Hi there,
another nice kinase example might be IRAK-4. there are several pdbs,
the one I have in mind is 2OIB. The alphaC helix that takes on
different conformations in active and inactive conformations in
kinases ('in' and 'out') is in four different positions in the four
different copies per asu. A side note is that in this particular
kinase, the helix-out conformation is the active conformation.
Baerbel
On Mon, Jan 27, 2014 at 10:08 AM, Shane Caldwell <shane.caldwel...@gmail.com
> wrote:
> Hi ccp4bb,
>
> I'm putting together a talk for some peers that highlights strengths and
> weaknesses of structural models for the outsider. For one point, I'd like
> to find some examples of proteins that show very different conformations
> between different copies in the ASU. One example I know of is
c-Abl (1OPL),
> which crystallizes with both autoinhibited and active forms in the ASU,
> with dramatically different domain organization. I'd like to find some
> additional examples - can anyone suggest some other structures that have
> multiple copies with large structural variations?
>
> Thanks in advance!
>
> Shane Caldwell
> McGill University
>
>
>
--
Bärbel Blaum, Ph.D.
Interfakultäres Institut für Biochemie (IFIB)
Hoppe-Seyler-Strasse 4
D-72076 Tübingen
Germany
+49 70 71 29 73 375
