110.23442
11200.410F110.23442
11800.3510F110.23442
12400.1310F110.23442
Zheng
--
Nick Holford, Dept Pharmacology Clinical Pharmacology
University of Auckland, 85 Park Rd
it.
Steve
--
Professor Stephen Duffull
Chair of Clinical Pharmacy
School of Pharmacy
University of Otago
PO Box 913 Dunedin
New Zealand
E: [EMAIL PROTECTED]
P: +64 3 479 5044
F: +64 3 479 7034
Design software: www.winpopt.com
--
Nick Holford, Dept Pharmacology Clinical
3693
E-mail: [EMAIL PROTECTED]
--
Nick Holford, Dept Pharmacology Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand
email:[EMAIL PROTECTED] tel:+64(9)373-7599x86730 fax:373-7556
http://www.health.auckland.ac.nz/pharmacology/staff/nholford/
, if not NONMEM?
The question is asked because certain epidemic diseases are season-sensitive
and none assumption on base hazard is advantageous over parametric
approaches. Thank you in advance!
Liang Zhao
--
Nick Holford, Dept Pharmacology Clinical Pharmacology
University of Auckland, 85
Tyne,
NE2 4HH
Email: [EMAIL PROTECTED]
-Original Message-
From: [EMAIL PROTECTED] [mailto:[EMAIL PROTECTED] On Behalf Of Nick Holford
Sent: 03 July 2007 22:59
To: nmusers@globomaxnm.com
Subject: Re: [NMusers] COX Proportional
://tv.yahoo.com/collections/265
--
Nick Holford, Dept Pharmacology Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand
[EMAIL PROTECTED] tel:+64(9)373-7599x86730 fax:+64(9)373-7090
www.health.auckland.ac.nz/pharmacology/staff/nholford
Subject: Re: [NMusers] Minimization terminated ?
From: Nick Holford [EMAIL PROTECTED]
Date: Fri, July 20, 2007 5:04 pm
To: nmusers nmusers@globomaxnm.com
Navin,
NONMEM is quite unreliable when it comes to deciding if it has
converged. Minor changes
important. As an example, is
a volume estimate of 96.3 L that much better than 93 L.
--
Nick Holford, Dept Pharmacology Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand
[EMAIL PROTECTED] tel:+64(9)373-7599x86730 fax:+64(9)373-7090
. If you fix the bug with NP is there a situation where
this error message can occur?
Nick
--
Nick Holford, Dept Pharmacology Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand
[EMAIL PROTECTED] tel:+64(9)373-7599x86730 fax:+64(9)373-7090
of the current observation record.
Nick
--
Nick Holford, Dept Pharmacology Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand
[EMAIL PROTECTED] tel:+64(9)373-7599x86730 fax:+64(9)373-7090
www.health.auckland.ac.nz/pharmacology/staff/nholford
or knowledge of the nonmem code to be
more assertive. This is my
guess only, but guess confirmed by a special treatment of a time dependency
in the $MIX block (as
you described).
Leonid
Nick Holford wrote:
Leonid,
I dont see why a proportion should not change with time
MedImmune, Inc.
[EMAIL PROTECTED]
Phone: 301-398-5356
Fax: 301-398-8356
From: [EMAIL PROTECTED] on behalf of Nick Holford
Sent: Mon 7/30/2007 5:14 PM
To: nmusers
Subject: Re: [NMusers] $MIX and $CONTR
Leonid,
I dont see why a proportion should
description of your problem.
Leonid
Nick Holford wrote:
Leonid,
Thanks for your thoughtful comments.
I think there are two things to keep separate:
1. Imagine a drug response can be described by a bi-modal distribution when
one examines a sample of subjects who are all children
simulation) the DATA matrix does
not hold AGE as described, while with ICALL=2 it does; one may observe
this by removing the ONLYSIM option of the $SIMULATION record...
Best regards,
Erik
On Tue, 2007-07-31 at 16:10 +1200, Nick Holford wrote:
Leonid,
The model you propose is based
Hi,
Can someone give me some clues on how to sample from a multivariate normal
distribution using S-plus?
Some working code examples would be very helpful.
Thanks,
Nick
--
Nick Holford, Dept Pharmacology Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag 92019, Auckland
???)
Are there any other error models that could be used with the log
transformed data, apart from the
Y=Log(f)+EPS(1)
Any suggestions would be appreciated
--
--Navin
--
Nick Holford, Dept Pharmacology Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag 92019, Auckland
=VER1.TAB
$TABLE ID TIME IAGE K12 K21 K R1 IDIF NOPRINT FILE=VER1.TAB
$SCAT CP VS IPR1 UNIT
--
Nick Holford, Dept Pharmacology Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand
[EMAIL PROTECTED] tel:+64(9)373-7599x86730 fax:+64(9)373-7090
)*(WT/10.4)
V2 = TVV2*EXP(ETA(3))
TVQ = THETA(4)*(WT/10.4)**0.75
Q = TVQ
Thanks for all of your input - JM
Nick Holford [EMAIL PROTECTED] 10/25/2007 2:40:49 PM
Mark,
We have a different view of the big picture. Regulatory and marketing are
minor shadows
and marketing are minor shadows in
the big picture. If you can point to such evidence in the published literature
I am willing to be educated.
Nick
--
Nick Holford, Dept Pharmacology Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand
[EMAIL
on - beyond annoying! I
am using Windows. Does anyone know how to prevent this?
I saw in the archives that Mark Sale (I believe) asked this question many years
ago, but it did not appear that a satisfactory answer was returned.
Thanks in advance,
Dave
--
Nick Holford, Dept
are not the intended recipient, please contact the
author by reply email and destroy all original and copies of this email
message.
--
Nick Holford, Dept Pharmacology Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand
[EMAIL PROTECTED] tel:+64(9)373-7599x86730
#
# #
0 # #
--
Nick Holford, Dept Pharmacology Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand
[EMAIL PROTECTED] tel:+64(9)373-7599x86730 fax:+64(9)373-7090
www.health.auckland.ac.nz/pharmacology/staff/nholford
--
Nick Holford, Dept Pharmacology Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand
[EMAIL PROTECTED] tel:+64(9)373-7599x86730 fax:+64(9)373-7090
www.health.auckland.ac.nz/pharmacology/staff/nholford
: [EMAIL PROTECTED] [mailto:[EMAIL PROTECTED] On
Behalf Of Nick Holford
Sent: Friday, May 23, 2008 10:40 AM
To: nmusers@globomaxnm.com
Subject: Re: [NMusers] Visual predictive check!
Ken,
You wrote among other things:
The combined residual error model cannot be the correct model at very
low
Hospital Boston / Harvard Medical School
179 Longwood Ave, Boston, MA 02115
Phone: (617) 732-2905
Fax: (617) 732-2228
*From:* [EMAIL PROTECTED] on behalf of Ken Kowalski
*Sent:* Fri 5/23/2008 11:22 AM
*To:* 'Nick Holford
would like to hear your thoughts on this and any suggestions on how
to proceed with modeling combined data from pediatric and adult studies.
Regards,
- Chandra
--
Nick Holford, Dept Pharmacology Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand
be greatly appreciated.
Thanks!
Sincerely
--
Kelong Han
PhD student
--
Nick Holford, Dept Pharmacology Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand
[EMAIL PROTECTED] tel:+64(9)373-7599x86730 fax:+64(9)373-7090
www.health.auckland.ac.nz
NOPRINT FILE=ENCAP4 ONEHEADER
$SCAT (RES WRES) VS TIME BY ID
Best regards,
Huali
--
Nick Holford, Dept Pharmacology Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand
[EMAIL PROTECTED] tel:+64(9)373-7599x86730 fax:+64(9)373-7090
-associated allometric component)? Logically,
such a need seems to be not reasonable. How to deal with this
conflict? Is there an almost agreeable thought on this issue in
our community?
Thank you,
Hong-Guang
--
Nick Holford, Dept Pharmacology Clinical Pharmacology
to describe the PK parameters of a drug. To imagine
that clearance and volume are not related to weight is just foolish.
Nick
James G Wright wrote:
Nick Holford wrote:
Body weight is always important (in adults and children) even if the
data set you are studying is inadequate
appreciated! Thanks a lot!
Feng
--
Nick Holford, Dept Pharmacology Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand
[EMAIL PROTECTED] tel:+64(9)373-7599x86730 fax:+64(9)373-7090
http://www.fmhs.auckland.ac.nz/sms/pharmacology/holford
://www.bayerscheringpharma.de
Vorstand: Arthur J. Higgins, Vorsitzender | Werner Baumann, Andreas Busch,
Ulrich Köstlin, Kemal Malik, Gunnar Riemann
Vorsitzender des Aufsichtsrats: Werner Wenning
Sitz der Gesellschaft: Berlin | Eintragung: Amtsgericht Charlottenburg 93
HRB 283
--
Nick
the analysis?
Thanks in advance for any help given.
Paul Westwood,
PhD Student,
QUB,
Belfast.
--
Nick Holford, Dept Pharmacology Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand
[EMAIL PROTECTED] tel:+64(9)373-7599x86730 fax:+64(9)373-7090
Matthew Westwood wrote:
From: Paul Matthew Westwood
Sent: 22 July 2008 13:20
To: Nick Holford
Subject: RE: [NMusers] PPC
Nick,
Thanks for your reply and apologies once again for another confusing email. I
think I am using VPC, which as I understand
To: Nick Holford; nmusers@globomaxnm.com
Subject: RE: FW: [NMusers] PPC
Hi Nick,
I have been following this discussion and I think it is very helpful to
many of us. Can you please elaborate on that last part about binning?
What is that for? I must have missed something there.
Thanks,
Susan
PROTECTED] [mailto:[EMAIL PROTECTED] On
Behalf Of Nick Holford
Sent: Friday, July 25, 2008 2:12 AM
To: nmusers@globomaxnm.com
Subject: Re: FW: [NMusers] PPC
Mahesh,
Thanks for your further info on VPC and PPC. I agree that the bootstrap
distribution of the parameters is probably better than
advantageous.
Thanks, Mohamed
Quoting Nick Holford [EMAIL PROTECTED]:
--
Nick Holford, Dept Pharmacology Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand
[EMAIL PROTECTED] tel:+64(9)373-7599x86730 fax:+64(9)373-7090
http://www.fmhs.auckland.ac.nz
-Original Message-
From: [EMAIL PROTECTED] [mailto:[EMAIL PROTECTED] On
Behalf Of Nick Holford
Sent: Friday, July 25, 2008 5:14 PM
To: nmusers
Subject: Re: FW: [NMusers] PPC
Matt,
Thanks for your comments which I almost completely agree with.
You propose to log transform the parameters so
University of Bonn
Department of Clinical Pharmacy
An der Immenburg 4
D-53121 Bonn
phone:+49 228 73 5781
fax: +49 228 73 9757
--
Nick Holford, Dept Pharmacology Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand
[EMAIL PROTECTED] tel:+64(9)373
, M.S., Ph.D.
Animal Cancer Center
Veterinary Teaching Hospital
Colorado State University
300 West Drake Road
Fort Collins, CO 80523-1620
PHONE: (970) 219-7599
FAX: (970) 297-1254
EMAIL: [EMAIL PROTECTED]
--
Nick Holford, Dept Pharmacology Clinical Pharmacology
University of Auckland, 85 Park
***
--
Nick Holford, Dept Pharmacology Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand
[EMAIL PROTECTED] tel:+64(9)373-7599x86730 fax:+64(9)373-7090
http://www.fmhs.auckland.ac.nz/sms/pharmacology/holford
information about the compiler.
And maybe a silly question. Is there any difference between Compaq
Visual Fortran and Digital Visual Fortran?
Let me know your experience, and the reasons to base your selection.
Thank you in advance,
Mark
--
Nick Holford, Dept Pharmacology Clinical
]
-Original Message-
From: [EMAIL PROTECTED] [mailto:[EMAIL PROTECTED]
On Behalf Of Nick Holford
Sent: Monday, 08 September, 2008 17:12
To: nmusers
Subject: Re: [NMusers] NONMEM memory vs. run time
Leonid, Darin,
Here are some experimental results rather than theoretical predictions.
I ran a problem
for binary data?
3. Can the model results from CAUC be extrapolated to other trial
designs, why or why not?
Your input is appreciated. Thanks.
Yi Zhang
Centocor
--
Nick Holford, Dept Pharmacology Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand
comments.
Thank you very much again for your help.
All the best
Kuenhi
-Original Message-
From: Nick Holford [mailto:[EMAIL PROTECTED]
Sent: Monday, September 15, 2008 3:40 PM
To: Tsai, Kuenhi
Subject: Re: [NMusers] Revisit parameterization question
Kuenhi,
Parameterisation
a subcutaneous injection site?
Thank you for your thoughts,
Joachim
__
Joachim GREVEL, Ph.D.
MERCK SERONO International S.A.
Exploratory Medicine
1202 Geneva
Tel: +41.22.414.4751
Fax: +41.22.414.3059
Email: [EMAIL PROTECTED]
--
Nick Holford, Dept
$ERROR
CLIDO=A(1)/V1
CMEGX=A(3)/VMEGX
;You need to add DVID data item to your data set to identify which
records are LIDO and which are MEGX observations.
IF (DVID.EQ.1) THEN ; LIDO conc
Y=CLIDO*(1+ERR(1))
ELSE ; MEGX conc
Y=CMEGX*(1+ERR(2))
ENDIF
Best wishes,
Nick
Nick Holford wrote
request a hard-copy version. Merck
Serono does not guarantee that this message is free of viruses and
does
not accept liability for any damages caused by any virus transmitted
therewith.
--
Nick Holford, Dept Pharmacology Clinical Pharmacology
University
2327
Fax +44 (0) 114 292 2333
www.simcyp.com
real solutions from virtual populations
-Original Message-
From: [EMAIL PROTECTED] [mailto:[EMAIL PROTECTED] On
Behalf Of Nick Holford
Sent: 19 September 2008 23:11
To: nmusers
Subject: Re: [NMusers] Scaling for pediatric study planning
Masoud
based on which the parameters are estimated? And then the
predictions are made on the estimated parameters? A little confused.
Appreciate any comment.
Jun
--
Nick Holford, Dept Pharmacology Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand
[EMAIL
GlaxoSmithKline
1500 Littleton Road,
Parsippany, NJ 07054
Ph:9738892200
--
Nick Holford, Dept Pharmacology Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand
[EMAIL PROTECTED] tel:+64(9)923-6730 fax:+64(9)373-7090
http://www.fmhs.auckland.ac.nz/sms
differences by ANOVA vs
finding a demographic covariate tested by NONMEM.
Regards,
Ayyappa Chaturvedula
GlaxoSmithKline
1500 Littleton Road,
Parsippany, NJ 07054
Ph:9738892200
*Nick Holford [EMAIL PROTECTED]*
Sent by: [EMAIL PROTECTED]
16-Oct-2008 14:38
To
nmusers
,*) OBJECT
WRITE (52,*) THETA
WRITE (53,*) SETHET
WRITE (54,*) OMEGA(BLOCK)
WRITE (55,*) SEOMEG(BLOCK)
WRITE (56,*) SIGMA(BLOCK)
WRITE (57,*) SESIGM(BLOCK)
WRITE (58,*) IERE,IERC
ENDIF
On Tue, Oct 14, 2008 at 8:26 PM, Nick Holford
[EMAIL PROTECTED] mailto:[EMAIL
immediately by reply e-mail and
then delete it from your system.
--
Nick Holford, Dept Pharmacology Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand
[EMAIL PROTECTED] tel:+64(9)923-6730 fax:+64(9)373-7090
http://www.fmhs.auckland.ac.nz/sms
, please
request a hard-copy version. Merck Serono does not guarantee that this
message is free of viruses and does not accept liability for any damages
caused by any virus transmitted therewith.
--
Nick Holford, Dept Pharmacology Clinical Pharmacology
University of Auckland, 85 Park Rd
be handled differently from
theta, omega or sigma.
(Though I don't like the above criteria using chi-square distribution,)
I would like to know if there is similar quantitative criteria for IOV.
Thanks,
Kyun-Seop Bae
--
Nick Holford, Dept Pharmacology Clinical Pharmacology
University
Can any offer an original source reference for this well used phrase?
Pharmacokinetics is what the body does to the drug. Pharmacodynamics is
what the drug does to the body
Thanks,
Nick
--
Nick Holford, Dept Pharmacology Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag
PROTECTED]
[mailto:[EMAIL PROTECTED] Behalf Of Nick Holford
Sent: Thursday, November 13, 2008 1:58 PM
To: nmusers
Subject: Re: [NMusers] NONMEM message
Mitsuo,
This is a special kind of NONMEM error message:
MINIMIZATION SUCCESSFUL
HOWEVER, PROBLEMS OCCURRED WITH THE MINIMIZATION.
REGARD
with time (or
occasions). Adding a covariate that make physiological sense and also
decrease with time may help your modeling.
Best,
Xia
==
Xia Li
Mathematical Science Department
University of Cincinnati
--
Nick Holford, Dept Pharmacology Clinical Pharmacology
estimates.
-Original Message-
From: [EMAIL PROTECTED] [mailto:[EMAIL PROTECTED]
On Behalf Of Nick Holford
Sent: 14 November 2008 00:11
To: nmusers
Subject: Re: [NMusers] Very small P-Value for ETABAR
Jakob,
Thanks for some more info on this issue. I have seen work from Mats and
Rada
--
mail2web.com - Microsoft® Exchange solutions from a leading provider -
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Nick Holford, Dept Pharmacology Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand
[EMAIL PROTECTED] tel:+64(9)923-6730 fax:+64(9)373
difficulties in converge, do you stop here or would you use FO?
Thanks,
Alan
--
Nick Holford, Dept Pharmacology Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand
[EMAIL PROTECTED] tel:+64(9)923-6730 fax:+64(9)373-7090
http://www.fmhs.auckland.ac.nz
Registered number: 145835
--
Nick Holford, Dept Pharmacology Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand
[EMAIL PROTECTED] tel:+64(9)923-6730 fax:+64(9)373-7090
http://www.fmhs.auckland.ac.nz/sms/pharmacology/holford
here or would you use FO?
Thanks,
Alan
--
Nick Holford, Dept Pharmacology Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand
[EMAIL PROTECTED] tel:+64(9)923-6730 fax:+64(9)373-7090
http://www.fmhs.auckland.ac.nz/sms/pharmacology/holford
.
Thank You,
ICON plc
South County Business Park
Leopardstown
Dublin 18
Ireland
Registered number: 145835
--
Nick Holford, Dept Pharmacology Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand
[EMAIL PROTECTED] tel:+64(9)923-6730 fax:+64(9)373
G Wright PhD
Scientist
Wright Dose Ltd
Tel: 44 (0) 772 5636914
-Original Message-
From: [EMAIL PROTECTED] [mailto:[EMAIL PROTECTED]
On Behalf Of Nick Holford
Sent: 09 December 2008 20:52
To: nmusers@globomaxnm.com
Subject: Re: [NMusers] Simultaneous vs sequential for modeling parent
James, Mahesh,
The F=1 fallacy has caused me no end of stress over the years, and
next time I may have to contend with the (almost irrefutable) argument
but Nick Holford said it was true.
As I never said this was a fallacy I dont think you need be stressed by
it. Everytime you use a model
.
There are other assumptions that can be made depending on what you know.
Nick
James G Wright wrote:
Hi Nick,
You have written many things that are true, however I think we are
differing on a very essential point.
Nick Holford wrote
Everytime you use a model to describe oral PK data alone
in usernet archive but
could not solve the problem. I appreciate your help.
Regards,
Ayyappa Chaturvedula
GlaxoSmithKline
1500 Littleton Road,
Parsippany, NJ 07054
Ph:9738892200
--
Nick Holford, Dept Pharmacology Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag 92019
, UK. His research interest is in population and
physiologically-based pharmacokinetics. He is co-editor of the Journal
of Pharmacokinetics and Pharmacodynamics and executive editor of the
British Journal of Clinical Pharmacology.
Nick Holford is Associate Professor of Clinical Pharmacology
editor of the
British Journal of Clinical Pharmacology.
Nick Holford is Associate Professor of Clinical Pharmacology at the
University of Auckland, Auckland, New Zealand. He has been involved in
PKPD modelling for over 30 years. He has a particular interest in
describing disease progression
Antonio, TX 78229 USA
_peter.bon...@genzyme.com_ mailto:peter.bon...@genzyme.com
phone: 210-949-8662
fax: 210-949-8219
crackberry: 210-315-2713
alea jacta est - The die is cast.
Julius Caesar
--
Nick Holford, Dept Pharmacology Clinical Pharmacology
University of Auckland, 85 Park
-2713
alea jacta est - The die is cast.
Julius Caesar
--
Nick Holford, Dept Pharmacology Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand
n.holf...@auckland.ac.nz tel:+64(9)923-6730 fax:+64(9)373-7090
http://www.fmhs.auckland.ac.nz/sms
specific simulation/estimation cycles,
for some designs it stop even before 10th iterations.
Is there anyway nonmem could continue go on?
Or, does someone know alternative way to achieve the goal?
thanks
--
Nick Holford, Dept Pharmacology Clinical Pharmacology
University of Auckland, 85
of
Manchester, UK. His research interest is in population and
physiologically-based pharmacokinetics. He is co-editor of the Journal
of Pharmacokinetics and Pharmacodynamics and executive editor of the
British Journal of Clinical Pharmacology.
*Nick Holford* is Associate Professor of Clinical
to be the views of the sender's company. For further information about Actelion please see our website at http://www.actelion.com
--
Nick Holford, Dept Pharmacology Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand
n.holf...@auckland.ac.nz tel:+64
Sorry -- this sentence need a 'not' as follows:
This estimate is of course a shrinkage estimate which will typically be
biased towards the population CL but I have NOT realized that there is
also EBE bias from the choice of transformation used in parameter
estimation.
Nick Holford wrote
. My
question is, How to perform visual predictive check with mixture model?
I will be thankful for your suggestion and references.
Best regards
Satyendra Suryawanshi, PhD
University of Tennessee Health Science Center
--
Nick Holford, Dept Pharmacology Clinical
to correct for the Bayesian shrinkage
problem for obtaining MIXEST?
Nick
Nick Holford wrote:
Mats,
A VPC relies on simulation alone - there is no estimation step.
Presumably if the population estimate of the % of poor metabolizers is
5% then NONMEM will simulate 5% of the population as a poor
://www.actelion.com
--
Nick Holford, Dept Pharmacology Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand
n.holf...@auckland.ac.nz tel:+64(9)923-6730 fax:+64(9)373-7090
mobile: +33 64 271-6369 (Apr 6-Jul 17 2009)
http://www.fmhs.auckland.ac.nz
?
--
Nick Holford, Dept Pharmacology Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand
n.holf...@auckland.ac.nz tel:+64(9)923-6730 fax:+64(9)373-7090
mobile: +33 64 271-6369 (Apr 6-Jul 17 2009)
http://www.fmhs.auckland.ac.nz/sms/pharmacology/holford
selection
From: Nick Holford n.holf...@auckland.ac.nz
Date: Wed, April 15, 2009 12:17 pm
To: nmusers@globomaxnm.com
Ethan,
Do not pay any attention to whether or not the $COV step runs or
even if
the run is 'SUCCESSFUL' to conclude anything about your model. Your
the views and opinions of the employer.
--
--
Nick Holford, Dept Pharmacology Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand
n.holf...@auckland.ac.nz tel:+64(9)923-6730 fax
job listing and conferences) are archived
(eventually) online and are searchable
PK/PD Jobs can be found at
http://www.boomer.org/pkin/pkjob.html
--
Nick Holford, Dept Pharmacology Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand
n.holf
transmission in error, please reply to the
sender, so that
ICON plc can arrange for proper delivery, and then please delete the message.
Thank You,
ICON plc
South County Business Park
Leopardstown
Dublin 18
Ireland
Registered number: 145835
--
Nick Holford, Dept Pharmacology Clinical
are: IGNORE
52
Can someone tell me how to ignore more than one?
Thanks in advance.
--
Nick Holford, Dept Pharmacology Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand
n.holf...@auckland.ac.nz tel:+64(9)923-6730 fax:+64(9)373-7090
mobile
Pharmaceuticals Ltd / Gewerbestrasse 16 / CH-4123 Allschwil /
Switzerland
phone +41 61 565 6891 / fax +41 61 565 66 96
andreas.kra...@actelion.com / www.actelion.com
*Nick Holford n.holf...@auckland.ac.nz*
Sent by: owner-nmus...@globomaxnm.com
06/02/2009 11:05 AM
To
nmusers
includes
some minor bug fixes.
Please let me know if/when you discover bugs.
Nick
--
Nick Holford, Dept Pharmacology Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand
n.holf...@auckland.ac.nz tel:+64(9)923-6730 fax:+64(9)373-7090
mobile: +33 64 271
confirmed in writing.
--
Nick Holford, Dept Pharmacology Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand
n.holf...@auckland.ac.nz tel:+64(9)923-6730 fax:+64(9)373-7090
mobile: +33 64 271-6369 (Apr 6-Jul 17 2009)
http://www.fmhs.auckland.ac.nz
Nachricht-
Von: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com] Im
Auftrag von Nick Holford
Gesendet: Mittwoch, 8. Juli 2009 15:39
An: nmusers
Betreff: Re: [NMusers] Simulations with/without residual error
Andreas,
My suggestion:
If you want to compare your simulations
not with the estimated residual error but rather with a
residual error set to the imprecision of the measurement method?
Best regards, Andreas.
.
-Ursprüngliche Nachricht-
Von: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com] Im
Auftrag von Nick Holford
Gesendet: Mittwoch, 8. Juli 2009 15
and Simulation
Actelion Pharmaceuticals Ltd / Gewerbestrasse 16 / CH-4123 Allschwil /
Switzerland
andreas.kra...@actelion.com / www.actelion.com
*Nick Holford n.holf...@auckland.ac.nz*
Sent by: owner-nmus...@globomaxnm.com
07/09/2009 11:51 AM
To
nmusers nmusers@globomaxnm.com
to evaluate if the uncertainty distributions
might be close to being normal. The same effort can produce more robust
posterior distributions which can then be used directly.
Best wishes,
Nick
Holford NHG, Peace KE. Results and validation of a population
pharmacodynamic model for cognitive
[mailto:owner-
nmus...@globomaxnm.com] On Behalf Of Nick Holford
Sent: Saturday, 11 July 2009 6:31 a.m.
To: nmusers
Subject: Re: [NMusers] OMEGA off-diagonal elements parameterized as
correlations
Alison,
Thanks very much for taking the time to document the history of the
CORRELATION option. I hope
in NONMEM.
Steve
-Original Message-
From: A.J. Rossini [mailto:blindgl...@gmail.com]
Sent: Wednesday, 22 July 2009 5:31 p.m.
To: Stephen Duffull
Cc: Nick Holford; nmusers
Subject: Re: [NMusers] Modeling of two time-to-event outcomes
For 2 event-time responses, without regression, copula
...@otago.ac.nz
P: +64 3 479 5044
F: +64 3 479 7034
Design software: www.winpopt.com
--
Nick Holford, Professor Clinical Pharmacology
Dept Pharmacology Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New
Zealand
n.holf...@auckland.ac.nz tel:+64(9)923-6730
4714105
fax: +46 18 471 4003
Nick Holford wrote:
$SIM (20090709) ONLYSIM SUBPROBLEMS=100
; estimates of THETA and OMEGA from previous run
$THETA
1 ; POP_CL theta1
10 ; POP_V theta2
$OMEGA
0.5 ; PPV_CL eta1
0.5 ; PPV_V eta2
;variance-covariance matrix of the THETA estimates from previous run
$OMEGA
if anyone can provide me with a reference or point
me to where I can find this information, including the type of
equation used for extravascular, iv bolus and iv infusion models.
Thanks,
Sherwin
--
Nick Holford, Professor Clinical Pharmacology
Dept Pharmacology Clinical Pharmacology
University
: +46 18 471 4003
--
Nick Holford, Professor Clinical Pharmacology
Dept Pharmacology Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand
n.holf...@auckland.ac.nz tel:+64(9)923-6730 fax:+64(9)373-7090
mobile: +64 21 46 23 53
http
-Original Message-
From: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com] On
Behalf Of Nick Holford
Sent: Thursday, August 06, 2009 9:48 PM
To: nmusers
Subject: [NMusers] Re: count simulations
Mats,
Thanks for pointing out that R and 1-R are equivalent when R is a
uniform 0-1
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