I will try to explain again and give you the benefit of the doubt once,
although I suspect it may just extend this conversation into the indefinite
What do you mean by ensuring security? Who is your oponent? What is the
threat? What are you trying to achieve?
I will divide this into two separate sections:
 *Regular Joe*
If I stop running Windows, format my harddrive, install Trisquel, and start
using Trisquel, can I not reasonably assume that Microsfot is now unable to
perform whatever abuses they used to be able to perform through their
proprietary operating system? Does that not apply to every other program?
Free software allows you to do your computing in freedom, by ensuring you
have four basic freedoms. These freedoms allow you to run the program as you
wish, to share it, to study how it works and change it, to share your changes
so others can benefit from them. These freedoms DO NOT guarantee that a
program will not be abusive or violate your privacy, etc., but it gives you
and others the possibility to detect it and to defend yourselves against
this. You, and all other users, can have control of the program.
I hope so far I have been clear. It is not an all or nothing deal. Assuming
that your system is potentially unsafe against an unknown adversary through
specter or meltdown or whatever else, is unrelated to whether you have an
abusive relationship with Microsoft through the Windows OS (in my example).
Likewise, I can easily stop most other owners of proprietary programs from
 *International Man of Mystery Joe*
By the sounds of it, you are trying to protect yourself against some sort of
powerful state actor. Further, you seem to believe this powerful oponent is
out to get YOU, targeting you specifically. Either this or you assume somehow
that this powerful oponent is somehow simultaneously exploiting all computer
users through spectre or meltdown or ME, or everything at once (??).
If you're worry is that you are being targetted by your local intelligence
agency or the NSA or something like that, really, my advise is to minimize
your use of computers for whatever it is that you want to keep private.
Further, I would speculate that operational security is much more important
than whether you've run ME cleaner on your computer (though I suppose it
wouldn't hurt either).
My guess is the Trisquel forum is not the ideal place to find a thorough
knowledge to evade such an adversary.
While I'll give you the benefit of the doubt as stated in point #2 (What do I
know, maybe you're Edward Snowden, though I hope not), for any other security
concern, you should really develop a threat model and mitigate against that.
There is no perfect security.
There is no total privacy.
There is no way to simultaneously defend yourself against all possible
threats all of the time and lead a functional life.