Another interesting example might be a structure of Mad2, protein essential in the process of chromosome segregation. Protein has 2 different secondary structure topologies and both of them are part of the AU in 2V64. There are other X-ray structures where only one of the conformations is captured in the crystal.
Good luck, Nikolina Nikolina Sekulic, PhD Research Associate Department of Biochemistry and Biophysics University of Pennsylvania Stellar-Chance Laboratory 912 422 Curie Blvd, Philadelphia cell: 312-437-9095 lab: 215-898-4476 e-mail: seku...@mail.med.upenn.edu On Tue, Jan 28, 2014 at 8:26 AM, tamir gonen <tgonen...@gmail.com> wrote: > Hi Shane, > > One example that comes to mind is aquaporin-z. Two protomers were found in > the ASU, one contained the water channel in an open conformation while the > other in a closed conformation. The structural differences are not "large" > but the functional implication is. > > Here is the primary citation > > Architecture and selectivity in aquaporins: 2.5 a X-ray structure of > aquaporin Z. <http://www.ncbi.nlm.nih.gov/pubmed/14691544> > > *Savage* DF, Egea PF, Robles-Colmenares Y, O'Connell JD 3rd, *Stroud* RM. > > PLoS Biol. *2003* Dec;1(3):E72. Epub *2003* Dec 22. > > > Kind regards > Tamir > > ---- > gon...@hhmi.org > > > On Jan 27, 2014, at 1:08 PM, Shane Caldwell <shane.caldwel...@gmail.com> > wrote: > > Hi ccp4bb, > > I'm putting together a talk for some peers that highlights strengths and > weaknesses of structural models for the outsider. For one point, I'd like > to find some examples of proteins that show very different conformations > between different copies in the ASU. One example I know of is c-Abl (1OPL), > which crystallizes with both autoinhibited and active forms in the ASU, > with dramatically different domain organization. I'd like to find some > additional examples - can anyone suggest some other structures that have > multiple copies with large structural variations? > > Thanks in advance! > > Shane Caldwell > McGill University > > > >
