentships-2011/MBSP-11-02%20Bayliss.pdf
Bayliss lab website: http://web.mac.com/baylisslab
Fry lab website: http://www2.le.ac.uk/departments/biochemistry/staff/fry
Departmental website: http://www2.le.ac.uk/departments/biochemistry/research

Eligibility: these awards are open to all applicants, but International  
applicants (i.e. non UK/EU nationals/permanent residents) will be required to 
pay the difference between the International Registration fee (approx £9,500 
p/a)

The Institute of Cancer Research: Royal Cancer Hospital, a charitable Company 
Limited by Guarantee, Registered in England under Company No. 534147 with its 
Registered Office at 123 Old Brompton Road, London SW7 3RP.

This e-mail message is confidential and for use by the addressee only.  If the 
message is received by anyone other than the addressee, please return the 
message to the sender by replying to it and then delete the message from your 
computer and network.

[ccp4bb] PhD studentship in biological EPR at the University of Edinburgh

[Janet Lovett]

Biological Structure Determination using Electron Paramagnetic Resonance

The 3 year project will investigate biomacromolecular structure using spin 
labelling and electron paramagnetic resonance (EPR) techniques.

The project will include involvement in all aspects of the study from molecular 
biology to EPR measurements and computer aided data analysis. You will be 
developing techniques to make them readily applicable to a range of biological 
problems by investigating real biological systems. Much of the work will be 
collaborative with groups from across the UK.

There is flexibility within the project for the student to concentrate on 
aspects they are particularly interested in but they will be encouraged to 
learn a range of skills from biochemistry to physics.

Candidates should expect to obtain an upper second or a first class (or 
equivalent) undergraduate degree in Chemistry, Biochemistry, Physics or a 
related subject.

Applications will be considered until the post is filled with the position 
starting Autumn 2011.

Please apply by sending a CV and the name of two referees to 
janet.lov...@ed.ac.uk

Please note that this is an EPSRC funded studentship and as such full funds are 
only available to residents of the UK though EU nationals are eligible to 
receive fees only (no living allowance). Please see 
http://www.epsrc.ac.uk/funding/students/Pages/eligibility.aspx before applying.

-- 
Dr Janet Lovett
Royal Society University Research Fellow
School of Chemistry, University of Edinburgh, EH9 3JJ
Tel: 0131 6504825
http://www.chem.ed.ac.uk/staff/academic/lovett.html
-- 

[ccp4bb] PhD studentship - Edinburgh, UK

[Laura Spagnolo]

A PhD studentship is available immediately in my laboratory at the  
University of Edinburgh.
Our studies focus on structural and biochemical studies of  
macromolecular complexes involved in the maintenance of genome  
stability. For more details, please refer to our website:

http://www.biology.ed.ac.uk/research/institutes/structure/homepage.php?id=lspagnolo

Informal enquiries are welcome. Interested candidates should email a  
CV and names of two referees to laura.spagn...@ed.ac.uk


Eligibility is restricted to UK citizens or EU citizens with 3 years  
residence in the UK.




--
Dr Laura Spagnolo
University of Edinburgh
Institute of Structural Molecular Biology
King's Buildings Campus
Darwin Building, Room 506
Mayfield Road
Edinburgh EH9 3JR
United Kingdom
T: +44 (0)131 650 7066
F: +44 (0)131 650 8650
http://www.biology.ed.ac.uk/research/institutes/structure/homepage.php?
id=lspagnolo



--
The University of Edinburgh is a charitable body, registered in
Scotland, with registration number SC005336.

[ccp4bb] PhD Studentship

[Malcolm Walkinshaw]

A  PhD studentship is available to work with Malcolm Walkinshaw  
(Edinburgh) and Jeremy Mottram (Glasgow) on the structure-based design  
of parasite inhibitors. The funding agency restricts applications to  
UK nationals.  Please contact m.walkins...@ed.ac.uk


--
Malcolm Walkinshaw
Chair of Structural Biochemistry
Institute of Structural and Molecular Biology
School of Biological Sciences
University of Edinburgh
Mayfield Rd
Edinburgh  EH9 3JR
Phone 0044 131 650 7056
http://ctcb.bio.ed.ac.uk/member_Malcolm.php

--
The University of Edinburgh is a charitable body, registered in
Scotland, with registration number SC005336.

[ccp4bb] PhD studentship (Paris region)

[Konrad Hinsen]

A three-year PhD studentship at the interface of molecular simulation  
and crystallography will be available at the University of Orléans,  
starting in October 2009. The research work will be done at the  
Synchrotron SOLEIL, 20 km from Paris.


Applicants should have a masters degree in physics or a related field  
and should have some experience in working with computers. Please  
send applicatons by e-mail, including a CV and a list of referees, to  
Konrad Hinsen hin...@cnrs-orleans.fr. The deadline for applications  
is June 15. For more information about the research group, see its  
Web site at http://dirac.cnrs-orleans.fr/.


Thesis subject:

Macromolecular crystallography is well known as a technique for  
obtaining the structure of biological macromolecules (proteins, DNA,  
RNA) and their complexes. However, it also provides information about  
the structural flexibility of these molecules, which remain barely  
exploited at the moment. The flexibility is of significant interest  
in biology because many biological processes depend on it. For  
example, an enzyme has to be flexible in order to adapt itself to the  
molecule whose chemical transformation it catalyzes.


In the diffraction images that are obtained when a macromolecular  
crystal is exposed to an X-ray beam, one can easily detect deviations  
from the theoretical images that would be obtained for a perfect  
crystal. These deviations are due partly to crystal defects, but also  
to the flexibility of the molecules. Traditionally, macromolecular  
crystallography concentrates on obtaining the molecular structure and  
eliminates in the course of data processing much of the information  
about flexibility and crystal defects. One reason for this is that  
the data quality used to be insufficient for a more detailed  
description of flexibility. A modern synchrotron light source is  
required for obtaining more precise images that permit an analysis of  
macromolecular flexibility.


The topic of the proposed thesis is the development of new methods  
for the interpretation of crystallographic data with the goal of  
separating crystal defects and flexibility and of characterizing the  
latter. These techniques will be based on molecular simulation, a  
method that is becoming increasingly important in the interpretation  
of experimental data. Molecular simulation makes it possible to  
describe a macromolecular crystal in more detail than the simpler  
models currently used in crystallography, at the price of a higher  
computational effort. In the course of the thesis work, the student  
will have the opportunity to acquire experience in molecular  
simulation, statistical physics, macromolecular crystallography, and  
scientific computing.

[ccp4bb] PhD studentship in structural biology, Max Planck, Gottingen

[Vlad Pena]

The position is available in the group of X-ray crystallography, Department
of Cellular Biochemistry (Prof. Reinhard Lührmann).

The project is part of the extensive effort of our department towards
understanding the structural basis of the spliceosome function. The
spliceosome is a multi-megadalton molecular machine which consists of over
150 proteins and a complex RNA network. This makes it one of the most
challenging crystallographic targets that can be imagined.

 

The activities will include recombinant protein isolation, biochemical
characterization, crystallization, structure determination and further
complementation by biochemical and genetic methods.

 

We have excellent labs for recombinant expression in E.coli and insect
cells, wet labs with various chromatography systems, state of the art
crystallization facilities, good computational infrastructure and easy
access to more synchrotron beamlines.

 

The applicant should have a MSc or a BSc diploma in biochemistry, biophysics
or related fields and some research experience in a laboratory.

Please send your application, including a CV and a list of referees to Dr.
Vlad Pena via e-mail (vp...@gwdg.de).

 

 

 

 

  .

Vlad Pena, PhD

Max Planck Institute for Biophysical Chemistry

Department of Cellular Biochemistry

X-Ray Crystallography

Am Fassberg 11, D-37077 Göttingen, Germany

Phone: +49 (0)551 201-1591

 

 

 

 

[ccp4bb] PhD studentship in structural biology, Cambridge, UK

[Leonid Sazanov]

Dear all, I will highly appreciate if the ad below is brought to the attention 
of 
students who may be interested. Thanks!

Applications are invited from recent graduates or final year undergraduates for 
the following PhD project in the MRC Mitochondrial Biology Unit, Cambridge, UK:

Structure of bacterial respiratory complex I

The aim of the project is to determine the crystal structure of respiratory 
complex I, which plays a central role in cellular energy production and is 
implicated in many human neurodegenerative diseases. We have determined 
the first X-ray structure of the catalytic core of this large molecular machine 
(Science 311, 1430-6 and Science 309, 771-4) and now aim to solve the 
structure of the entire complex by X-ray crystallography. 

This studentship will provide an excellent opportunity to gain broad experience 
in structural biology, X-ray crystallography and biochemistry. The Medical 
Research Council Mitochondrial Biology Unit is a leading international research 
centre that provides an opportunity for cutting-edge research. Facilities 
include a range of fermentors/chromatography systems for protein purification, 
electron microscopes, crystallisation robots and home X-ray sources. We have 
regular access to ESRF, SLS and Diamond synchrotrons. Our students are 
normally part of the Graduate School of Biological Sciences of Cambridge 
University and become members of one of the University colleges. The MRC 
studentship providing college fees and stipend (about £14500 pa subject to 
review) will be offered on a competitive basis subject to eligibility (EU 
citizens). The starting date is October 2009. 

Enquiries should be directed to Dr. L.A. Sazanov (saza...@mrc-
mbu.cam.ac.uk)
Full details are available at http://www.mrc-mbu.cam.ac.uk/

[ccp4bb] PhD studentship in Edinburgh

[Laura Spagnolo]

I am currently looking for a PhD student to work on structure/function  
studies of high-pressure adaptation by X-ray crystallography and  
electron microscopy coupled to single particle analysis. The research  
work will be carried out at the School of Biological Sciences (SBS)  
and at the Centre for Science at Extreme Conditions (CSEC) in  
Edinburgh. State-of-the art equipment for protein expression,  
purification and characterization and for high-pressure studies is  
available. Excellent X-ray crystallography facilities are also in  
place. The SBS has a strong interest in furthering its current  
electron microscopy resources.
Funding would be available for UK nationals or EU nationals with at  
least 3 years permanent residence in the UK.
Please contact Dr Laura Spagnolo (lspag...@staffmail.ed.ac.uk) for  
informal enquiries.

Best regards,
Laura


--
Dr Laura Spagnolo
Institute of Structural Molecular Biology
Room 702/705, Darwin Building
King's Buildings
Mayfield Road
University of Edinburgh
Edinburgh EH9 3JR
United Kingdom
T: +44 (0)131 650 7066
F: +44 (0)131 650 8650




--
The University of Edinburgh is a charitable body, registered in
Scotland, with registration number SC005336.

[ccp4bb] PhD studentship at the University of Exeter

[Harmer, Nicholas]

Dear CCP4-ers,

A PhD studentship in biochemistry and structural biology is available at the 
University of Exeter. The focus for this project will be toxin-antitoxin 
modules in the human pathogen Burkholderia pseudomallei, and their role in 
rendering bacteria resistant to antibiotics. The start date for the position is 
October 2009.

Further details of the position are available at: 
http://biosciences.exeter.ac.uk/postgraduate/newposts.php#disease

Please send informal enquiries to Professor Rick Titball 
(r.w.titb...@exeter.ac.ukmailto:r.w.titb...@exeter.ac.uk) or myself.

Best regards,

Nic Harmer

=
Dr. Nic Harmer
School of Biosciences
University of Exeter
tel: +44 1392 269179

[ccp4bb] PhD studentship at the MPL, Diamond

[Konstantinos Beis]

Dear All,
A PhD studentship at the Membrane Protein Lab (MPL) at Diamond Light  
Source (http://www.diamond.ac.uk/default.htm) is available  
immediately. The post will involve the structural determination by X- 
ray crystallography of membrane proteins from eukaryotic cells  
involved in various diseases and disorders. We have already cloned  
and performed initial purification of various proteins.



The MPL (http://www.diamond.ac.uk/Science/MPL/default.htm) is an  
Imperial College London outstation situated at the Diamond Light  
Source, outside Didcot. The state-of-the-art lab is fully equipped  
with purification systems and crystallisation robots for membrane  
proteins. It specialises in the structural determination of membrane  
proteins. Since the lab is part of Imperial College London, the  
student will have the opportunity to develop his/her academic  
knowledge by visiting the Department to attend courses and workshops.


The funding is only available to students who are eligible to receive  
a BBSRC studentship (http://www.bbsrc.ac.uk/funding/studentships/ 
index.html) and must meet the residency criteria.



The candidate must have a First class or 2:1 BSc or equivalent in a  
subject of Biochemistry or Molecular Biology.


Potential students can contact me to discuss the project in more detail.

To apply please send a cover letter and a CV with contact details of  
two referees to Dr Konstantinos Beis at [EMAIL PROTECTED]




Best,

Kostas





Dr. Konstantinos Beis   
RCUK Research Fellow
MPC group, Wolfson Lab, Level 1
Biochemistry Building
South Kensington Campus
Imperial College London
Exhibition Road
London SW7 2AZ
UK

Tel:  +44(0)20 7594 1873
 +44(0)20 7594 3173
Fax: +44(0)20 7594 3022


url:  http://www3.imperial.ac.uk/people/konstantinos.beis

url2: http://www.diamond.ac.uk/Science/MPL/default.htm


Or:

Membrane Protein Lab
Diamond Light Source
Harwell Science and Innovation Campus
Chilton, Didcot
Oxfordshire
OX11 0DE
UK

tel:  01235778413
fax: 01235778785

P Please consider the environment before printing this email

[ccp4bb] Phd studentship in structural biology and biophysics

[Remy Loris]

A Phd studentship is available in the group of Prof. Remy Loris to work 
on the structural biology and biophysics of the MazEF toxin-antitoxin 
module from Staphylococcus aureus. The project centres around crystal 
structure determination of the MazEF module and its complexes, 
interaction studies using a variety of biophysical techniques and, in 
collaboration with Prof. Ambrose Cheung (Dartmouth Medical School, USA), 
the development of small molecule drugs that interfere with the 
interaction between MazE and MazF.


Further information concerning bacterial toxin-antitoxin modules can be 
found in Buts et al. (2005) Toxin-antitoxin modules as bacterial 
metabolic stress managers. Trends Brioche. Sci. 30(12), 672-679.


Enquiries can be send to Prof. Remy Loris ([EMAIL PROTECTED]). Please 
attach a recent CV and the names of at least two referents.


Remy Loris
Vrije Universiteit Brussel
http://www.vib.be/
http://www.structuralbiology.be/

[ccp4bb] PhD Studentship in Structural Biology of Metalloproteins

[Hough, MA (Michael)]

A PhD studentship is available immediately at the University of Liverpool. 


Ph.D. in Structural Biology of Metalloproteins

Project: Structure based insights and interventions into SOD1-related motor 
neuron disease

Stipend: £13,000 per annum

More than 100 mutations of Cu-Zn superoxide dismutase (SOD1) are associated 
with the
familial form of amyotrophic lateral sclerosis (ALS), a disorder affecting the 
integrity of
motor neurons in the brain and spinal cord and leading to paralysis and death, 
usually within 5
years. While health care providers can do a great deal to ease the discomfort 
and anxiety
experienced by ALS patients, there is no known cure. The SOD1-linked sub-set of 
the disease
offers the best chance of understanding its origin and arriving at a general 
strategy for a cure.
Current research strongly suggests that the gain of a toxic property by this 
otherwise essential
enzyme is the cause of its pathogenic properties.

We are pursuing an intensive program that involves both computational and 
experimental
approaches based on structural data. Our main objective is to reveal the common 
structural
factors that make the mutations of the SOD1 molecule so lethal compared to the 
wild-type
enzyme, with the aim of stabilising the structures of pathogenic variants via a 
structure based
lead optimisation programme.

The Ph.D. studentship is jointly funded by the University and a small US 
biotech company. The
successful candidate will use a multidisciplinary approach based on X-ray 
crystallography, Xray
scattering and molecular biology methods. The project will be important for the 
future
development of therapeutic remedies for the familial form of the disease and 
will have wider
implications for the more common sporadic motor neuron disease as well as 
possibly other
neurodegenerative disorders such as Parkinson's and Alzheimer's diseases. We 
are looking for
candidates with strong motivation and interest in applying biophysical methods 
to important
biological problems. A background in molecular biology or biochemistry is 
desirable.

Funding Notes
Review of applications will begin immediately till a suitable candidate is 
found. You will need
to be a citizen of the European Union. Funding is available for an immediate 
start.

MBG web page: www.biophysics.dl.ac.uk

Elam JS, Taylor AB, Strange R, Antonyuk S, Doucette PA, Rodriguez JA, Hasnain 
SS,
Hayward LJ, Valentine JS, Yeates TO, et al.: Amyloid-like filaments and 
water-filled
nanotubes formed by SOD1 mutant proteins linked to familial ALS. Nature Struct. 
Biol. 2003,
10:461-467.
Hough MA, Grossman JG, Antonyuk SV, Strange RW, Doucette PA, Roderiguez J, 
Whitson
LJ, Hart P, Haywood LJ, Valentine JS, et al.: Destabilisation of the Dimer 
Interface in SOD1
may result in disease causing properties: Structures of motor neuron disease 
mutants A4V and
I113T. Proc. Natl. Acad. Sci. USA 2004, 101:5976-5981.
Strange RW, Antonyuk S, Hough MA, Doucette PA, Valentine JS, Hasnain SS: 
Variable
metallation of human superoxide dismutase: atomic and high-resolution crystal 
structures of
Cu-Zn, Zn-Zn and 'as isolated' wild-type enzymes. J. Mol. Biol. 2006, 
356:1152-1162.
Strange RW, Yong C, Smith WL, Hasnain SS: Molecular dynamics using 
atomic-resolution
structure reveal structural fluctuations that may lead to polymerization of 
human Cu-Zn
superoxide dismutase. Proc. Natl. Acad. Sci. USA 2007, 104:10040-10044.

For informal inquiries please contact 
Dr. Richard Strange (01925 603658; email: [EMAIL PROTECTED]) 
or Prof. S. Samar Hasnain (01925 603273; email: [EMAIL PROTECTED]).

[ccp4bb] PhD studentship available

[Dr Norbert Krauss]

Dear Colleague,

A BBSRC PhD studentship (for UK students only - EU students may be  
eligible for funding) is available for three years from October 2008  
to work in my laboratory at Queen Mary, University of London.


A provisional project title is Conformational changes during the  
photocycle of a bacterial phytochrome. Further information is  
available from


http://photosynthesis.sbcs.qmul.ac.uk/Krauss_PhDProject.pdf

The main requirement is for a motivated and qualified scientist with a  
commitment to solving important biological problems by means of  
structural analysis, including X-ray crystallography.


Please bring this opportunity to the attention of any interested  
graduate or final-year undergraduate in your research group or  
department.


Applicants are invited to apply at the earliest opportunity. The  
position is open until filled.


Best wishes,

Norbert Krauß

___

Dr Norbert Krauss
Senior Lecturer in Structural Biology

School of Biological and Chemical Sciences
Queen Mary, University of London
Walter Besant Building
Mile End Road
London E1 4NS
UK

Tel.:+44 20 7882 8445
e-mail:  [EMAIL PROTECTED]
http://www.sbcs.qmul.ac.uk/people/norbert_krauss.shtml
http://photosynthesis.sbcs.qmul.ac.uk/

[ccp4bb] PhD Studentship in Structure-based drug design

[Ruth Brenk]

SULSA PhD Studentship in Structure-based Drug Design / Molecular 
Modeling / X-ray crystallography: Structure-based design of 6PGDH 
inhibitors, a target for African sleeping sickness


A fully-funded PhD project in the University of Dundee / School of Life 
Sciences in the group of Dr. Ruth Brenk is now available. The project is 
a funded by SULSA and a collaboration with Ian Gilbert (University of 
Dundee) and Mike Barett (University of Glasgow).


Human African trypanosomiasis is a disease with an urgent need for the 
development of better drugs. A promising target is 6-phosphogluconate 
dehydrogenase (6PGDH) which has been validated genetically and 
chemically. Potent substrate-like inhibitors have been synthesised but 
they suffer from a lack of in vitro antiparasitic activity This is 
probably due to the high polarity of these compounds. Consequently, 
various phosphate prodrugs have been investigated and two trypanocidal 
compounds where identified. Despite these promising results stability 
issues remain. An alternative approach is to develop compounds with 
better intrinsic drug-like properties. The available crystallographic 
data enables a structure-based design approach to achieve this goal. An 
initial virtual screening has been carried out and a variety of 
inhibitors has been identified. The project aims to characterize these 
hits in terms of determination of inhibition constants for parasitic and 
human 6PGDH and determination of binding modes by use of X-ray 
crystallography. Based on these results more potent analogues will be 
designed.


This project will expose the student to a wide range of methods (protein 
purification, crystallisation, crystal structure analysis, enzyme 
kinetics, structure-based design, synthesis planning) and would fit a 
student with a background in the area of life sciences and a strong 
interest in protein-ligand interactions.


The 5* research rated School comprises 70 Research Groups and 700 staff 
from 51 countries. Dundee, set on the east coast of Scotland, lies in an 
area of outstanding natural beauty, including large sandy beaches and 
challenging hills. Rainfall charts show this is one of the most sunny  
dry places in the UK.


Further details are available from Dr. Ruth Brenk ([EMAIL PROTECTED], 
+44 (0)1382 386230).


To apply, please send a CV and details of at least two referees to Gail 
Guild

([EMAIL PROTECTED]), Postgraduate Administrator, School of Life Sciences,
MSI/WTB Complex, University of Dundee, Dow Street, Dundee DD1 5EH.
The starting date is flexible.

--
Dr. Ruth Brenk
Biological Chemistry and Molecular Microbiology
School of Life Sciences
University of Dundee
Dow St.
Dundee, DD1 5EH
U.K.
+44 (0)1382 386230 (phone)
+44 (0)1382 386373 (fax)
http://www.brenkgroup.dundee.ac.uk
http://www.dundee.ac.uk/biocentre/SLSBDIV1rb.htm

[ccp4bb] PhD studentship in structural biology

[Andrew Sutherland-Smith]

Dear CCP4 list,

We have a PhD studentship funded by a New Zealand Royal Society  
Marsden Grant  for three years to investigate the structure,   
functional properties and regulation of an enzyme hypothesised to be  
important for cellular responses to hypoxia and/or low glucose  
concentrations, with implications for cancer and ischemic disease.  
The project is a collaboration between AgResearch and Massey  
University  Palmerston North, New Zealand and the University of  
Auckland. The student will be based at Massey University.


Further details can be obtained from the link on the page http:// 
imbs.massey.ac.nz/opportunities/opportunities.htm or emailing me at  
the address below. Interested students should have obtained (or  
expect to) a good BSc honours or masters degree in an appropriate  
discipline and are encouraged to apply immediately.


Thanks
Andrew

Dr Andrew Sutherland-Smith
Institute of Molecular BioSciences
Massey University
Private Bag 11222
Palmerston North
New Zealand

Phone: +6463569099 x2578
Fax:  +6463505688
[EMAIL PROTECTED]

[ccp4bb] PhD studentship at University of Groningen, the Netherlands

[Andy-Mark Thunnissen]

A position for a PhD student is available at the University of Groningen 
to study the structure and function of proteins involved in sex pilin 
biosynthesis. The research will be conducted in the groups of Dr. 
Thunnissen (Laboratory of Biophysical Chemistry) and Dr. van der Does 
(Department of Molecular Microbiology).


*Requirements:*
We seek a highly motivated and skilled researcher with a masters degree 
in microbiology, biochemistry, molecular biology or similar and a keen 
interest in protein structure and function. Knowledge and/or experience 
of some of the following areas will be advantageous: recombinant protein 
expression and purification, protein crystallization, structure 
determination and molecular modelling. The candidate should have 
excellent communication skills with good command of oral and written 
English.


*Conditions of employment:*
The University of Groningen offers an Ubbo-Emmius fellowship covering 
standard living expenses for a period of 4 years, which should lead to a 
PhD in Natural Sciences. Currently, the fellowship is only available for 
non-Dutch nationals. The position is available from November 2007.


*Information:*
A more detailed description of this PhD position may be found at 
http://www.rug.nl/gbb/jobopportunities/bursarypositions/index.
Further information can be obtained from Dr. Chris van der Does 
([EMAIL PROTECTED]) or Dr Andy-Mark Thunnissen 
([EMAIL PROTECTED])


Applications in the form of a full CV (including list of subjects taken 
plus your grades, publications, etc.) and the names, addresses and 
telephone/fax numbers of two academic referees should be sent by E-mail 
or fax to:  Dr. Andy-Mark Thunnissen, Laboratory of Biophysical 
Chemistry, University of Groningen, Nijenborgh 4, 9747 AG Groningen, the 
Netherlands, E-mail [EMAIL PROTECTED], fax +31.50.3634800



--
Dr. A.M.W.H. Thunnissen
Laboratory of Biophysical Chemistry, University of Groningen
Nijenborgh 4, 9747 AG Groningen, the Netherlands
Phone +31.50.3634380 Fax +31.50.3634800

[ccp4bb] PhD Studentship available for UK/EU residents

[Moody, Dr P.C.E.]

FULLY FUNDED STUDENTSHIP IN CHEMICAL BIOLOGY AVAILABLE FOR OCTOBER 2007

 

A fully funded PhD studentship is available for October 2007 start (to cover 
stipend, approx £13,000 per annum, and fees, approx £3000 per annum) in the 
area of chemical biology. It is a multidisciplinary project and will be jointly 
supervised by Professor Emma Raven 
http://www.le.ac.uk/chemistry/staff/el10.html  (Department of Chemistry) and 
Dr Peter Moody http://www.le.ac.uk/biochem/staff/pcem1/pcem1.html  
(Department of Biochemistry). The successful applicant will join an active 
collaborative research environment working at the chemistry/biology interface 
and the project will provide the successful applicant with an opportunity to 
interact with other biochemists and molecular biologists within the Centre for 
Chemical Biology http://www.le.ac.uk/chemistry/chembiol/  at Leicester. 

The project will be based in the new £22m Henry Wellcome Building for 
Biomedical Research and will involve an examination of transient catalytic 
intermediates in a heme-containing protein and will use structural, 
spectroscopic and kinetic techniques. There will be opportunities to interact 
with other groups in the Henry Wellcome Building and outside of Leicester, 
including frequent visits to synchrotron facilities in this country and abroad. 
You will be joining an active group of postdoctoral and postgraduate 
researchers working on various aspects of heme biochemistry and mechanism and 
will be exposed to a range of techniques and methodologies spanning the 
chemistry/biochemistry/molecular biology areas. The project would suit an 
ambitious individual looking to expand their expertise at the chemistry/biology 
interface. Prof Raven's and Dr Moody's laboratories are situated in the brand 
new £22m Henry Wellcome Building for Biomedical Research. We can offer 
state-of-the-art infrastructure to support your work and laboratories that are 
equipped to the highest standard. For further information on the range of 
activities on-going in both laboratories please visit the respective web sites 
(http://www.le.ac.uk/chemistry/staff/el10.html and  
http://www.le.ac.uk/biochem/staff/pcem1/pcem1.html 
http://www.le.ac.uk/biochem/staff/pcem1/pcem1.html ). 


How to apply 


Candidates should have, or expect to obtain, a first or upper second class 
degree in chemistry, biochemistry or a related discipline or equivalent. The 
position is open to UK or EU nationals. 

Interested applicants may contact Prof Emma Raven mailto:[EMAIL PROTECTED]  
or Dr Peter Moody mailto:[EMAIL PROTECTED]  for further information. To 
apply, please send CV plus details of two referees. 

 

 

 
Peter Moody
Henry Wellcome Laboratories of Structural Biology
Department of Biochemistry
Henry Wellcome Building
University of Leicester
LE1 9HN
0116 229 7097