Dear Shane, To add a bit of detail to Frank von Delft's suggestion, perhaps the best example is the structure of the yeast F1-ATPase that has 3 copies in the asu, from David Mueller's lab in Chicago. Two of these are very similar, but the third is rather different and shows a (physiologically relevant) phosphate binding site that is not found in the other two copies. I would not describe the differences as dramatic though.
The paper is: Kabaleeswaran et al., EMBO J 25, 5433 (2006) PDB ID 2HLD Best wishes, Andrew Leslie On 27 Jan 2014, at 18:08, Shane Caldwell <shane.caldwel...@gmail.com> wrote: > Hi ccp4bb, > > I'm putting together a talk for some peers that highlights strengths and > weaknesses of structural models for the outsider. For one point, I'd like to > find some examples of proteins that show very different conformations between > different copies in the ASU. One example I know of is c-Abl (1OPL), which > crystallizes with both autoinhibited and active forms in the ASU, with > dramatically different domain organization. I'd like to find some additional > examples - can anyone suggest some other structures that have multiple copies > with large structural variations? > > Thanks in advance! > > Shane Caldwell > McGill University > >